Amat 5mg/10mg Tablet: Comprehensive Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe muscle pain, tenderness, or weakness, especially with dark urine.
- Yellowing of the skin or eyes, or severe abdominal pain.
- Swelling of the face, lips, throat, or tongue, or difficulty breathing.
- Fainting or severe dizziness.
- New or worsening chest pain.
- Unusual bleeding or bruising.
- Decreased urine output or swelling in the legs.
If experiencing severe symptoms, call emergency services immediately.
What is amat 5mg/10mg tablet used for?
This medicine is a combination of Amlodipine 5 mg and Atorvastatin 10 mg used to treat high blood pressure and high cholesterol. It is taken orally once daily as prescribed by your doctor.
- Generic Name: Amlodipine + Atorvastatin
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amat 5mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एम्लोडिपिन 5 मिलीग्राम और एटोरवास्टेटिन 10 मिलीग्राम का संयोजन है। इसका उपयोग उच्च रक्तचाप और उच्च कोलेस्ट्रॉल के इलाज के लिए किया जाता है। एम्लोडिपिन रक्त वाहिकाओं को आराम देकर रक्तचाप कम करता है, जबकि एटोरवास्टेटिन यकृत में कोलेस्ट्रॉल बनने को रोकता है। यह दवा हृदय रोग, दिल के दौरे और स्ट्रोक के जोखिम को कम करने में मदद करती है। इसे डॉक्टर के निर्देशानुसार प्रतिदिन एक बार मुँह से लिया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में टखनों या पैरों में सूजन, सिरदर्द, चक्कर आना, थकान, मतली, अपच और मांसपेशियों में दर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन तुरंत डॉक्टर से संपर्क करें यदि आपको गंभीर मांसपेशियों में दर्द या कमजोरी, गहरे रंग का पेशाब, आंखों या त्वचा का पीलापन, सांस लेने में कठिनाई, या चेहरे, होंठों या गले में सूजन हो।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे पानी के साथ पूरा निगलें। भोजन के साथ या बिना भोजन के ले सकते हैं, लेकिन भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। अंगूर का रस न पिएं क्योंकि इससे दवा का स्तर बढ़ सकता है। शराब का सेवन सीमित करें या बिल्कुल न करें। अपने डॉक्टर से नियमित रूप से रक्तचाप, कोलेस्ट्रॉल, यकृत और गुर्दे की जांच करवाएं। गर्भवती या स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें। दवा को कमरे के तापमान पर, नमी और सीधी धूप से दूर रखें।
💊 amat 5mg/10mg tablet Uses & Benefits
[{"condition":"Hypertension with dyslipidemia","description":"This medicine is used to lower high blood pressure and simultaneously reduce elevated LDL cholesterol and triglycerides in adults who require both treatments.","evidence":"Well-established"},{"condition":"Primary hypercholesterolemia","description":"Atorvastatin component lowers LDL cholesterol and total cholesterol in patients with high cholesterol not controlled by diet alone.","evidence":"Well-established"},{"condition":"Mixed dyslipidemia","description":"This medicine helps lower LDL cholesterol, total cholesterol, and triglycerides while modestly increasing HDL cholesterol.","evidence":"Well-established"},{"condition":"Cardiovascular risk reduction","description":"In patients with multiple risk factors, this combination may reduce the risk of heart attack, stroke, and revascularization procedures.","evidence":"Well-established"},{"condition":"Angina prophylaxis","description":"Amlodipine component is used to prevent angina attacks in patients with chronic stable angina or vasospastic angina.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Raynaud's phenomenon","description":"Amlodipine may be used off-label to reduce the frequency and severity of Raynaud's attacks.","evidence":"Limited"},{"condition":"Diabetic nephropathy","description":"Amlodipine may be used as part of blood pressure control in patients with diabetic kidney disease, though ACE inhibitors or ARBs are preferred.","evidence":"Limited"}]
Primary treatment for: Hypertension with dyslipidemia
Also treats: Hypercholesterolemia, Mixed dyslipidemia, Angina pectoris, Cardiovascular risk reduction
📋 Drug Information
| Generic Name(s) | Amlodipine + Atorvastatin |
| Brand Name | Amat 5mg/10mg tablet |
| Manufacturer | Abbott |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Calcium channel blocker + HMG-CoA reductase inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle cells. This causes relaxation of peripheral arterial smooth muscle, leading to reduced peripheral vascular resistance and lower blood pressure. Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate, a rate-limiting step in cholesterol biosynthesis. By inhibiting this enzyme, atorvastatin reduces cholesterol synthesis in the liver and increases the number of LDL receptors on hepatocytes, which enhances uptake and catabolism of LDL cholesterol from the blood. The combined effect is reduction of blood pressure and improvement of lipid profile.
