alevo 250 tablet (Levofloxacin 250 mg): Complete Medicine Guide

[{"condition":"Acute bacterial sinusitis","description":"Used to treat bacterial infection of the sinuses when symptoms are severe, persistent, or worsening, and when other appropriate antibiotics are not suitable.","evidence":"Well-established"},{"condition":"Acute exacerbation of chronic bronchitis","description":"Prescribed for flare-ups of chronic bronchitis caused by susceptible bacteria, particularly in patients with underlying lung disease.","evidence":"Well-established"},{"condition":"Community-acquired pneumonia","description":"Used in selected patients with mild to moderate community-acquired pneumonia caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Complicated urinary tract infection and pyelonephritis","description":"Effective against many of the bacteria that cause kidney and upper urinary tract infections, including some resistant strains.","evidence":"Well-established"},{"condition":"Chronic bacterial prostatitis","description":"Prescribed for long-course treatment of bacterial prostatitis because it penetrates prostate tissue well.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for uncomplicated skin infections caused by susceptible bacteria when other options are unsuitable.","evidence":"Well-established"},{"condition":"Drug-resistant tuberculosis (as part of combination therapy)","description":"Included in some multi-drug regimens for drug-resistant tuberculosis under specialist supervision.","evidence":"Established in specialist settings"}]

Off-label uses: [{"condition":"Traveler's diarrhea","description":"Sometimes used for severe or persistent traveler's diarrhea caused by susceptible bacteria, though other agents are usually preferred.","evidence":"Limited"},{"condition":"Diverticulitis (mild, outpatient)","description":"Occasionally used as part of an outpatient regimen for uncomplicated diverticulitis in selected patients.","evidence":"Limited"}]

Primary treatment for: Bacterial infections caused by susceptible organisms

Also treats: Acute bacterial sinusitis, Acute exacerbation of chronic bronchitis, Community-acquired pneumonia, Complicated urinary tract infection, Pyelonephritis, Chronic bacterial prostatitis, Skin and soft tissue infections, Drug-resistant tuberculosis (specialist use)

Generic Name(s)	Levofloxacin
Brand Name	Alevo 500 Tablet
Manufacturer	Smilax Pharmaceuticals
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	OPHTHAL
Action Class	Quinolones/ Fluroquinolones
Route of Administration	Oral
Storage	Store this medicine at room temperature, between 15°C and 30°C, in its original blister pack or container. Keep it away from direct sunlight, moisture, and heat. Do not store it in the bathroom or near the kitchen stove. Keep it out of the reach of children and pets.
Shelf Life	The shelf life is typically 24 to 36 months from the date of manufacture when stored as directed. Always check the expiry date printed on the pack and do not use the medicine after that date.
WHO Guideline	The World Health Organization includes fluoroquinolones such as levofloxacin in its essential medicines list and in some treatment guidelines for specific infections, including drug-resistant tuberculosis. However, because of safety concerns and the need to preserve these antibiotics for when they are truly needed, the WHO and other public health bodies recommend using them only when a bacterial infection is confirmed or strongly suspected and when safer alternatives are not suitable. Always follow the advice of your local clinician and national treatment guidelines.
ICMR Guideline	The Indian Council of Medical Research has highlighted the importance of using antibiotics such as levofloxacin judiciously because of rising antimicrobial resistance in India. The ICMR treatment guidelines recommend using this medicine only for confirmed or strongly suspected bacterial infections, choosing the right dose and duration, and avoiding unnecessary use for viral illnesses. Clinicians are encouraged to follow local susceptibility data and to reserve fluoroquinolones for situations where they are clearly indicated.

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

Drug	Severity	Effect
Warfarin	Major
Amiodarone	Major
Tizanidine	Major
Insulin	Major
Ibuprofen	Major
Antacids	Moderate
Iron supplements	Moderate
Theophylline	Moderate
Prednisolone	Moderate
Methotrexate	Moderate

🚫 Contraindications

["Known allergy or hypersensitivity to levofloxacin or any other fluoroquinolone antibiotic","History of tendon disorders such as tendonitis or tendon rupture linked to fluoroquinolone use","Myasthenia gravis, because fluoroquinolones can worsen muscle weakness","Pregnancy, unless a specialist decides the benefit clearly outweighs the risk","Breastfeeding, unless the clinician advises otherwise after weighing the risks and benefits","Children and adolescents in most situations, because of concerns about effects on growing joints and cartilage","Use together with tizanidine"]

