alrof 12.5mg tablet - Uses, Price, Side Effects & Substitutes
What is alrof 12.5mg tablet used for?
Alrof (Rofecoxib) is used to treat PAIN ANALGESICS. It contains Rofecoxib (12.5mg), which Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthes. Always consult your doctor before use. Take as prescribed.
- Generic Name: Rofecoxib
- Manufacturer: Albert David Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ alrof 12.5mg tablet Uses & Benefits
Osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea.
Off-label uses: Ankylosing spondylitis, gout, migraine.
๐ Drug Information
| Generic Name(s) | Rofecoxib |
| Brand Name | Alrof |
| Manufacturer | Albert David Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's -Selective COX-2 Inhibitors |
| Route of Administration | Oral. |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis.
Mechanism Steps
๐ก How to Take alrof 12.5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of alrof 12.5mg tablet
โ Common Side Effects
- Dyspepsia
- Nausea
- Diarrhea
- Headache
- Dizziness
- Edema
๐จ Serious Side Effects
- GI bleeding
- Perforation
- Myocardial infarction
- Stroke
- Hypertension
- Renal failure
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Hepatitis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Major | Increased risk of GI ulceration and bleeding |
| Methotrexate | Major | Increased methotrexate toxicity |
| Lithium | Major | Increased lithium levels and toxicity |
| ACE inhibitors | Major | Reduced antihypertensive effect |
| Diuretics | Major | Reduced diuretic effect |
| Corticosteroids | Moderate | Increased risk of GI ulceration |
| Anticoagulants | Moderate | Increased bleeding risk |
| Antiplatelet agents | Moderate | Increased bleeding risk |
| SSRIs | Moderate | Increased bleeding risk |
| Antacids | Minor | Slight decrease in absorption |
| Cimetidine | Minor | No significant interaction |
๐จ Major Interactions
- Warfarin
- Aspirin
- Methotrexate
- Lithium
- ACE inhibitors
- Diuretics
โก Moderate Interactions
- Corticosteroids
- Anticoagulants
- Antiplatelet agents
- SSRIs
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
May increase risk of gastrointestinal bleeding.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to rofecoxib or NSAIDs; history of asthma, urticaria; active GI bleeding; severe renal impairment; pregnancy (third trimester); coronary artery bypass graft surgery.
๐ Monitoring Parameters
Renal function, liver function, blood pressure, signs of GI bleeding, cardiovascular status.
๐คฑ Lactation Safety
Not recommended; excreted in breast milk.
๐ Overdose Management
Symptomatic and supportive care; no specific antidote; consider activated charcoal if recent ingestion.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for alrof 12.5mg tablet
View AllAlternative brands with exact same active ingredient (Rofecoxib (12.5mg)):
-
koxiflam 12.5mg tabletBiological E Ltd โน6.50 34.3% CHEAPER
-
mobirof 12.5mg tabletShreya Life Sciences Pvt Ltd โน8.00 19.2% CHEAPER
-
Roflash 12.5mg TabletKhandelwal Laboratories Pvt Ltd โน10.25 3.5% COSTLIER
-
Rodiff 12.5mg TabletIpca Laboratories Ltd โน10.26 3.6% COSTLIER
-
Rofcom 12.5mg TabletComed Chemicals Ltd โน10.42 5.3% COSTLIER
-
doloroff 12.5mg tabletIndoco Remedies Ltd โน11.25 13.6% COSTLIER
-
ninja 12.5mg tabletWanbury Ltd โน12.07 21.9% COSTLIER
-
ozex 12.5mg tabletBlue Cross Laboratories Ltd โน12.50 26.3% COSTLIER
-
Rofewal 12.5mg TabletWallace Pharmaceuticals Pvt Ltd โน13.00 31.3% COSTLIER
-
Rofica 12.5mg TabletMicro Labs Ltd โน13.00 31.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.