Mechanism Steps
💡 How to Take amat 5mg/10mg tablet
Strength: Amlodipine 5 mg and Atorvastatin 10 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of Amlodipine 5 mg and Atorvastatin 10 mg taken orally once daily. The dose may be adjusted by your doctor based on your blood pressure and cholesterol levels. Some patients may require higher strengths or additional medicines. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. Do not change the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects of amlodipine. Start with a low dose and monitor blood pressure closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment of amlodipine is required for mild to moderate renal impairment. Atorvastatin does not require dose adjustment in renal impairment. However, use with caution in severe renal impairment. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine is contraindicated in patients with active liver disease or unexplained persistent elevations of liver enzymes. Use with caution in patients with a history of liver disease or heavy alcohol use. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended dose of amlodipine is 10 mg once daily. The maximum recommended dose of atorvastatin is 80 mg once daily. However, this fixed-dose combination is available in specific strengths, and the maximum daily dose should not exceed the prescribed strength. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amat 5mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Clarithromycin | Major | |
| Itraconazole | Major | |
| Ritonavir | Major | |
| Cyclosporine | Major | |
| Gemfibrozil | Major | |
| Warfarin | Moderate | |
| Digoxin | Moderate | |
| Simvastatin | Moderate | |
| Diltiazem | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, ritonavir)
- Grapefruit juice
- Cyclosporine
- Gemfibrozil
⚡ Moderate Interactions
- Warfarin
- Digoxin
- Simvastatin
- Diltiazem
🍷 Alcohol Interaction
Alcohol may increase the risk of liver damage from atorvastatin and can worsen blood pressure control. It is advisable to limit or avoid alcohol while taking this medicine. If you drink alcohol, talk to your doctor about safe limits.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to amlodipine, atorvastatin, or any component of the formulation","Active liver disease or unexplained persistent elevations of serum transaminases","Pregnancy","Breastfeeding","Women of childbearing potential not using effective contraception","Severe hypotension","Cardiogenic shock","Severe aortic stenosis"]
⚠️ Warnings & Precautions
["Monitor for muscle pain, tenderness, or weakness; report promptly.","Monitor liver enzymes before and during treatment.","Avoid grapefruit juice and strong CYP3A4 inhibitors.","Use caution in patients with renal impairment.","Use caution in elderly patients; monitor for hypotension and falls.","Do not stop abruptly without medical advice.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Alcohol may increase risk of liver problems.","Inform your doctor if you have diabetes; statins may increase blood sugar levels.","Report any unusual bleeding or bruising."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding. Both amlodipine and atorvastatin may pass into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose of this medicine may cause severe hypotension, dizziness, fainting, and muscle pain. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis is not expected to be effective for amlodipine or atorvastatin. Contact a poison control center for guidance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water. You can take it with or without food, but taking it with food may reduce stomach upset. Do not crush, chew, or break the tablet unless your doctor tells you to. Do not take more than the prescribed dose. Keep all your doctor appointments and get your blood pressure, cholesterol, liver enzymes, and kidney function checked regularly. Tell your doctor about all other medicines, supplements, and herbal products you take, because this medicine can interact with many substances. Avoid drinking grapefruit juice while taking this medicine, as it can increase the levels of atorvastatin in your body and raise the risk of side effects. Limit or avoid alcohol, as it can increase the risk of liver problems and may affect your blood pressure. Do not stop taking this medicine suddenly without talking to your doctor, because stopping blood pressure medicine abruptly can be dangerous. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before taking this medicine. Store this medicine at room temperature, away from moisture and direct sunlight, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of amlodipine and are at higher risk of dizziness and falls. Start with a low dose and monitor blood pressure regularly. Dose must be individualized by a qualified clinician.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and in women planning to become pregnant. If you are planning pregnancy, consult your doctor to switch to safer alternatives before conception. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery, especially if you are at risk of hypotension. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or increase bleeding risk. Your dentist may take precautions. Do not stop the medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is beneficial, but avoid sudden strenuous activity if you are not used to it. If you experience dizziness, chest pain, or shortness of breath during exercise, stop and consult your doctor. Stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities with minor adjustments.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects, your doctor may adjust the dose or switch to another medicine. Stopping suddenly can lead to rebound high blood pressure or cardiovascular events.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. Regular check-ups of blood pressure, lipid profile, liver enzymes, and kidney function are necessary. Rarely, long-term statin use may be associated with an increased risk of diabetes and muscle problems. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help control blood pressure and cholesterol.
Evidence: Well-establishedACE inhibitors, ARBs, beta-blockers, and other statins may be alternatives based on individual needs.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your healthcare provider about this medicine before receiving any vaccine. Continue routine vaccinations as recommended.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, continue taking your dose at the same time each day as close as possible. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Amlodipine starts lowering blood pressure within 24-48 hours, but full effect may take 1-2 weeks. Atorvastatin starts lowering cholesterol within 2 weeks, with maximum effect in 4-6 weeks.
A: Yes, you can take it at night, but it is best to take it at the same time each day as advised by your doctor.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop without consulting your doctor. High blood pressure and high cholesterol often have no symptoms, and stopping can lead to complications.
A: No, this medicine is not recommended during pregnancy. Consult your doctor for alternative treatments.
🤔 Common Patient Concerns
🔄 Substitutes for amat 5mg/10mg tablet
View AllAlternative brands with exact same active ingredient:
-
a2 5mg/10mg tabletZydus Cadila ₹32.12 19.7% CHEAPER
-
a2 5 mg/10 mg tabletZydus Cadila ₹37.52 6.2% CHEAPER
-
zivast-am tabletFDC Ltd ₹44.06 10.2% COSTLIER
-
lipikind am 5 mg/10 mg tabletMankind Pharma Ltd ₹44.58 11.5% COSTLIER
-
amlochol 5 mg/10 mg tabletAristo Pharmaceuticals Pvt Ltd ₹46.43 16.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure and cholesterol are normal.
Fact: High blood pressure and high cholesterol are chronic conditions. Stopping the medicine can cause them to rise again. Always consult your doctor before stopping. - Myth: This medicine damages the liver in everyone.
Fact: Liver problems are rare. Your doctor will monitor liver enzymes periodically. Report any symptoms like yellowing of eyes or skin. - Myth: Taking this medicine means I can eat whatever I want.
Fact: Diet and lifestyle changes are essential. This medicine works best when combined with a healthy diet and regular exercise. - Myth: This medicine causes memory loss.
Fact: Some patients report memory issues with statins, but this is uncommon and reversible. Discuss with your doctor if concerned.
🔄 Alternative Options
Generic Alternatives
- Amlodipine + Atorvastatin generic
Brand Alternatives
- Amat 5mg/10mg Tablet