⚠️ Warnings & Precautions

["Fluoroquinolones, including this medicine, can cause disabling and potentially permanent side effects involving tendons, muscles, joints, nerves, and the central nervous system. These can occur together and may appear hours to weeks after starting treatment.","Stop the medicine and contact your clinician immediately if you develop tendon pain, swelling, or difficulty moving a joint, especially in the ankle, heel, or shoulder.","Report new numbness, tingling, burning, weakness, or changes in sensation in the hands or feet, as these may be signs of nerve damage.","This medicine can cause dizziness and confusion. Avoid driving or operating heavy machinery until you know how it affects you.","Avoid exposure to strong sunlight and tanning beds, because this medicine can make your skin more sensitive to sunlight and cause a rash.","Tell your clinician if you have diabetes, because this medicine can cause serious changes in blood sugar levels.","Tell your clinician if you have heart rhythm problems or take medicines that affect heart rhythm, because this medicine can prolong the QT interval.","Do not take antacids, sucralfate, or supplements containing iron, zinc, magnesium, or calcium within two hours of this medicine.","Complete the full course as prescribed, even if you feel better after a few days, to reduce the risk of the infection returning and of antibiotic resistance.","This medicine should not be used for viral infections such as the common cold or flu, because it will not help and may cause unnecessary side effects."]

🤱 Lactation Safety

This medicine passes into breast milk in small amounts. Because of potential effects on the infant's joints and gut bacteria, breastfeeding is usually avoided during treatment, or breastfeeding may be paused and expressed milk discarded for the duration of therapy. A clinician should be consulted to decide the safest approach for both mother and baby.

Additional Safety Advice

If you are trying to conceive, discuss this medicine with your clinician before starting it. Fluoroquinolones are generally avoided during pregnancy unless there is no safer effective alternative. If you become pregnant while taking this medicine, contact your clinician promptly so that your treatment can be reviewed and, if necessary, changed to a safer option.

If you are scheduled for surgery, tell your surgeon and anaesthetist that you are taking this medicine. This medicine can affect heart rhythm and blood sugar, which may be relevant during anaesthesia. In some cases, your clinician may advise stopping the medicine before surgery or switching to another antibiotic. Do not stop the medicine on your own without medical advice.

Tell your dentist that you are taking this medicine before any dental procedure. This medicine can interact with some medicines used during dental treatment, and it may affect blood sugar or heart rhythm. If you need a dental procedure while on this medicine, your dentist may coordinate with your clinician to ensure it is safe to proceed.

While taking this medicine, avoid strenuous or high-impact exercise, especially if you feel dizzy, tired, or have joint or tendon discomfort. Stop exercising and seek medical advice if you develop pain, swelling, or stiffness in a tendon or joint. Gentle walking and light activity are usually fine once you feel better, but return to your normal exercise routine gradually after finishing the course.

This medicine can cause dizziness, drowsiness, confusion, or trouble sleeping in some people. Avoid driving, operating heavy machinery, or working at heights until you know how this medicine affects you. If your job involves safety-sensitive tasks, discuss with your clinician whether you need temporary adjustments. Most people can continue their usual daily activities, but plan for extra rest while your body recovers from the infection.

Do not stop this medicine early unless your clinician tells you to. Complete the full prescribed course even if you feel better, because stopping early can allow the infection to return and can encourage antibiotic resistance. Stop the medicine and seek medical advice immediately if you develop tendon pain or swelling, new numbness or tingling, a severe skin rash, palpitations or fainting, severe diarrhea, yellowing of the eyes or skin, or signs of a severe allergic reaction. If you need to stop for any other reason, contact your clinician first so that an alternative treatment can be arranged if necessary.

This medicine is usually prescribed for short courses, and long-term use is not common outside specialist settings such as drug-resistant tuberculosis treatment. Prolonged or repeated use can increase the risk of antibiotic resistance, gut infections such as Clostridioides difficile, tendon and nerve problems, and changes in blood sugar or heart rhythm. If a long course is needed, your clinician will monitor your kidney function, liver function, blood counts, and heart rhythm as appropriate, and will review the need for continuing treatment regularly.

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[{"medicine":"alevo 250 tablet","class":"Fluoroquinolone","route":"Oral","common_uses":"Sinusitis, bronchitis, pneumonia, urinary tract infections, prostatitis, skin infections","key_note":"Once-daily dosing, broad spectrum, boxed warning for tendon and nerve effects"},{"medicine":"Ciprofloxacin","class":"Fluoroquinolone","route":"Oral or intravenous","common_uses":"Urinary tract infections, gastrointestinal infections, some respiratory infections","key_note":"Twice-daily dosing is common, similar safety concerns"},{"medicine":"Azithromycin","class":"Macrolide","route":"Oral or intravenous","common_uses":"Respiratory infections, some sexually transmitted infections","key_note":"Different side effect profile, no tendon warning"},{"medicine":"Amoxicillin-clavulanate","class":"Beta-lactam with beta-lactamase inhibitor","route":"Oral","common_uses":"Sinusitis, respiratory infections, skin infections, dental infections","key_note":"Often used first-line for many common infections, different allergy profile"}]