Ambistryn-S 1gm Injection (Streptomycin): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or swelling in legs
- Ringing in the ears or hearing loss
- Severe dizziness or balance problems
- Numbness, tingling, or muscle weakness
- Difficulty breathing or swallowing
- Rash, itching, or swelling of face or throat
- Severe abdominal pain or blood in stool
If experiencing severe symptoms, call emergency services immediately.
What is ambistryn-s 1gm injection used for?
Ambistryn-S 1gm Injection contains streptomycin, an aminoglycoside antibiotic used to treat serious bacterial infections such as tuberculosis, plague, and tularemia. It is given intravenously by a healthcare professional and requires monitoring of kidney function and hearing.
- Generic Name: Streptomycin
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ambistryn-s 1gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा स्ट्रेप्टोमाइसिन नामक एंटीबायोटिक है, जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों जैसे तपेदिक (टीबी), प्लेग, टुलारेमिया और ब्रुसेलोसिस के इलाज के लिए किया जाता है। यह इंजेक्शन के रूप में नस के माध्यम से दी जाती है और इसे केवल डॉक्टर या स्वास्थ्यकर्मी द्वारा ही लगाया जाता है। यह दवा बैक्टीरिया को मारने में मदद करती है और संक्रमण को फैलने से रोकती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, सिरदर्द, चक्कर आना और इंजेक्शन लगाने की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में किडनी की समस्या, सुनने में कमी, संतुलन की समस्या और तंत्रिका क्षति हो सकती है। अगर आपको कान में घंटी बजना, सुनने में परेशानी, चक्कर आना या पेशाब कम आना जैसे लक्षण दिखें तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर की देखरेख में ही दी जानी चाहिए। इसे खुद से न लगाएं। अगर आपको किडनी की बीमारी, सुनने की समस्या, मांसपेशियों में कमजोरी या किसी दवा से एलर्जी है तो डॉक्टर को पहले बताएं। इलाज के दौरान किडनी की जांच और सुनने की जांच करवाते रहें। चक्कर आने पर वाहन न चलाएं। डॉक्टर के बताए अनुसार पूरा कोर्स पूरा करें।
💊 ambistryn-s 1gm injection Uses & Benefits
[{"condition":"Tuberculosis","description":"Used as a second-line injectable agent in combination with other antitubercular drugs for drug-resistant or complicated tuberculosis.","evidence":"Well-established"},{"condition":"Plague","description":"Effective against Yersinia pestis, the bacterium that causes plague, and is used in confirmed or suspected cases.","evidence":"Well-established"},{"condition":"Tularemia","description":"Used to treat tularemia caused by Francisella tularensis, especially in severe or systemic cases.","evidence":"Well-established"},{"condition":"Brucellosis","description":"Combined with other antibiotics such as doxycycline for treating brucellosis.","evidence":"Well-established"},{"condition":"Enterococcal endocarditis","description":"Used in combination with penicillin or ampicillin for enterococcal endocarditis when other options are not suitable.","evidence":"Established"},{"condition":"Gram-negative infections","description":"May be used for serious infections caused by susceptible gram-negative bacteria when other antibiotics are ineffective.","evidence":"Established"}]
Off-label uses: [{"condition":"Mycobacterium avium complex (MAC) infections","description":"Sometimes used off-label as part of a combination regimen for MAC infections in certain patients.","evidence":"Limited"},{"condition":"Whipple's disease","description":"Rarely used off-label for Whipple's disease caused by Tropheryma whipplei when standard treatments fail.","evidence":"Limited"}]
Primary treatment for: Tuberculosis (drug-resistant or complicated cases)
Also treats: Plague, Tularemia, Brucellosis, Enterococcal endocarditis, Serious gram-negative infections
📋 Drug Information
| Generic Name(s) | Streptomycin |
| Brand Name | Ambistryn-S 0.75gm Injection |
| Manufacturer | Abbott |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Aminoglycosides |
| Route of Administration | Intravenous (IV) infusion or injection, administered by a healthcare professional |
| Storage | Store at controlled room temperature (20°C to 25°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | The shelf life is typically 24 to 36 months from the date of manufacture, depending on the specific product. Check the expiration date on the vial before use. |
| WHO Guideline | The World Health Organization includes streptomycin as a second-line injectable agent for the treatment of drug-resistant tuberculosis in certain regimens. It is also recommended for plague and tularemia. Always follow national guidelines. |
| ICMR Guideline | The Indian Council of Medical Research includes streptomycin as a second-line antitubercular drug for drug-resistant tuberculosis. It is also recommended for plague and tularemia. Consult the latest ICMR guidelines for specific recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is an aminoglycoside antibiotic that binds irreversibly to the 30S ribosomal subunit of susceptible bacteria. This binding interferes with the initiation of protein synthesis and causes misreading of messenger RNA, leading to the production of faulty proteins. These abnormal proteins disrupt bacterial cell membrane integrity, ultimately causing bacterial cell death. The action is bactericidal, meaning it kills bacteria rather than just stopping their growth.
