alporate 500mg tablet

4.7 (14 reviews)

Valproic Acid (500mg)

🏭 Altius Life Sciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is alporate 500mg tablet used for?

Alporate (Valproic Acid) is used to treat NEURO CNS. It contains Valproic Acid (500mg), which Increases GABA levels in the brain by inhibiting GABA transaminase and enhancing. Always consult your doctor before use. Take as prescribed.

Generic Name: Valproic Acid
Manufacturer: Altius Life Sciences
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 alporate 500mg tablet Uses & Benefits

Epilepsy (partial and generalized seizures), bipolar disorder (mania), migraine prophylaxis.

Off-label uses: Neuropathic pain, status epilepticus (IV), borderline personality disorder, aggression in dementia.

📋 Drug Information

Generic Name(s)	Valproic Acid
Brand Name	Alporate
Manufacturer	Altius Life Sciences
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	NEURO CNS
Action Class	Sodium channel modulators (AED)
Route of Administration	Oral
Storage	Store at room temperature (20-25°C); protect from moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly and completely absorbed from the gastrointestinal tract; food may delay absorption but does not affect extent.

DistributionDistributes widely throughout the body; crosses blood-brain barrier and placenta.

Protein BindingApproximately 90% bound to plasma proteins, mainly albumin.

MetabolismExtensively metabolized in the liver via glucuronidation and beta-oxidation; also involves CYP450 enzymes (CYP2C9, CYP2A6).

Half-Life9-16 hours (may be shorter in children and longer in elderly or hepatic impairment).

ExcretionPrimarily excreted in urine as metabolites; less than 3% excreted unchanged.

BioavailabilityApproximately 100% (oral).

Onset of Action1-4 hours for anticonvulsant effect; may take days to weeks for mood stabilization.

Peak Plasma Time1-4 hours (may be delayed with food).

Duration of ActionVariable; typically 8-12 hours.

How It Works

Increases GABA levels in the brain by inhibiting GABA transaminase and enhancing GABA synthesis; also blocks voltage-gated sodium channels and T-type calcium channels.

Mechanism Steps

1Inhibits GABA transaminase, reducing GABA breakdown

2Enhances glutamic acid decarboxylase, increasing GABA synthesis

3Blocks voltage-gated sodium channels, stabilizing neuronal membranes

💡 How to Take alporate 500mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of alporate 500mg tablet

✅ Common Side Effects

Nausea
Vomiting
Dizziness
Somnolence
Tremor
Weight gain
Hair loss
Thrombocytopenia

🚨 Serious Side Effects

Hepatotoxicity
Pancreatitis
Hyperammonemic encephalopathy
Bone marrow suppression
Stevens-Johnson syndrome
QT prolongation

⚠️ Rare Side Effects

Polycystic ovary syndrome
Encephalopathy
Fanconi syndrome
Hypothyroidism
Vasculitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Carbamazepine	Major	Decreased valproate levels; increased risk of carbamazepine toxicity
Lamotrigine	Major	Increased lamotrigine levels; risk of Stevens-Johnson syndrome
Phenytoin	Major	Altered phenytoin levels; increased valproate toxicity
Warfarin	Moderate	Increased bleeding risk
Aspirin	Moderate	Increased valproate levels; bleeding risk
Alcohol	Moderate	Increased CNS depression and hepatotoxicity

🚨 Major Interactions

Carbamazepine
Lamotrigine
Phenytoin
Phenobarbital
Rifampin
Topiramate

⚡ Moderate Interactions

Aspirin
Warfarin
Cimetidine
Erythromycin
Fluoxetine
Felbamate

ℹ️ Minor Interactions

Antacids
Cholestyramine
Oral contraceptives

🍽️ Food Interactions

Food may delay absorption; avoid alcohol.

🍷 Alcohol Interaction

Increased CNS depression and hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to valproate; hepatic disease or significant hepatic dysfunction; known urea cycle disorders; porphyria.

📊 Monitoring Parameters

Liver function tests, platelet count, serum valproate levels (therapeutic range: 50-100 mcg/mL), CBC, coagulation profile.

🤱 Lactation Safety

Valproic acid is excreted in breast milk; caution advised; risk of hepatotoxicity in infant.

💊 Overdose Management

Supportive care; activated charcoal if recent ingestion; hemodialysis may be effective; monitor for CNS depression, respiratory depression, and hepatic toxicity.

⏰ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for alporate 500mg tablet

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Alternative brands with exact same active ingredient (Valproic Acid (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Trusted Reviewer Jul 10, 2026