alcof d syrup - Uses, Price, Side Effects & Substitutes
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Medically Reviewed
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💊 What is alcof d syrup used for?
Ascoril D Plus Syrup Sugar Free (Phenylephrine + Chlorpheniramine Maleate) is used to treat Allergic rhinitis. It contains Phenylephrine (5mg/5ml) + Chlorpheniramine Maleate (2mg/5ml), which Phenylephrine: alpha-1 adrenergic agonist causing vasoconstriction; Chlorphenira. Always consult your doctor before use. Take as prescribed.
💊 Generic Name
Phenylephrine + Chlorpheniramine Maleate
Phenylephrine + Chlorpheniramine Maleate
🏭 Manufacturer
Alpic Biotech Ltd
Alpic Biotech Ltd
📦 Form
Allopathy
Allopathy
🤰 Pregnancy Category
Category C
Category C
🇮🇳 alcof d syrup के बारे में संक्षिप्त जानकारी
alcof d syrup का उपयोग मुख्य रूप से respiratory और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Phenylephrine (5mg/5ml) + Chlorpheniramine Maleate (2mg/5ml) मौजूद है।
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.
📋 Complete Drug Information
| Generic Name(s) | Phenylephrine + Chlorpheniramine Maleate |
|---|---|
| Brand Name | Ascoril D Plus Syrup Sugar Free |
| Manufacturer | Alpic Biotech Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Decongestant + Antihistamine |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25°C), protect from light |
🔬 Pharmacology
Pharmacokinetics
AbsorptionRapidly absorbed from gastrointestinal tract
DistributionDistributes widely; crosses blood-brain barrier
Protein BindingPhenylephrine: low; Chlorpheniramine: 70%
MetabolismPhenylephrine: hepatic (MAO); Chlorpheniramine: hepatic (CYP450)
Half-LifePhenylephrine: 2-3 hours; Chlorpheniramine: 12-15 hours
ExcretionRenal (urine)
BioavailabilityPhenylephrine: ~38%; Chlorpheniramine: ~25-50%
Onset of ActionPhenylephrine: 15-30 min; Chlorpheniramine: 30-60 min
Peak Plasma TimePhenylephrine: 1-2 hours; Chlorpheniramine: 2-6 hours
Duration of ActionPhenylephrine: 4-6 hours; Chlorpheniramine: 4-6 hours
Mechanism of Action
Phenylephrine: alpha-1 adrenergic agonist causing vasoconstriction; Chlorpheniramine: H1 receptor antagonist blocking histamine effects
Step-by-Step Mechanism
1
Phenylephrine binds to alpha-1 adrenergic receptors on vascular smooth muscle
2
Causes vasoconstriction in nasal mucosa, reducing congestion
3
Chlorpheniramine blocks H1 receptors on blood vessels and respiratory epithelium
4
Inhibits histamine-mediated vasodilation and increased permeability
5
Reduces sneezing, itching, and rhinorrhea
💡 How to take alcof d syrup
Prescribed Dosage: Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose.
- ✅ Complete the full course of medication.
- ✅ Store at room temperature (20-25°C), protect from light
⚠️ Side Effects of alcof d syrup
✅ Common Side Effects
- Drowsiness
- Dry mouth
- Nausea
- Dizziness
- Headache
🚨 Serious Side Effects
- Hypertension
- Arrhythmias
- Seizures
- Urinary retention
⚠️ Rare Side Effects
- Allergic reactions
- Thrombocytopenia
- Hallucinations
Important: Consult your doctor if you experience any unusual symptoms or severe side effects.
🔬 Drug Interactions
🚨 Major Interactions
- MAOIs
- Beta-blockers
- Tricyclic antidepressants
⚡ Moderate Interactions
- Antihypertensives
- Sympathomimetics
- CNS depressants
🍽️ Food Interactions
Grapefruit juice may increase chlorpheniramine levels
🍷 Alcohol Interaction
Increased CNS depression
🛡️ Safety & Warnings
Pregnancy
Category C
Liver Risk
Low
Kidney Risk
Low
Heart Risk
Low
🚫 Contraindications
Hypertension, Hyperthyroidism, Diabetes, Glaucoma, MAOI use, Severe coronary artery disease
📊 Monitoring Parameters
Blood pressure, Heart rate, CNS effects
🤱 Lactation Safety
Caution; may be excreted in breast milk
💊 Overdose
Symptomatic and supportive; may include activated charcoal, benzodiazepines for seizures
⏰ Missed Dose
Take as soon as remembered; skip if near next dose; do not double