altirab-d 10mg/20mg tablet - Domperidone (10mg) + Rabeprazole (20mg) medicine

Alsar D 10mg/20mg Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Ultra Drugs Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Irregular heartbeat or palpitations
  • Severe dizziness or fainting
  • Muscle stiffness, tremors, or difficulty in movement
  • Breast enlargement or milky discharge
  • Signs of allergic reaction such as rash, swelling of face/lips/throat, or difficulty breathing
  • Blood in vomit or black, tarry stools
  • Severe abdominal pain

If experiencing severe symptoms, call emergency services immediately.

What is altirab-d 10mg/20mg tablet used for?

This medicine is a combination of Domperidone and Rabeprazole used to treat acid reflux, heartburn, and nausea. It works by reducing stomach acid and improving stomach emptying. It is usually taken once daily before breakfast.

  • Generic Name: Domperidone + Rabeprazole
  • Manufacturer: Ultra Drugs Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 altirab-d 10mg/20mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और रेबेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, सीने में जलन, अपच और मतली के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने की प्रक्रिया को तेज करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, दस्त, पेट दर्द और मतली शामिल हैं। कुछ लोगों को नींद या चक्कर आ सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको दिल की धड़कन में अनियमितता, स्तन में दर्द या मांसपेशियों में अकड़न महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे खाली पेट, नाश्ते से कम से कम 30 मिनट पहले लेना सबसे अच्छा है। इस दवा के साथ शराब न लें। यदि आपको दिल, लीवर या किडनी की कोई समस्या है, तो डॉक्टर को बताएं।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 altirab-d 10mg/20mg tablet Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces acid reflux and heartburn by inhibiting gastric acid secretion and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps relieve symptoms like bloating, early satiety, and upper abdominal discomfort.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with delayed gastric emptying","description":"Domperidone component enhances gastric motility and reduces nausea.","evidence":"Moderate"},{"condition":"Gastroparesis","description":"May improve symptoms of delayed stomach emptying, especially in diabetic gastroparesis.","evidence":"Limited"}]

Off-label uses: [{"condition":"Prevention of NSAID-induced ulcers","description":"Rabeprazole component may be used off-label to protect the stomach in patients on chronic NSAIDs.","evidence":"Limited"},{"condition":"Helicobacter pylori eradication","description":"Rabeprazole is sometimes included in combination regimens, but this fixed-dose product is not standard for this indication.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD)

Also treats: Functional dyspepsia, Gastroparesis, Nausea and vomiting

📋 Drug Information

Generic Name(s)Domperidone + Rabeprazole
Brand NameAcera-D Capsule SR
ManufacturerUltra Drugs Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine on an empty stomach, at least 30 minutes before breakfast, for best results.
2
Do not crush or chew the tablet; swallow it whole with water.
3
Avoid alcohol while taking this medicine as it can increase drowsiness and stomach irritation.
4
If you are on blood thinners like warfarin, inform your doctor as this medicine may interact.
5
Do not take this medicine for longer than prescribed without consulting your doctor.
6
Report any irregular heartbeat, dizziness, or muscle stiffness immediately.
7
Maintain a healthy diet and avoid spicy, fatty foods to reduce acid reflux symptoms.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heartburn
This medicine is commonly prescribed for this.
Likely Use
✅
Acid regurgitation
This medicine helps reduce acid reflux.
Likely Use
✅
Nausea
Domperidone component helps relieve nausea.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Headache
This medicine is not indicated for headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 30 to 60 minutes. Rabeprazole is also rapidly absorbed, with peak plasma levels reached in about 2 to 5 hours. Food may delay the absorption of rabeprazole, so it is recommended to take this medicine before meals.
DistributionDomperidone is widely distributed in the body but does not readily cross the blood-brain barrier. Rabeprazole is highly protein-bound and distributes extensively into tissues, particularly the gastric parietal cells.
Protein BindingDomperidone is approximately 91-93% bound to plasma proteins. Rabeprazole is about 96% bound to plasma proteins.
MetabolismDomperidone undergoes extensive first-pass metabolism in the liver via CYP3A4 and CYP1A2 enzymes. Rabeprazole is metabolized in the liver primarily by CYP2C19 and CYP3A4 enzymes.
Half-LifeThe elimination half-life of domperidone is approximately 7 to 9 hours. Rabeprazole has a terminal half-life of about 1 to 2 hours.
ExcretionDomperidone is excreted mainly in the feces (about 66%) and urine (about 33%). Rabeprazole is excreted primarily as metabolites in the urine (about 90%) and feces (about 10%).
BioavailabilityThe oral bioavailability of domperidone is about 13-17% due to first-pass metabolism. Rabeprazole has a bioavailability of approximately 52%.
Onset of ActionDomperidone's prokinetic effects begin within 30 to 60 minutes after oral administration. Rabeprazole's acid-suppressing effect starts within 1 hour, with maximum effect achieved after 2 to 4 hours.
Peak Plasma TimeDomperidone: 0.5 to 1 hour; Rabeprazole: 2 to 5 hours.
Duration of ActionDomperidone's effect lasts about 6 to 8 hours. Rabeprazole's acid suppression lasts up to 24 hours, allowing once-daily dosing.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract, leading to enhanced gastric motility and reduced nausea. Rabeprazole is a proton pump inhibitor that irreversibly inhibits the H+/K+ ATPase enzyme in gastric parietal cells, thereby suppressing both basal and stimulated gastric acid secretion.

