Ampisure Tablet (Sultamicillin 375mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or persistent diarrhea, which may contain blood or mucus
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Unusual bleeding or bruising
- Signs of a severe skin reaction such as spreading rash, blisters, or peeling skin
- Decreased urine output or swelling in the legs or feet
- High fever with chills and worsening of symptoms
If experiencing severe symptoms, call emergency services immediately.
What is amisul 375mg tablet used for?
This medicine is an antibiotic combination of ampicillin and sulbactam used to treat bacterial infections of the respiratory tract, urinary tract, skin, and soft tissues. It works by killing bacteria and blocking their resistance mechanisms. It is available as a 375 mg oral tablet and is usually taken twice daily with food. Complete the full course as prescribed.
- Generic Name: Sultamicillin tosilate
- Manufacturer: Cubit Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amisul 375mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीबायोटिक है जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है, जैसे कि श्वसन तंत्र, मूत्र मार्ग, त्वचा और कोमल ऊतकों के संक्रमण। यह सल्टामिसिलिन टोसिलेट 375 मिलीग्राम टैबलेट के रूप में उपलब्ध है और इसे आमतौर पर भोजन के साथ दिन में दो बार लिया जाता है। यह दवा बैक्टीरिया को मारती है और उनके प्रतिरोध तंत्र को रोकती है। इसका पूरा कोर्स डॉक्टर के निर्देशानुसार पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द और त्वचा पर चकत्ते शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज एलर्जी प्रतिक्रिया, जैसे सांस लेने में कठिनाई, चेहरे या गले में सूजन, और गंभीर दस्त शामिल हो सकते हैं। यदि आपको कोई गंभीर या असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले, अपने डॉक्टर को बताएं यदि आपको पेनिसिलिन, सेफलोस्पोरिन या किसी अन्य एंटीबायोटिक से एलर्जी है। आप जो अन्य दवाएं ले रहे हैं, उनके बारे में भी बताएं। इस दवा को भोजन के साथ लें ताकि पेट की परेशानी कम हो। पूरा कोर्स पूरा करें, भले ही आपको कुछ दिनों में बेहतर महसूस हो। यदि आपको दाने, खुजली या सांस लेने में कठिनाई हो, तो दवा बंद करें और तुरंत डॉक्टर से मिलें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 amisul 375mg tablet Uses & Benefits
[{"condition":"Upper respiratory tract infections","description":"Used to treat bacterial infections such as sinusitis, pharyngitis, and tonsillitis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Lower respiratory tract infections","description":"Effective against community-acquired pneumonia and acute exacerbations of chronic bronchitis when caused by beta-lactamase-producing bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Prescribed for uncomplicated and complicated urinary tract infections caused by susceptible strains of Escherichia coli, Klebsiella, and other organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for cellulitis, abscesses, and wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"May be used in some regions for the treatment of uncomplicated gonorrhea, though resistance patterns vary.","evidence":"Limited"}]
Off-label uses: [{"condition":"Dental infections","description":"Sometimes prescribed off-label for dental abscesses or pericoronitis when caused by susceptible bacteria.","evidence":"Limited"},{"condition":"Animal bites","description":"May be used off-label for prophylaxis or treatment of infected animal bites, though other antibiotics are often preferred.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Gonorrhea
📋 Drug Information
| Generic Name(s) | Sultamicillin tosilate |
| Brand Name | Ampisure Tablet |
| Manufacturer | Cubit Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Ampicillin & Sulbactam ester compound |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by combining ampicillin, a broad-spectrum penicillin antibiotic, with sulbactam, a beta-lactamase inhibitor. Ampicillin kills bacteria by binding to penicillin-binding proteins on the bacterial cell wall, inhibiting cell wall synthesis and leading to bacterial death. However, many bacteria produce beta-lactamase enzymes that inactivate ampicillin. Sulbactam irreversibly binds to these enzymes, protecting ampicillin from degradation and extending its spectrum of activity against beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take amisul 375mg tablet
Strength: Sultamicillin tosilate 375 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 375 mg to 750 mg taken orally twice daily, depending on the type and severity of the infection. For more severe infections, a higher dose may be prescribed. The duration of treatment varies from 5 to 14 days, depending on the infection. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can increase the risk of side effects. Dose adjustment may be necessary based on renal function. Consult your doctor for individualized dosing. |
| Renal Impairment | In patients with renal impairment (creatinine clearance less than 30 mL/min), the dosing interval should be increased or the dose reduced. For creatinine clearance 15-29 mL/min, the usual dose may be given every 12 hours. For creatinine clearance less than 15 mL/min, the dose may be given every 24 hours. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but caution is advised. Monitor liver function tests periodically. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 1500 mg (750 mg twice daily) for adults, but this may vary based on the infection and clinical judgment. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amisul 375mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Major | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Aminoglycosides | Moderate | |
| Antacids | Minor | |
| Food | Minor | |
| Grapefruit juice | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Aminoglycosides
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea, vomiting, and abdominal pain. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to penicillins, cephalosporins, or beta-lactam antibiotics","History of severe allergic reaction (e.g., anaphylaxis) to any beta-lactam antibiotic","Infectious mononucleosis (may increase risk of rash)","Severe renal impairment without appropriate dose adjustment"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions have been reported. Before starting therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur. If diarrhea develops, evaluate for this condition and manage appropriately.","Use with caution in patients with renal impairment; dose adjustment may be necessary.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. Monitor for superinfections.","May cause false-positive results in certain urine glucose tests and urine protein tests.","Not effective against viral infections. Do not use for colds or flu."]
