Asnim-P Tablet: Nimesulide + Paracetamol for Pain and Fever
What is alvonim p 100mg/325mg tablet used for?
This medicine is a combination of Nimesulide 100 mg and Paracetamol 325 mg used for short-term relief of acute pain and fever in adults. It should be taken orally with food, typically two to three times a day, for no more than 5 to 7 days. It is not recommended for children under 12 years, during pregnancy, or in patients with severe liver or kidney disease.
- Generic Name: Nimesulide (100mg) + Paracetamol (325mg)
- Manufacturer: Alvonics Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alvonim p 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड 100 मिलीग्राम और पैरासिटामोल 325 मिलीग्राम का संयोजन है। इसका उपयोग वयस्कों में तीव्र दर्द और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह सूजन और दर्द को कम करने में मदद करती है। इसका उपयोग 5 से 7 दिनों से अधिक नहीं करना चाहिए।
साइड इफेक्ट्स: सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, यकृत की क्षति और गंभीर त्वचा प्रतिक्रियाएं शामिल हो सकती हैं।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। खाली पेट न लें। अल्कोहल का सेवन न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें। बच्चों को 12 वर्ष से कम उम्र में न दें।
💊 alvonim p 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute pain","description":"Short-term relief of mild to moderate acute pain, such as musculoskeletal pain, dental pain, or post-operative pain."},{"condition":"Fever","description":"Reduction of elevated body temperature in adults."},{"condition":"Inflammatory conditions","description":"Short-term management of pain and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis."}]
Off-label uses: []
Primary treatment for: Acute pain and fever
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Dental pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Nimesulide (100mg) + Paracetamol (325mg) |
| Brand Name | alvonim p 100mg/325mg tablet |
| Manufacturer | Alvonics Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits cyclooxygenase-2 (COX-2) and also has additional effects on neutrophil function and cytokine production, leading to reduced prostaglandin synthesis and decreased inflammation and pain. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and modulating pain perception, and it also affects the hypothalamic heat-regulating center to reduce fever. Together, they provide analgesic, anti-inflammatory, and antipyretic effects.
Mechanism Steps
💡 How to Take alvonim p 100mg/325mg tablet
Strength: 100 mg + 325 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times a day, as prescribed by your doctor. The dose should not exceed the maximum daily limit. The duration of treatment should be as short as possible, typically not exceeding 5 to 7 days. |
| Pediatric Dosage | This medicine is not recommended for children below 12 years of age. For children above 12 years, the dose must be determined by a qualified clinician based on indication, age, weight, and renal/hepatic function. |
| Elderly Dosage | Elderly patients may be more susceptible to the side effects of this medicine, especially gastrointestinal bleeding and renal impairment. Use with caution and at the lowest effective dose for the shortest duration. Dose must be determined by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. This medicine is contraindicated in severe renal impairment (creatinine clearance <30 mL/min). Dose must be determined by a qualified clinician based on renal function. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. This medicine is contraindicated in severe hepatic impairment. Dose must be determined by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum daily dose of this medicine should not exceed 3 tablets in 24 hours. Do not exceed the recommended dose or duration. |
Dosage Timeline
⚠️ Side Effects of alvonim p 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Minor | ||
| Minor | ||
| Minor | ||
| Minor | ||
| Minor | ||
| Minor | ||
| Minor | ||
| Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs (e.g., aspirin, ibuprofen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors and angiotensin receptor blockers
- Diuretics
- Antihypertensives
- Alcohol
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity, particularly due to the Paracetamol component.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Nimesulide, Paracetamol, or any component of the formulation.","History of gastrointestinal bleeding or perforation related to NSAID use.","Active or history of peptic ulcer or recurrent gastrointestinal bleeding.","Severe liver impairment or active liver disease.","Severe kidney impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
[{"warning":"Gastrointestinal bleeding","reason":"Nimesulide can cause serious gastrointestinal bleeding, ulceration, and perforation.","action":"Use with caution in patients with a history of gastrointestinal disease. Avoid alcohol. Seek immediate medical attention if you notice black stools or vomit blood."},{"warning":"Hepatotoxicity","reason":"Paracetamol overdose can cause severe liver damage. Nimesulide can also cause liver injury.","action":"Do not exceed the recommended dose or duration. Avoid alcohol. Monitor liver function if prolonged use."},{"warning":"Nephrotoxicity","reason":"Nimesulide can impair kidney function, especially in dehydrated patients or those with pre-existing renal disease.","action":"Use with caution. Maintain adequate hydration. Monitor renal function."},{"warning":"Cardiovascular risk","reason":"Nimesulide may increase the risk of cardiovascular events.","action":"Use with caution in patients with cardiovascular disease. Avoid long-term use."},{"warning":"Severe skin reactions","reason":"Nimesulide and Paracetamol can cause rare but serious skin reactions.","action":"Stop the medicine and seek immediate medical attention if you develop a rash, blisters, or peeling skin."},{"warning":"Use in children","reason":"Safety and efficacy in children below 12 years are not established.","action":"Do not use in children below 12 years."}]
🤱 Lactation Safety
Nimesulide is not recommended during breastfeeding as it may pass into breast milk and cause harm to the infant. Paracetamol is considered safe during breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to Paracetamol and gastrointestinal bleeding, kidney failure, and other serious effects due to Nimesulide. Seek immediate medical attention. Treatment includes supportive care, activated charcoal if within 1-2 hours of ingestion, and administration of N-acetylcysteine for Paracetamol toxicity. Monitor liver and kidney function, and manage symptoms accordingly.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid taking it on an empty stomach to reduce gastrointestinal irritation. Do not consume alcohol while taking this medicine. Do not use this medicine if you have a history of stomach ulcers, bleeding disorders, severe liver or kidney disease, or if you are allergic to Nimesulide or Paracetamol. Do not take other products containing Paracetamol while on this medicine to avoid overdose. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children.
🔄 Substitutes for alvonim p 100mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
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jumolid plus 100 mg/325 mg tabletPsychotropics India Ltd ₹3.25 93.1% CHEAPER
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junocip 100 mg/325 mg tabletPsychotropics India Ltd ₹3.52 92.5% CHEAPER
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sunocet 100mg/325mg tabletShreya Life Sciences Pvt Ltd ₹3.52 92.5% CHEAPER
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nimelide plus 100 mg/325 mg tabletCadila Pharmaceuticals Ltd ₹5.50 88.3% CHEAPER
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nimotas p 100mg/325mg tabletIntas Pharmaceuticals Ltd ₹5.69 87.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Asnim-P Tablet is safe for long-term use.
Fact: This medicine is intended for short-term use only, typically not exceeding 5 to 7 days, due to risks of gastrointestinal, liver, and kidney toxicity. - Myth: Asnim-P Tablet can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce the risk of stomach upset and gastrointestinal bleeding. - Myth: Asnim-P Tablet is safe for children.
Fact: This medicine is not recommended for children below 12 years of age. - Myth: Asnim-P Tablet can be taken with alcohol.
Fact: Alcohol should be avoided while taking this medicine as it increases the risk of liver damage and gastrointestinal bleeding.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol