alianz 100 mg/20 mg capsule - Diclofenac (100mg) + Rabeprazole (20mg) medicine

Alianz 100 mg/20 mg Capsule: Complete Medicine Guide

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🏭 Cipla Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac is generally avoided in the third trimester due to risk of premature closure of ductus arteriosus. Rabeprazole should be used only if clearly needed. Consult your doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is alianz 100 mg/20 mg capsule used for?

This medicine is a combination of diclofenac, an anti-inflammatory pain reliever, and rabeprazole, a stomach acid reducer. It is used to treat pain and inflammation in conditions like arthritis while protecting the stomach from ulcers.

  • Generic Name: Diclofenac + Rabeprazole
  • Manufacturer: Cipla Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 alianz 100 mg/20 mg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा डाइक्लोफेनाक और रैबेप्राजोल का संयोजन है, जिसका उपयोग गठिया, जोड़ों के दर्द, सूजन और अन्य सूजन संबंधी स्थितियों के इलाज के लिए किया जाता है। यह पेट की परत की रक्षा करने में भी मदद करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में पेट दर्द, जलन, मतली, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, गुर्दे की समस्या और एलर्जी प्रतिक्रिया शामिल हो सकती है।

सुरक्षा सलाह: इस दवा को भोजन के साथ लें। शराब से बचें। गुर्दे, यकृत या हृदय रोग होने पर डॉक्टर को बताएं। बिना डॉक्टर की सलाह के लंबे समय तक न लें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 alianz 100 mg/20 mg capsule Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps manage pain and inflammation associated with ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Provides short-term relief for acute injuries, strains, and sprains.","evidence":"Well-established"},{"condition":"Gastroprotection in NSAID users","description":"Rabeprazole component reduces the risk of NSAID-induced gastric ulcers.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label for preventing migraines, though evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, but not a first-line option.","evidence":"Limited"}]

Primary treatment for: Osteoarthritis

Also treats: Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal pain

📋 Drug Information

Generic Name(s)Diclofenac + Rabeprazole
Brand NameAlianz 100 mg/20 mg capsule
ManufacturerCipla Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID + Proton Pump Inhibitor
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day.
3
Avoid alcohol while taking this medicine.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-3 hours. Rabeprazole is also rapidly absorbed, with peak levels within 2-5 hours. Food may delay absorption of diclofenac but does not significantly affect the extent of absorption.
DistributionDiclofenac is highly bound to plasma proteins and distributes into synovial fluid. Rabeprazole distributes into gastric parietal cells and other tissues. Both drugs have moderate volumes of distribution.
Protein BindingDiclofenac is approximately 99% bound to plasma proteins, primarily albumin. Rabeprazole is about 96% bound to plasma proteins.
MetabolismDiclofenac is metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C9, to several metabolites. Rabeprazole is metabolized in the liver primarily by CYP2C19 and to a lesser extent by CYP3A4.
Half-LifeThe elimination half-life of diclofenac is approximately 1-2 hours. Rabeprazole has a plasma half-life of about 1-2 hours.
ExcretionDiclofenac metabolites are excreted mainly in urine and bile. Rabeprazole metabolites are excreted primarily in urine.
BioavailabilityDiclofenac has a bioavailability of about 50-60% due to first-pass metabolism. Rabeprazole bioavailability is approximately 52%.
Onset of ActionPain relief typically begins within 30-60 minutes after oral administration. Acid suppression by rabeprazole starts within 1 hour.
Peak Plasma TimeDiclofenac peak plasma levels occur at 2-3 hours; rabeprazole peaks at 2-5 hours.
Duration of ActionPain relief lasts approximately 4-6 hours. Acid suppression lasts up to 24 hours.

How It Works

Diclofenac inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin synthesis and thereby decreasing pain, inflammation, and fever. Rabeprazole irreversibly inhibits the gastric H+/K+-ATPase pump in parietal cells, suppressing both basal and stimulated gastric acid secretion, which protects the stomach from diclofenac-induced damage.

Mechanism Steps

1
COX inhibition by diclofenac: Diclofenac binds to and inhibits cyclooxygenase enzymes, blocking the conversion of arachidonic acid to prostaglandins.
2
Reduced prostaglandin synthesis: Lower prostaglandin levels decrease pain signaling, inflammation, and fever.
3
Proton pump inhibition by rabeprazole: Rabeprazole accumulates in acidic parietal cells and irreversibly inhibits the H+/K+-ATPase pump.
4
Suppression of gastric acid secretion: This reduces gastric acidity, protecting the stomach lining from diclofenac-induced irritation and ulceration.

💡 How to Take alianz 100 mg/20 mg capsule

Strength: Capsule containing diclofenac 100 mg and rabeprazole 20 mg.

1Take the capsule whole with a glass of water.
2Swallow it whole; do not crush or chew.
3Take it with food to reduce stomach upset.
4Take at the same time each day.
5Do not take more than prescribed.

