alcrist 1mg injection - Uses, Price, Side Effects & Substitutes
What is alcrist 1mg injection used for?
Alcrist 1mg Injection (Vincristine) is used to treat ANTI NEOPLASTICS. It contains Vincristine (1mg), which Binds to tubulin, inhibiting microtubule formation and mitotic spindle assembly,. Always consult your doctor before use. Take as prescribed.
- Generic Name: Vincristine
- Manufacturer: Alkem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ alcrist 1mg injection Uses & Benefits
Acute lymphoblastic leukemia, Hodgkin's and non-Hodgkin's lymphoma, Wilms tumor, neuroblastoma, rhabdomyosarcoma.
Off-label uses: Multiple myeloma, chronic lymphocytic leukemia, autoimmune disorders (e.g., ITP).
๐ Drug Information
| Generic Name(s) | Vincristine |
| Brand Name | Alcrist 1mg Injection |
| Manufacturer | Alkem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimicrotubule agents- Vinka alkaloid |
| Route of Administration | Intravenous (IV) only; avoid intrathecal. |
| Storage | Store at 2-8ยฐC; protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Binds to tubulin, inhibiting microtubule formation and mitotic spindle assembly, causing metaphase arrest.
Mechanism Steps
๐ก How to Take alcrist 1mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of alcrist 1mg injection
โ Common Side Effects
- Peripheral neuropathy
- Constipation
- Nausea
- Vomiting
- Alopecia
- Myelosuppression
๐จ Serious Side Effects
- Severe neurotoxicity (motor deficits, paralytic ileus)
- Seizures
- SIADH
- Acute uric acid nephropathy
โ ๏ธ Rare Side Effects
- Pulmonary fibrosis
- Myocardial infarction
- Pancreatitis
- Cortical blindness
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP3A4 inhibitors | Major | Increased vincristine toxicity |
| CYP3A4 inducers | Major | Decreased vincristine efficacy |
| Asparaginase | Major | Increased neurotoxicity |
| Mitomycin C | Major | Increased pulmonary toxicity |
| Digoxin | Moderate | Decreased digoxin absorption |
| Phenytoin | Moderate | Decreased phenytoin levels |
| Warfarin | Moderate | Altered anticoagulation |
| Nifedipine | Minor | Increased vincristine levels |
| Verapamil | Minor | Increased vincristine levels |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
- CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine)
- Asparaginase
- Mitomycin C
- Colony-stimulating factors
โก Moderate Interactions
- Digoxin
- Phenytoin
- Warfarin
โน๏ธ Minor Interactions
- Nifedipine
- Verapamil
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, demyelinating conditions (e.g., Charcot-Marie-Tooth), intrathecal administration (fatal).
๐ Monitoring Parameters
CBC, liver function, renal function, neurologic exam (deep tendon reflexes, motor strength).
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk.
๐ Overdose Management
Supportive care; no specific antidote; consider activated charcoal if oral (unlikely).
โฐ Missed Dose
Administer as soon as possible; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for alcrist 1mg injection
View AllAlternative brands with exact same active ingredient (Vincristine (1mg)):
-
cytocristin aqueous 1mg injectionCipla Ltd โน44.04 15.2% CHEAPER
-
biocristin aq 1mg injectionBiochem Pharmaceutical Industries โน49.65 4.4% CHEAPER
-
vincreta 1mg injectionMetta Life Sciences Private Limited โน51.00 1.8% CHEAPER
-
vincryst 1mg injectionChandra Bhagat Pharma Pvt Ltd โน51.00 1.8% CHEAPER
-
cytocristin 1mg injectionCipla Ltd โน51.13 1.5% CHEAPER
-
biocristin 1mg injectionBiochem Pharmaceutical Industries โน52.63 1.3% COSTLIER
-
onvinc 1mg injectionNeon Laboratories Ltd โน53.28 2.6% COSTLIER
-
vinlon 1mg injectionCelon Laboratories Ltd โน54.00 4% COSTLIER
-
unicristin 1mg injectionUnited Biotech Pvt Ltd โน55.00 5.9% COSTLIER
-
vinrosa 1mg injectionNaprod Life Sciences โน57.00 9.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.