Mechanism Steps

1
Domperidone blocks dopamine D2 receptors: Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract, which reduces nausea and enhances gastric motility.
2
Enhanced gastric emptying: By blocking D2 receptors, domperidone increases the tone of the lower esophageal sphincter and promotes coordinated contractions of the stomach and duodenum, leading to faster gastric emptying.
3
Rabeprazole inhibits proton pumps: Rabeprazole accumulates in the acidic environment of gastric parietal cells and irreversibly binds to the H+/K+ ATPase enzyme, blocking the final step of acid secretion.
4
Reduced gastric acid secretion: The inhibition of proton pumps leads to a significant decrease in both basal and stimulated gastric acid production, alleviating symptoms of acid reflux and promoting mucosal healing.

💡 How to Take altirab-d 10mg/20mg tablet

Strength: Tablet containing Domperidone 10 mg and Rabeprazole 20 mg.

1Take the tablet at the same time each day, preferably in the morning before food.
2Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
3If you are also taking antacids, take them at least 2 hours apart from this medicine.
4Follow your doctor's instructions regarding diet and other medications.
5Do not stop taking this medicine abruptly without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally once daily, preferably before breakfast. However, the dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, and renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially cardiac arrhythmias and extrapyramidal symptoms. Use with caution and lower doses may be considered as per clinician's judgment.
Renal ImpairmentIn patients with severe renal impairment (creatinine clearance <30 mL/min), the dose may need to be reduced or the medicine avoided. Consult a doctor for dose adjustment.
Hepatic ImpairmentIn patients with mild to moderate hepatic impairment, no dose adjustment is usually needed. However, in severe hepatic impairment, this medicine is contraindicated. Consult a doctor.
Maximum Daily DoseThe maximum recommended daily dose is one tablet (Domperidone 10 mg + Rabeprazole 20 mg) per day. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Food may delay the absorption of rabeprazole, reducing its efficacy.
Grapefruit juice
Avoid
May increase domperidone levels and risk of side effects.
High-fat meals
Avoid taking together
May reduce the effectiveness of the medicine.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of altirab-d 10mg/20mg tablet

✅ Common Side Effects

Dry mouth (Common (5-10%))
Sip water frequently and maintain good oral hygiene. Consult doctor if persistent.
Headache (Common (5-10%))
Usually resolves on its own. Rest and hydration may help. Consult doctor if severe.
Diarrhea (Common (5-10%))
Stay hydrated. Avoid fatty or spicy foods. Consult doctor if it persists beyond 2 days.
Abdominal pain (Common (5-10%))
Take with food if not contraindicated. Consult doctor if pain is severe or persistent.
Nausea (Common (5-10%))
Take the medicine exactly as prescribed. Avoid heavy meals. Consult doctor if nausea worsens.

🚨 Serious Side Effects

QT prolongation and ventricular arrhythmias (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, dizziness, or fainting.
Extrapyramidal symptoms (Rare (<0.1%))
Report muscle stiffness, tremors, or difficulty in movement to your doctor immediately.
Hyperprolactinemia (Uncommon (0.1-1%))
Consult doctor if you notice breast enlargement, tenderness, or milky discharge.
Severe allergic reactions (Rare (<0.1%))
Seek emergency help if you develop rash, swelling of face/lips/throat, or difficulty breathing.

⚠️ Rare Side Effects

Tardive dyskinesia
Report involuntary movements to your doctor immediately.
Neuroleptic malignant syndrome
Seek emergency care for high fever, muscle rigidity, and altered mental status.
Agranulocytosis
Report sudden fever, sore throat, or mouth ulcers to your doctor promptly.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clarithromycin Major
Amiodarone Major
Haloperidol Major
Warfarin Moderate
Methotrexate Moderate
Digoxin Moderate
Atazanavir Moderate
Antacids Minor
Sucralfate Minor

🚨 Major Interactions

  • Ketoconazole
  • Clarithromycin
  • Amiodarone
  • Haloperidol

⚡ Moderate Interactions

  • Warfarin
  • Methotrexate
  • Digoxin
  • Atazanavir

🍷 Alcohol Interaction

Alcohol may increase the risk of drowsiness, dizziness, and stomach irritation when taken with this medicine. It is advisable to avoid alcohol while on this medication.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to domperidone, rabeprazole, or any component of the formulation","Prolactin-releasing pituitary tumor (prolactinoma)","Severe hepatic impairment","Known QT prolongation or family history of long QT syndrome","Concomitant use with QT-prolonging drugs or potent CYP3A4 inhibitors","Gastrointestinal obstruction, perforation, or bleeding","Severe renal impairment (creatinine clearance

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease or risk factors for QT prolongation.","Avoid in patients with electrolyte disturbances such as hypokalemia or hypomagnesemia.","May cause drowsiness; avoid driving or operating machinery until effects are known.","Use with caution in elderly patients due to increased risk of side effects.","Do not use for prolonged periods without medical supervision.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Rabeprazole may increase the risk of bone fractures with long-term use.","May mask symptoms of gastric malignancy; rule out malignancy before starting therapy."]

