Alprawin P 0.25mg/20mg Tablet - Uses, Price, Side Effects
What is alprawin p 0.25mg/20mg tablet used for?
Alprawin P 0.25mg/20mg Tablet is a combination of Alprazolam (a benzodiazepine) and Propranolol (a beta-blocker). It is used to treat anxiety disorders with physical symptoms like palpitations and tremors. Alprazolam works by enhancing GABA activity to reduce anxiety, while Propranolol blocks adrenaline effects to lower heart rate and blood pressure. This dual action helps manage both psychological and physiological symptoms.
- Generic Name: Alprazolam + Propranolol
- Manufacturer: Mediwin Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ alprawin p 0.25mg/20mg tablet Uses & Benefits
Anxiety disorders, panic disorder, performance anxiety, essential tremor, situational anxiety
Off-label uses: Insomnia, premenstrual dysphoric disorder, social phobia, migraine prophylaxis
๐ Drug Information
| Generic Name(s) | Alprazolam + Propranolol |
| Brand Name | Ambulax Tablet |
| Manufacturer | Mediwin Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepine + Beta-blocker |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Alprazolam enhances GABA-A receptor activity; Propranolol blocks beta-adrenergic receptors
Mechanism Steps
๐ก How to Take alprawin p 0.25mg/20mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of alprawin p 0.25mg/20mg tablet
โ Common Side Effects
- Drowsiness
- Dizziness
- Fatigue
- Dry mouth
- Nausea
- Constipation
- Bradycardia
- Hypotension
๐จ Serious Side Effects
- Respiratory depression
- Severe bradycardia
- Heart block
- Hypotension
- Seizures
- Suicidal thoughts
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Jaundice
- Agranulocytosis
- Thrombocytopenia
- Stevens-Johnson syndrome
- Bronchospasm
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | Increased sedation and dizziness |
| Cimetidine | Moderate | Increased alprazolam levels |
| Digoxin | Moderate | Increased risk of bradycardia |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP2D6 inhibitors (e.g., quinidine)
- Other CNS depressants
- Calcium channel blockers
- Antiarrhythmics
โก Moderate Interactions
- Oral hypoglycemics
- Theophylline
- Warfarin
- Digoxin
- MAO inhibitors
โน๏ธ Minor Interactions
- Cimetidine
- Oral contraceptives
- Antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice (increases alprazolam levels), High-fat meals may delay absorption
๐ท Alcohol Interaction
Avoid; increased CNS depression and sedation
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, acute narrow-angle glaucoma, severe COPD, asthma, bradycardia, heart block, uncompensated heart failure, myasthenia gravis, severe hepatic impairment
๐ Monitoring Parameters
Heart rate, blood pressure, respiratory rate, sedation level, liver function tests, renal function
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk
๐ Overdose Management
Supportive care; flumazenil for alprazolam overdose; atropine, beta-agonists for propranolol overdose
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Helpful and effective medicine as per my experience. Always consult a doctor.
Good quality medicine. Satisfied with the outcome.
Effective and reliable. Worked as expected.
This medicine was effective for me. I followed the doctor's advice.
Helpful and effective medicine as per my experience. Always consult a doctor.