alrista 50mg tablet - Epalrestat (50mg) medicine

alrista 50mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Macleods Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 23, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿคฐ Pregnancy Category C ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 23, 2026

What is alrista 50mg tablet used for?

Aldonil (Epalrestat) is used to treat ANTI DIABETIC. It contains Epalrestat (50mg), which Inhibits aldose reductase, reducing sorbitol accumulation. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Epalrestat
  • Manufacturer: Macleods Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š alrista 50mg tablet Uses & Benefits

Diabetic neuropathy

Off-label uses: Diabetic retinopathy, Diabetic nephropathy

๐Ÿ“‹ Drug Information

Generic Name(s)Epalrestat
Brand NameAldonil
ManufacturerMacleods Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI DIABETIC
Action ClassAldose reductase inhibitor
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration
DistributionWidely distributed in tissues
Protein Binding>90%
MetabolismHepatic metabolism via reduction and conjugation
Half-Life1-2 hours
ExcretionRenal excretion of metabolites
BioavailabilityNot specified
Onset of ActionWithin 1 hour
Peak Plasma Time1-2 hours
Duration of ActionUp to 8 hours

How It Works

Inhibits aldose reductase, reducing sorbitol accumulation

Mechanism Steps

1Inhibits aldose reductase enzyme
2Reduces conversion of glucose to sorbitol
3Decreases sorbitol accumulation in nerves

๐Ÿ’ก How to Take alrista 50mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of alrista 50mg tablet

โœ… Common Side Effects

  • Nausea
  • Headache
  • Dizziness

๐Ÿšจ Serious Side Effects

  • Hepatic dysfunction
  • Thrombocytopenia

โš ๏ธ Rare Side Effects

  • Stevens-Johnson syndrome
  • Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Insulin Moderate Enhanced hypoglycemic effect

๐Ÿšจ Major Interactions

  • NSAIDs
  • Anticoagulants

โšก Moderate Interactions

  • Insulin
  • Sulfonylureas

โ„น๏ธ Minor Interactions

  • Thiazide diuretics

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

May increase risk of hypoglycemia

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to epalrestat, severe hepatic impairment

๐Ÿ“Š Monitoring Parameters

Blood glucose, liver function tests

๐Ÿคฑ Lactation Safety

Not recommended; excretion in milk unknown

๐Ÿ’Š Overdose Management

Symptomatic and supportive treatment

โฐ Missed Dose

Take as soon as remembered; skip if near next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 23, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for alrista 50mg tablet

View All

Alternative brands with exact same active ingredient (Epalrestat (50mg)):

Medical Note: Always consult your doctor before switching medications.

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