altonil ls 5 tablet - Melatonin (5mg) + Clonazepam (0.25mg) medicine

Altonil LS 5 Tablet - Uses, Price, Side Effects

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🏭 Alteus Biogenics Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is altonil ls 5 tablet used for?

Altonil LS 5 Tablet is a combination medicine used to treat insomnia. It contains Melatonin (5mg), a hormone that regulates sleep-wake cycles, and Clonazepam (0.25mg), a benzodiazepine that reduces anxiety and promotes sleep. Together, they help you fall asleep faster and stay asleep longer. It is typically taken at night before bedtime.

  • Generic Name: Melatonin + Clonazepam
  • Manufacturer: Alteus Biogenics Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
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💊 altonil ls 5 tablet Uses & Benefits

Insomnia, sleep disorders, anxiety, seizure disorders (clonazepam component)

Off-label uses: Jet lag, circadian rhythm disorders, REM sleep behavior disorder

📋 Drug Information

Generic Name(s)Melatonin + Clonazepam
Brand NameAltonil Plus 5 Tablet
ManufacturerAlteus Biogenics Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassHypnotic and Sedative
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMelatonin: Rapidly absorbed; Clonazepam: Well absorbed orally
DistributionMelatonin: Widely distributed; Clonazepam: High lipophilicity, crosses blood-brain barrier
Protein BindingMelatonin: ~60%; Clonazepam: ~85%
MetabolismMelatonin: Hepatic via CYP1A2; Clonazepam: Hepatic via CYP3A4
Half-LifeMelatonin: 20-50 min; Clonazepam: 20-40 hours
ExcretionMelatonin: Renal; Clonazepam: Renal (<2% unchanged)
BioavailabilityMelatonin: ~15%; Clonazepam: ~90%
Onset of ActionMelatonin: 30-60 min; Clonazepam: 20-60 min
Peak Plasma TimeMelatonin: 1 hour; Clonazepam: 1-4 hours
Duration of ActionMelatonin: 4-8 hours; Clonazepam: 6-12 hours

How It Works

Melatonin: Agonist at melatonin receptors MT1 and MT2; Clonazepam: Enhances GABA-A receptor activity by binding to benzodiazepine site

Mechanism Steps

1Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, promoting sleep onset and circadian rhythm regulation.
2Clonazepam binds to the benzodiazepine site on GABA-A receptors, enhancing GABA's inhibitory effect, leading to increased chloride ion influx and neuronal hyperpolarization.
3The combined action results in sedation, anxiolysis, and muscle relaxation, facilitating sleep maintenance.

💡 How to Take altonil ls 5 tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ✅

⚠️ Side Effects of altonil ls 5 tablet

✅ Common Side Effects

Drowsiness
Dizziness
Headache
Fatigue
Ataxia
Nausea

🚨 Serious Side Effects

Respiratory depression
Paradoxical reactions
Dependence
Withdrawal seizures
Suicidal thoughts

⚠️ Rare Side Effects

Blood dyscrasias
Hepatic dysfunction
Anaphylaxis
Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Alcohol Major Increased sedation and risk of respiratory depression
CNS Depressants Major Additive sedative effects
Fluvoxamine Moderate Increased melatonin levels

🚨 Major Interactions

  • CNS depressants
  • Alcohol
  • Opioids
  • Sodium oxybate

⚡ Moderate Interactions

  • CYP3A4 inhibitors
  • CYP1A2 inhibitors
  • Fluvoxamine
  • Cimetidine

🍷 Alcohol Interaction

Additive CNS depression; avoid concurrent use

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, severe respiratory insufficiency, sleep apnea, myasthenia gravis, narrow-angle glaucoma, severe hepatic impairment

🤱 Lactation Safety

Not recommended; clonazepam excreted in breast milk

💊 Overdose Management

Supportive care, flumazenil for clonazepam overdose (caution in mixed overdoses), activated charcoal if recent ingestion

⏰ Missed Dose

Skip missed dose if near next dose; do not double dose

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