alpalide 100mg tablet - Nimesulide (100mg) medicine

alpalide 100mg tablet

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🏭 Alpa Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is alpalide 100mg tablet used for?

This medicine contains Nimesulide (100mg) and is used to treat PAIN ANALGESICS. Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis.. Always consult your doctor before use.

  • Generic Name: Nimesulide
  • Manufacturer: Alpa Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 alpalide 100mg tablet Uses & Benefits

Acute pain, dysmenorrhea, postoperative pain, musculoskeletal disorders, fever.

Off-label uses: Not commonly used off-label due to safety concerns.

📋 Drug Information

Generic Name(s)Nimesulide
Brand NameAulin 100mg Tablet
ManufacturerAlpa Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID's-Non-Selective COX 1&2 Inhibitors (Others)
Route of AdministrationOral
StorageStore at room temperature (15-30°C), protect from moisture and light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration, with peak plasma concentrations achieved within 1-3 hours.
DistributionExtensively distributed to tissues; crosses the placenta and enters breast milk.
Protein Binding>97.5% bound to plasma proteins, primarily albumin.
MetabolismExtensively metabolized in the liver via CYP2C9 and other pathways; major metabolite is 4-hydroxynimesulide.
Half-LifeApproximately 1.8-4.7 hours.
ExcretionPrimarily renal (about 50-60% as metabolites, <1% unchanged); also biliary excretion.
BioavailabilityApproximately 100% after oral administration.
Onset of ActionWithin 15-30 minutes.
Peak Plasma Time1-3 hours.
Duration of Action6-8 hours.

How It Works

Selective inhibition of cyclooxygenase-2 (COX-2), reducing prostaglandin synthesis.

Mechanism Steps

1Inhibition of COX-2 enzyme
2Reduction of prostaglandin synthesis from arachidonic acid
3Decreased inflammation, pain, and fever

💡 How to Take alpalide 100mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of alpalide 100mg tablet

✅ Common Side Effects

Nausea
Dyspepsia
Diarrhea
Headache
Dizziness
Rash

🚨 Serious Side Effects

Hepatotoxicity
Gastrointestinal bleeding
Stevens-Johnson syndrome
Acute renal failure
Anaphylaxis

⚠️ Rare Side Effects

Thrombocytopenia
Agranulocytosis
Pancreatitis
Interstitial nephritis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Aspirin Major Increased risk of GI ulceration and bleeding
Methotrexate Major Increased methotrexate toxicity
Lithium Major Increased lithium levels and toxicity
Anticoagulants Major Enhanced anticoagulant effect
ACE inhibitors Moderate Reduced antihypertensive effect
Diuretics Moderate Reduced diuretic effect and increased nephrotoxicity risk
Corticosteroids Moderate Increased risk of GI ulceration
Antiplatelet agents Moderate Increased bleeding risk
Antacids Minor Slight delay in absorption
Cimetidine Minor Possible increased nimesulide levels

🚨 Major Interactions

  • Warfarin
  • Aspirin
  • Methotrexate
  • Lithium
  • Anticoagulants

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Corticosteroids
  • Antiplatelet agents

🍷 Alcohol Interaction

Increased risk of gastrointestinal bleeding and hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to nimesulide or NSAIDs, active peptic ulcer, severe hepatic impairment, severe renal impairment, pregnancy (third trimester), lactation, children

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Symptomatic and supportive; no specific antidote; consider activated charcoal if recent ingestion.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🔄 Substitutes for alpalide 100mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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