🤱 Lactation Safety
Ampicillin and sulbactam are excreted in human breast milk in small amounts. This medicine is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks. Monitor the infant for diarrhea, thrush, or rash.
💊 Overdose Management
Overdose may cause nausea, vomiting, diarrhea, and electrolyte imbalances. There is no specific antidote. Treatment is symptomatic and supportive. Ampicillin and sulbactam can be removed by hemodialysis in cases of severe overdose, especially in patients with renal impairment.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you are allergic to penicillin, cephalosporins, or any other antibiotics. Tell your doctor about all other medicines you are taking, especially blood thinners, methotrexate, allopurinol, and oral contraceptives, as interactions may occur. Take this medicine with food to reduce stomach upset. Complete the full prescribed course even if you feel better after a few days. Do not share this medicine with others. If you develop a rash, itching, or difficulty breathing, stop the medicine and contact your doctor immediately. If you have kidney or liver problems, your doctor may need to adjust your dose. Avoid alcohol while taking this medicine as it may worsen side effects. If you are pregnant or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function, which can increase the risk of side effects. Dose adjustment may be necessary. Monitor renal function and watch for signs of toxicity. Consult your doctor for individualized dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally considered safe during pregnancy (Category B), but should only be used if clearly needed. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery to prevent or treat surgical site infections. Follow your surgeon's instructions carefully. Inform your surgeon if you are taking this medicine before any surgical procedure.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with certain medications used in dentistry. Your dentist may need to adjust your treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine, but if you experience dizziness, fatigue, or muscle pain, avoid strenuous activities. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. If you experience these effects, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal daily activities while taking this medicine.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full prescribed course or as directed by your doctor. If you experience severe side effects such as an allergic reaction, severe diarrhea, or yellowing of the skin or eyes, stop the medicine and seek immediate medical attention. Do not stop prematurely, as it may lead to relapse of the infection.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of antibiotic resistance. Prolonged use may also cause liver enzyme abnormalities and blood dyscrasias. Regular monitoring of liver and kidney function may be required if used for extended periods. It should only be used for the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antibiotic combination that may be used for similar infections.
Evidence: Well-establishedAlternative antibiotics for patients allergic to penicillin.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines such as the typhoid vaccine. Avoid receiving live vaccines during treatment and for several days after stopping this medicine. Inactivated vaccines are generally safe to administer.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually, but maintain even intervals. Check customs regulations for carrying prescription medicines. Carry enough for your entire trip and a few extra doses in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2 to 3 days, but it is important to complete the full course as prescribed.
A: Yes, taking it with food helps reduce stomach upset.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is FDA pregnancy category B, meaning it is generally considered safe, but you should consult your doctor before use.
A: It is advisable to avoid alcohol as it may worsen side effects like nausea and abdominal pain.
🤔 Common Patient Concerns
🔄 Substitutes for amisul 375mg tablet
View AllAlternative brands with exact same active ingredient:
-
myclin 375mg tabletJabs Biotech Pvt Ltd ₹77.00 81.2% CHEAPER
-
betamp 375mg tabletTorrent Pharmaceuticals Ltd ₹170.00 58.5% CHEAPER
-
ampirok 375mg tabletAstrum Healthcare Pvt Ltd ₹174.10 57.5% CHEAPER
-
sulbage 375mg tabletAllenge India ₹192.00 53.2% CHEAPER
-
Talmic 375mg TabletAssociated Biopharma ₹230.00 43.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the common cold.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full prescribed course to ensure the infection is fully cleared and to prevent antibiotic resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This medicine is a prescription antibiotic and should only be taken under the guidance of a qualified healthcare professional.
🔄 Alternative Options
Generic Alternatives
- Sultamicillin tosilate 375 mg tablet
Brand Alternatives
- Ampisure tablet