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alsiva 80mg tablet - Lurasidone (80mg) medicine

alsiva 80mg tablet - Uses, Price, Side Effects & Substitutes

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Lurasidone (80mg)
๐Ÿญ Alembic Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is alsiva 80mg tablet used for?

Atlura 40 Tablet (Lurasidone) is used to treat NEURO CNS. It contains Lurasidone (80mg), which Antagonist at dopamine D2 and serotonin 5-HT2A receptors; partial agonist at 5-H. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Lurasidone
  • Manufacturer: Alembic Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š alsiva 80mg tablet Uses & Benefits

Schizophrenia; bipolar depression (as monotherapy or adjunctive with lithium/valproate).

Off-label uses: Bipolar mania, major depressive disorder, anxiety disorders, autism-related irritability.

๐Ÿ“‹ Drug Information

Generic Name(s)Lurasidone
Brand NameAtlura 40 Tablet
ManufacturerAlembic Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassAtypical Antipsychotics
Route of AdministrationOral
StorageStore at 20-25ยฐC (68-77ยฐF); protect from moisture and light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; absorption is enhanced with food (approximately 2-fold increase in Cmax and AUC).
DistributionExtensively distributed; volume of distribution is approximately 6173 L.
Protein Binding99% bound to plasma proteins (albumin and alpha-1-acid glycoprotein).
MetabolismPrimarily metabolized by CYP3A4 to two active metabolites (ID-14283 and ID-14326) and other minor metabolites.
Half-LifeApproximately 18-40 hours (mean 29 hours).
ExcretionApproximately 80% excreted in feces and 9% in urine as metabolites.
Bioavailability9-19% (oral); increased with food.
Onset of Action1-2 weeks for therapeutic effect; may take longer for full response.
Peak Plasma Time1-3 hours (fasted); 2-4 hours (with food).
Duration of Action24 hours (once-daily dosing).

How It Works

Antagonist at dopamine D2 and serotonin 5-HT2A receptors; partial agonist at 5-HT1A receptors; antagonist at 5-HT7 receptors.

Mechanism Steps

1Binds to dopamine D2 receptors in mesolimbic pathway, reducing positive symptoms
2Blocks serotonin 5-HT2A receptors in frontal cortex, improving negative symptoms and reducing EPS
3Partial agonism at 5-HT1A receptors contributes to mood stabilization and anxiolysis

๐Ÿ’ก How to Take alsiva 80mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of alsiva 80mg tablet

โœ… Common Side Effects

  • Somnolence
  • Akathisia
  • Nausea
  • Parkinsonism
  • Dizziness
  • Dystonia
  • Weight gain
  • Insomnia
  • Agitation
  • Anxiety

๐Ÿšจ Serious Side Effects

  • Neuroleptic malignant syndrome
  • Tardive dyskinesia
  • Seizures
  • Suicidal thoughts/behaviors
  • Hyperglycemia/diabetes
  • Dyslipidemia
  • Orthostatic hypotension
  • Leukopenia/neutropenia
  • Priapism

โš ๏ธ Rare Side Effects

  • Hepatotoxicity
  • Pancreatitis
  • Rhabdomyolysis
  • Allergic reactions (angioedema)
  • QT prolongation
  • Venous thromboembolism

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Ketoconazole Major Increased lurasidone exposure (AUC up to 9-fold)
Rifampin Major Decreased lurasidone exposure (AUC reduced by 80%)
Diltiazem Moderate Moderate increase in lurasidone levels
Grapefruit juice Minor Slight increase in lurasidone levels

๐Ÿšจ Major Interactions

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)

โšก Moderate Interactions

  • Moderate CYP3A4 inhibitors (e.g., diltiazem, verapamil)
  • Moderate CYP3A4 inducers (e.g., efavirenz, modafinil)

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • St. John's Wort

๐Ÿฝ๏ธ Food Interactions

Take with food (at least 350 calories) to enhance absorption; avoid grapefruit juice.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase CNS depression and side effects.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to lurasidone or any component; concurrent use with strong CYP3A4 inducers or inhibitors.

๐Ÿ“Š Monitoring Parameters

Mental status, blood pressure, heart rate, weight, metabolic parameters (glucose, lipids), EPS, tardive dyskinesia, CBC, liver function.

๐Ÿคฑ Lactation Safety

Not recommended; lurasidone is excreted in animal milk; unknown in humans.

๐Ÿ’Š Overdose Management

Symptomatic and supportive; monitor vital signs, ECG, and mental status; no specific antidote.

โฐ Missed Dose

Take as soon as remembered unless close to next dose; skip missed dose if near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for alsiva 80mg tablet

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Alternative brands with exact same active ingredient (Lurasidone (80mg)):

Medical Note: Always consult your doctor before switching medications.

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