🤱 Lactation Safety

Domperidone is excreted in breast milk and may cause side effects in the infant. Rabeprazole is also excreted in breast milk. Consult your doctor before breastfeeding while on this medicine.

💊 Overdose Management

Overdose may cause severe drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1 hour of ingestion. Monitor ECG and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with water. It is best taken on an empty stomach, at least 30 minutes before a meal, to maximize the effect of Rabeprazole. Avoid alcohol while taking this medicine as it may worsen stomach irritation and increase drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have a history of heart rhythm problems, liver disease, or kidney disease. Do not share this medicine with others, even if they have similar symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of cardiac arrhythmias, extrapyramidal symptoms, and drug interactions. Use with caution and monitor closely. Dose adjustment may be necessary.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

🏥 Post-Surgery Considerations

After surgery, use this medicine only if prescribed by your surgeon. It may affect gastric motility and acid secretion, which could impact post-operative recovery. Inform your surgeon about all medications you are taking.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with certain medications used during dental procedures. No specific precautions are established, but it is always good to disclose your medication history.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce pressure on the stomach.
🥗
Avoid lying down immediately after meals; wait at least 2-3 hours.
😴
Eat smaller, more frequent meals instead of large ones.
💧
Avoid spicy, fatty, and acidic foods that can trigger reflux.
🧘
Elevate the head of your bed while sleeping to prevent night-time reflux.
🌞
Quit smoking and limit alcohol consumption.

🏋️ Exercise Considerations

Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness or drowsiness. Light to moderate exercise is generally safe, but listen to your body and stay hydrated.

🥗 Diet Recommendations

Include fiber-rich foods like fruits and vegetables.
Avoid caffeine, chocolate, and mint, which can relax the lower esophageal sphincter.
Eat lean proteins and whole grains.
Stay well hydrated with water.
Limit carbonated drinks and citrus juices.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually taken once daily, so it should not significantly interfere with your daily routine.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Abrupt discontinuation may lead to rebound acid hypersecretion.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of bone fractures, vitamin B12 deficiency, and hyperprolactinemia. Regular monitoring of symptoms and periodic blood tests may be required. Do not use for prolonged periods without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Dietary changes, weight loss, and elevating the head of the bed can help manage GERD symptoms.

Evidence: Well-established
Other proton pump inhibitors

Pantoprazole, omeprazole, or esomeprazole may be used as alternatives.

Evidence: Well-established
H2 receptor blockers

Ranitidine or famotidine may be used for milder symptoms.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. However, if you are scheduled for any vaccination, inform your healthcare provider about this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue taking your dose at the same time each day as close as possible. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic acid reflux and nausea
He was prescribed this medicine once daily before breakfast. After two weeks, his heartburn and nausea significantly reduced. He also changed his diet, avoiding late-night meals and spicy foods. He reported mild dry mouth initially, which resolved on its own.
💡 Lesson: Taking the medicine as prescribed along with lifestyle changes leads to better symptom control.
👤 A 60-year-old woman with diabetic gastroparesis
She experienced early satiety, bloating, and nausea. Her doctor prescribed this medicine. She noticed improvement in her symptoms within a week. She was advised to monitor her blood sugar levels regularly and to report any palpitations.
💡 Lesson: This medicine can help with gastroparesis symptoms, but regular monitoring is essential, especially in elderly patients.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 30 to 60 minutes, but noticeable relief from symptoms may take a few days of regular use.

Q: Can I take this medicine with other medications?

A: It can interact with several drugs, so always inform your doctor about all medicines you are taking.

Q: Is it safe to take during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. It should be used only if clearly needed.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for altirab-d 10mg/20mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Alsar D is a painkiller.
    Fact: Alsar D is not a painkiller; it is a combination of a prokinetic and an acid suppressant used for acidity and nausea.
  • Myth: You can stop Alsar D as soon as you feel better.
    Fact: You should complete the prescribed course and consult your doctor before stopping, as abrupt discontinuation may cause rebound acidity.
  • Myth: Alsar D can be taken with alcohol.
    Fact: Alcohol may increase side effects like drowsiness and stomach irritation; it is best avoided.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Rabeprazole generic tablets

Brand Alternatives

  • Not established from the available information.

📊 Comparison with Similar Medicines

[{"medicine":"Domperidone + Rabeprazole","composition":"Domperidone 10mg + Rabeprazole 20mg","onset":"30-60 minutes","duration":"Up to 24 hours","notes":"This medicine"},{"medicine":"Domperidone + Pantoprazole","composition":"Domperidone 10mg + Pantoprazole 40mg","onset":"1 hour","duration":"Up to 24 hours","notes":"Alternative PPI combination"},{"medicine":"Domperidone + Omeprazole","composition":"Domperidone 10mg + Omeprazole 20mg","onset":"1 hour","duration":"Up to 24 hours","notes":"Alternative PPI combination"}]

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