Dosage Information

Adult DosageThe usual adult dose is one capsule (diclofenac 100 mg + rabeprazole 20 mg) once daily, preferably with food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of NSAIDs. Use the lowest effective dose for the shortest duration. Monitor renal and gastrointestinal function closely.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseOne capsule per day. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of alianz 100 mg/20 mg capsule

✅ Common Side Effects

Stomach pain (Common (5-10%))
Take with food. If persistent, consult your doctor.
Heartburn (Common (5-10%))
Avoid spicy foods. Report if severe.
Nausea (Common (5-10%))
Take with meals. Stay hydrated.
Headache (Common (5-10%))
Usually resolves. Consult if persistent.
Dizziness (Common (5-10%))
Avoid driving if affected. Consult if severe.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Kidney impairment (Rare (<0.1%))
Report decreased urine output or swelling. Regular monitoring may be needed.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue.
Cardiovascular events (Rare (<0.1%))
Seek emergency care for chest pain, shortness of breath, or weakness.

⚠️ Rare Side Effects

Severe allergic reaction (anaphylaxis)
Seek emergency help for swelling of face, lips, or throat, or difficulty breathing.
Stevens-Johnson syndrome
Seek immediate care for rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
ACE inhibitors Major
Methotrexate Major
Corticosteroids Moderate
Diuretics Moderate
Ketoconazole Moderate
Antacids Minor
Food Minor
Alcohol Major

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • ACE inhibitors
  • Methotrexate

⚡ Moderate Interactions

  • Corticosteroids
  • Diuretics
  • Ketoconazole

🍷 Alcohol Interaction

Alcohol increases the risk of gastrointestinal bleeding and ulceration when taken with this medicine. Avoid alcohol consumption while on this medication.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to diclofenac, rabeprazole, or any component","History of asthma, urticaria, or allergic reaction to NSAIDs","Active peptic ulcer or gastrointestinal bleeding","Severe renal impairment","Severe hepatic impairment","Third trimester of pregnancy","Coronary artery bypass graft surgery"]

⚠️ Warnings & Precautions

["Cardiovascular risk: NSAIDs may increase the risk of serious cardiovascular thrombotic events.","Gastrointestinal risk: NSAIDs can cause ulcers, bleeding, and perforation.","Renal risk: Use with caution in patients with renal impairment.","Hepatic risk: Monitor liver enzymes.","Avoid concurrent use with other NSAIDs.","Use with caution in the elderly."]

🤱 Lactation Safety

Diclofenac and rabeprazole may pass into breast milk. Consult your doctor before use during breastfeeding.

💊 Overdose Management

Overdose may cause nausea, vomiting, abdominal pain, drowsiness, and in severe cases, gastrointestinal bleeding, hypertension, and renal failure. Seek immediate medical attention. Treatment is supportive and symptomatic. Hemodialysis may not be effective due to high protein binding.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor, usually once daily with food to reduce stomach irritation. Do not crush or chew the capsule; swallow it whole. Avoid alcohol and other NSAIDs while on this medicine. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart failure, or high blood pressure. Do not use for more than the recommended duration without medical review. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution and monitor closely.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. This medicine is generally avoided during the third trimester.

🏥 Post-Surgery Considerations

Use with caution after surgery due to increased risk of bleeding. Consult your surgeon.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure due to increased bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid high-impact exercises that may worsen joint pain. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Regular monitoring of kidney and liver function is recommended. Use the lowest effective dose for the shortest duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Weight management

Reduces stress on joints and improves symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. Consult your doctor before any vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, adjust dosing times gradually. Check customs regulations for controlled substances.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old woman with rheumatoid arthritis and a history of gastritis
Was prescribed this combination to manage joint pain while protecting her stomach. She experienced mild nausea initially but it subsided after taking it with meals. Her pain scores improved significantly over a month.
💡 Lesson: The rabeprazole component helps prevent stomach problems, but taking with food further reduces discomfort.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Pain relief typically begins within 30-60 minutes after taking the capsule.

Q: Can I take it on an empty stomach?

A: It is best taken with food to reduce stomach irritation.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for alianz 100 mg/20 mg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken on an empty stomach.
    Fact: It should be taken with food to reduce stomach irritation.
  • Myth: This medicine is safe for everyone.
    Fact: It is not safe for people with certain heart, kidney, or stomach conditions.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac + Rabeprazole combination generics

Brand Alternatives

  • Alianz 100 mg/20 mg capsule

📊 Comparison with Similar Medicines

[{"medicine":"Diclofenac + Rabeprazole","composition":"Diclofenac 100 mg + Rabeprazole 20 mg","onset":"30-60 minutes","duration":"4-6 hours"},{"medicine":"Diclofenac + Omeprazole","composition":"Diclofenac 100 mg + Omeprazole 20 mg","onset":"30-60 minutes","duration":"4-6 hours"}]

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