alprotic 333mg/145mg tablet cr - Uses, Price, Side Effects & Substitutes
What is alprotic 333mg/145mg tablet cr used for?
Amvalor Chrono 300 Tablet CR (Sodium Valproate + Valproic Acid) is used to treat NEURO CNS. It contains Sodium Valproate (333mg) + Valproic Acid (145mg), which Increases GABA levels by inhibiting GABA transaminase and succinic semialdehyde . Always consult your doctor before use. Take as prescribed.
- Generic Name: Sodium Valproate + Valproic Acid
- Manufacturer: Cubit Healthcare
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ alprotic 333mg/145mg tablet cr Uses & Benefits
Epilepsy (generalized and partial seizures), bipolar disorder (mania), migraine prophylaxis
Off-label uses: Neuropathic pain, status epilepticus (IV), agitation in dementia
๐ Drug Information
| Generic Name(s) | Sodium Valproate + Valproic Acid |
| Brand Name | Amvalor Chrono 300 Tablet CR |
| Manufacturer | Cubit Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Antiepileptic, Mood Stabilizer |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Increases GABA levels by inhibiting GABA transaminase and succinic semialdehyde dehydrogenase; also blocks voltage-gated sodium channels and T-type calcium channels
Mechanism Steps
๐ก How to Take alprotic 333mg/145mg tablet cr
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of alprotic 333mg/145mg tablet cr
โ Common Side Effects
- Nausea
- Vomiting
- Dizziness
- Somnolence
- Tremor
- Weight gain
- Hair loss
๐จ Serious Side Effects
- Hepatotoxicity
- Pancreatitis
- Thrombocytopenia
- Hyperammonemia
- Teratogenicity
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Agranulocytosis
- Encephalopathy
- Osteoporosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Carbamazepine | Major | Decreased valproate levels; increased carbamazepine epoxide levels |
| Lamotrigine | Major | Increased lamotrigine levels; risk of Stevens-Johnson syndrome |
| Phenytoin | Major | Altered phenytoin levels; may increase or decrease |
| Warfarin | Moderate | Increased anticoagulant effect; monitor INR |
| Aspirin | Moderate | Increased valproate levels; risk of toxicity |
๐จ Major Interactions
- Carbamazepine
- Lamotrigine
- Phenytoin
- Phenobarbital
- Rifampin
- Topiramate
โก Moderate Interactions
- Aspirin
- Warfarin
- Cimetidine
- Erythromycin
- Felbamate
- Fluoxetine
โน๏ธ Minor Interactions
- Antacids
- Charcoal
- Cholestyramine
- Clonazepam
- Diazepam
๐ฝ๏ธ Food Interactions
Food may delay absorption but does not affect extent; avoid grapefruit juice as it may alter metabolism
๐ท Alcohol Interaction
Avoid alcohol; may increase CNS depression and hepatotoxicity risk
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Liver disease, porphyria, known hypersensitivity, urea cycle disorders
๐ Monitoring Parameters
Liver function tests, platelet count, serum valproate levels (therapeutic range 50-100 mcg/mL), CBC, coagulation profile
๐คฑ Lactation Safety
Excreted in breast milk; caution advised; monitor infant for drowsiness
๐ Overdose Management
Supportive care; activated charcoal; hemodialysis may be considered; monitor for CNS depression and respiratory depression
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose