alsartan-h tablet - Losartan (50mg) + Hydrochlorothiazide (12.5mg) medicine

alsartan-h tablet

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🏭 Aristo Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is alsartan-h tablet used for?

This medicine contains Losartan (50mg) + Hydrochlorothiazide (12.5mg) and is used to treat CARDIAC. Losartan blocks angiotensin II AT1 receptors, reducing vasoconstriction and aldosterone secretion; h. Always consult your doctor before use.

  • Generic Name: Losartan + Hydrochlorothiazide
  • Manufacturer: Aristo Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 alsartan-h tablet Uses & Benefits

Hypertension (first-line), especially in patients with left ventricular hypertrophy.

Off-label uses: Diabetic nephropathy, Heart failure (with caution)

📋 Drug Information

Generic Name(s)Losartan + Hydrochlorothiazide
Brand NameAngizaar-H Tablet
ManufacturerAristo Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassAngiotensin II Receptor Blocker + Thiazide Diuretic
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionLosartan is well absorbed orally; hydrochlorothiazide is absorbed with 65-75% bioavailability.
DistributionLosartan distributes widely; hydrochlorothiazide distributes mainly in extracellular fluid.
Protein BindingLosartan: 98.7% bound to albumin; hydrochlorothiazide: 40-68% bound.
MetabolismLosartan undergoes first-pass metabolism to active metabolite E-3174; hydrochlorothiazide is not metabolized.
Half-LifeLosartan: 2 hours; E-3174: 6-9 hours; hydrochlorothiazide: 6-15 hours.
ExcretionLosartan and metabolite: renal and biliary; hydrochlorothiazide: renal (70% unchanged).
BioavailabilityLosartan: 33%; hydrochlorothiazide: 65-75%.
Onset of ActionLosartan: 1 hour; hydrochlorothiazide: 2 hours.
Peak Plasma TimeLosartan: 1 hour; E-3174: 3-4 hours; hydrochlorothiazide: 1-5 hours.
Duration of ActionLosartan: 24 hours; hydrochlorothiazide: 6-12 hours.

How It Works

Losartan blocks angiotensin II AT1 receptors, reducing vasoconstriction and aldosterone secretion; hydrochlorothiazide inhibits sodium reabsorption in distal tubule, reducing plasma volume.

Mechanism Steps

1Losartan selectively blocks AT1 receptors, preventing angiotensin II binding.
2Reduces vasoconstriction and aldosterone secretion, lowering blood pressure.
3Hydrochlorothiazide inhibits sodium-chloride symporter in distal convoluted tubule.
4Increases sodium and water excretion, reducing plasma volume and blood pressure.
5Combined effect results in synergistic antihypertensive action.

💡 How to Take alsartan-h tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of alsartan-h tablet

✅ Common Side Effects

Dizziness
Headache
Fatigue
Cough
Hyperglycemia
Hypokalemia
Hyperuricemia

🚨 Serious Side Effects

Angioedema
Renal failure
Hepatotoxicity
Severe hypotension
Electrolyte imbalance

⚠️ Rare Side Effects

Pancreatitis
Blood dyscrasias
Anaphylaxis
Photosensitivity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Lithium Major Increased lithium toxicity risk
ACE inhibitors Major Increased risk of hypotension and renal impairment
Aliskiren Major Increased risk of renal impairment, hypotension, and hyperkalemia
Potassium-sparing diuretics Major Increased risk of hyperkalemia
NSAIDs Major Reduced antihypertensive effect and increased renal risk
Alcohol Moderate Increased orthostatic hypotension
Barbiturates Moderate Increased orthostatic hypotension
Corticosteroids Moderate Increased hypokalemia risk
Insulin Moderate Altered glucose control
Oral hypoglycemics Moderate Altered glucose control
Cholestyramine Minor Reduced absorption of hydrochlorothiazide
Colestipol Minor Reduced absorption of hydrochlorothiazide
Dofetilide Minor Increased risk of torsades de pointes

🚨 Major Interactions

  • Lithium
  • ACE inhibitors
  • Aliskiren
  • Potassium-sparing diuretics
  • NSAIDs

⚡ Moderate Interactions

  • Alcohol
  • Barbiturates
  • Corticosteroids
  • Insulin
  • Oral hypoglycemics

🍷 Alcohol Interaction

May potentiate orthostatic hypotension.

🛡️ Safety & Warnings

🚫 Contraindications

Anuria, hypersensitivity to sulfonamides, severe renal impairment (CrCl

🤱 Lactation Safety

Avoid; hydrochlorothiazide may suppress lactation.

💊 Overdose Management

Symptomatic and supportive; monitor electrolytes, blood pressure, and renal function. Induce emesis or gastric lavage if recent.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.

🔄 Substitutes for alsartan-h tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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