Mechanism Steps
💡 How to Take ambistryn-s 1gm injection
Strength: Ambistryn-S 1gm Injection: Each vial contains streptomycin 1 gram as a sterile powder for reconstitution.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, severity of infection, patient weight, kidney function, and other factors. For tuberculosis, it is often given as 15 mg/kg per day (maximum 1 gram) intramuscularly or intravenously, sometimes 5 days per week. For other infections, doses may range from 1 to 2 grams per day in divided doses. Always follow the prescribed regimen exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may have reduced kidney function and are at higher risk of toxicity. Doses should be adjusted based on kidney function. Close monitoring of kidney function and hearing is recommended. |
| Renal Impairment | Doses must be adjusted in patients with kidney impairment. The dose and/or dosing interval should be modified based on creatinine clearance. Close monitoring of kidney function is essential. |
| Hepatic Impairment | No specific dosage adjustment is required for liver impairment, as this medicine is not metabolized by the liver. However, monitor for any signs of toxicity. |
| Maximum Daily Dose | The maximum daily dose is typically 2 grams, but this must be determined by a qualified clinician based on the indication and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ambistryn-s 1gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Vecuronium | Major | |
| Vancomycin | Major | |
| Amphotericin B | Major | |
| Penicillin G | Moderate | |
| Indomethacin | Moderate | |
| Cyclosporine | Moderate | |
| Warfarin | Minor | |
| Oral antidiabetics | Minor |
🚨 Major Interactions
- Other aminoglycosides (e.g., gentamicin, amikacin)
- Loop diuretics (e.g., furosemide, ethacrynic acid)
- Neuromuscular blocking agents (e.g., succinylcholine, vecuronium)
- Vancomycin
- Amphotericin B
⚡ Moderate Interactions
- Penicillins (e.g., penicillin G, ampicillin)
- Cephalosporins
- Indomethacin
- Cyclosporine
🍷 Alcohol Interaction
Alcohol may increase the risk of kidney and liver problems. It is advisable to avoid alcohol while receiving this medicine, especially if you have underlying kidney or liver disease.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to streptomycin or other aminoglycosides","Pre-existing hearing loss or vestibular dysfunction","Severe kidney impairment","Myasthenia gravis (unless absolutely necessary and under close supervision)","Concurrent use with other nephrotoxic or ototoxic drugs (relative contraindication)"]
⚠️ Warnings & Precautions
["This medicine can cause serious kidney damage. Monitor kidney function closely.","This medicine can cause hearing loss, which may be irreversible. Report any ringing in the ears or hearing difficulty immediately.","This medicine can cause nerve damage, including numbness, tingling, or muscle weakness.","This medicine can cause neuromuscular blockade, which may lead to respiratory depression. Use with caution in patients with neuromuscular disorders.","This medicine should be used with caution in elderly patients due to reduced kidney function.","This medicine should be used with caution in patients with pre-existing kidney or hearing problems.","This medicine may cause allergic reactions, including severe anaphylaxis.","This medicine should not be used for viral infections.","This medicine should be used with caution in pregnancy and lactation.","This medicine should be administered only by healthcare professionals."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor.
💊 Overdose Management
Overdose of this medicine can cause severe kidney damage, hearing loss, and neuromuscular blockade. There is no specific antidote. Treatment is supportive and may include hemodialysis to remove the drug from the blood. If overdose is suspected, seek emergency medical attention immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional in a clinical setting. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered only by a healthcare professional in a clinical setting. Do not self-administer. Inform your doctor about any kidney disease, hearing problems, muscle weakness, or allergies before receiving this medicine. Your doctor will monitor your kidney function, hearing, and blood counts during treatment. Avoid other kidney-damaging or ear-damaging medicines unless specifically prescribed. Do not drive or operate heavy machinery if you feel dizzy or have vision changes. Complete the full course as prescribed, even if you feel better, to prevent resistance.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney damage and hearing loss due to age-related decline in kidney function. Doses should be adjusted based on kidney function, and monitoring should be more frequent.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm, including congenital deafness. If you are planning pregnancy, discuss with your doctor about alternative treatments. Use effective contraception during treatment if you are of childbearing potential.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent infections after surgery. It should be administered under medical supervision. Inform your surgeon if you are on this medicine before any surgery.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may increase the risk of bleeding or infection. Your dentist may recommend postponing non-urgent dental work until you complete treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy, weak, or have muscle weakness. Consult your doctor before starting any exercise program while on this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a clinical setting and may require frequent visits. You may experience dizziness or fatigue, which can affect your ability to drive or operate machinery. Plan your work schedule accordingly and avoid hazardous activities until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to treatment failure and antibiotic resistance. Your doctor will determine the appropriate duration of treatment based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of kidney damage and hearing loss. Regular monitoring of kidney function and hearing is essential. The risk of toxicity is higher with prolonged treatment, higher doses, and in patients with pre-existing kidney disease. When used appropriately and monitored closely, the benefits often outweigh the risks for serious infections.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection, other antibiotics such as gentamicin, amikacin, or beta-lactams may be used.
Evidence: Well-establishedRest, hydration, and symptomatic treatment can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, live vaccines should be avoided during treatment with antibiotics. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if expired
✈️ Traveling with This Medicine
If you are traveling while on this medicine, carry it in its original packaging with the prescription label. Carry a copy of your prescription and a letter from your doctor explaining the medical need. Since this medicine is given intravenously, you will need to arrange for administration at a healthcare facility at your destination. Store the vials at room temperature and protect from light. Check customs regulations for carrying injectable medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30-60 minutes after administration, but clinical improvement may take several days to weeks depending on the infection.
A: No, this medicine must be given by a healthcare professional in a clinical setting.
A: Watch for decreased urine output, ringing in the ears, hearing loss, dizziness, and muscle weakness. Report these immediately.
A: Pediatric dosing is not established from available information. Consult a pediatrician.
A: Avoid driving if you feel dizzy or have vision changes. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for ambistryn-s 1gm injection
View AllAlternative brands with exact same active ingredient:
-
merstrep 1gm injectionWockhardt Ltd ₹4.01 64.8% CHEAPER
-
streptomac 1gm injectionMacleods Pharmaceuticals Pvt Ltd ₹9.93 12.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Streptomycin can be taken orally.
Fact: Streptomycin is not absorbed orally and must be given by injection. - Myth: Streptomycin is safe for everyone.
Fact: Streptomycin can cause serious kidney and ear damage and is not suitable for everyone. - Myth: Streptomycin can cure viral infections.
Fact: Streptomycin is an antibiotic and is ineffective against viruses.
🔄 Alternative Options
Generic Alternatives
- Streptomycin 1gm Injection
Brand Alternatives
- Ambistryn-S 1gm Injection