alarm plus 0.5 mg/25 mg tablet - Alprazolam (0.5mg) + Sertraline (25mg) medicine

Alarm Plus 0.5 mg/25 mg Tablet - Uses, Price, Side Effects

4.5 (14 reviews)
๐Ÿญ Organic Laboratories ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is alarm plus 0.5 mg/25 mg tablet used for?

Alarm Plus 0.5 mg/25 mg Tablet is a combination of Alprazolam (a benzodiazepine) and Sertraline (an SSRI). It is used to treat anxiety disorders and depression. Alprazolam works by enhancing the effect of GABA, a calming neurotransmitter, while Sertraline increases serotonin levels to improve mood. This combination helps reduce anxiety and depressive symptoms effectively.

  • Generic Name: Alprazolam + Sertraline
  • Manufacturer: Organic Laboratories
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š alarm plus 0.5 mg/25 mg tablet Uses & Benefits

Generalized anxiety disorder, panic disorder, major depressive disorder with anxiety

Off-label uses: Premenstrual dysphoric disorder, social anxiety disorder

๐Ÿ“‹ Drug Information

Generic Name(s)Alprazolam + Sertraline
Brand NameAlprax Forte 0.5 mg/50 mg Tablet
ManufacturerOrganic Laboratories
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassBenzodiazepine + SSRI
Route of AdministrationOral
StorageStore at 20-25ยฐC, protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAlprazolam: Well absorbed orally; Sertraline: Slowly absorbed, food increases Cmax
DistributionAlprazolam: Vd ~1 L/kg; Sertraline: Vd ~20 L/kg, crosses placenta
Protein BindingAlprazolam: 80%; Sertraline: 98%
MetabolismAlprazolam: Hepatic via CYP3A4; Sertraline: Hepatic via CYP2B6, CYP2C19, CYP2D6, CYP3A4
Half-LifeAlprazolam: 11-16 h; Sertraline: 24-26 h
ExcretionAlprazolam: Renal (80% as metabolites); Sertraline: Renal and fecal
BioavailabilityAlprazolam: 90%; Sertraline: 44% (variable)
Onset of ActionAlprazolam: 1-2 h; Sertraline: 2-4 weeks
Peak Plasma TimeAlprazolam: 1-2 h; Sertraline: 4.5-8.4 h
Duration of ActionAlprazolam: 4-6 h; Sertraline: 24 h

How It Works

Alprazolam: Enhances GABA-A receptor activity; Sertraline: Inhibits serotonin reuptake

Mechanism Steps

1Alprazolam binds to GABA-A receptor benzodiazepine site
2Increases frequency of chloride channel opening
3Enhances GABA inhibitory effects

๐Ÿ’ก How to Take alarm plus 0.5 mg/25 mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of alarm plus 0.5 mg/25 mg tablet

โœ… Common Side Effects

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Nausea
  • Diarrhea
  • Insomnia
  • Fatigue

๐Ÿšจ Serious Side Effects

  • Serotonin syndrome
  • Seizures
  • Suicidal thoughts
  • Severe allergic reactions
  • Angle-closure glaucoma

โš ๏ธ Rare Side Effects

  • QT prolongation
  • Hepatotoxicity
  • Agranulocytosis
  • Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Increased risk of serotonin syndrome
CNS Depressants Major Enhanced sedation and respiratory depression
Warfarin Moderate Increased bleeding risk
Cimetidine Moderate Increased alprazolam levels

๐Ÿšจ Major Interactions

  • MAOIs
  • CYP3A4 inhibitors (e.g., ketoconazole)
  • CYP2D6 inhibitors (e.g., quinidine)
  • Other CNS depressants

โšก Moderate Interactions

  • Cimetidine
  • Oral contraceptives
  • Warfarin
  • NSAIDs

โ„น๏ธ Minor Interactions

  • Antacids
  • Caffeine
  • Smoking

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase alprazolam levels; food increases sertraline Cmax

๐Ÿท Alcohol Interaction

Enhanced CNS depression; avoid alcohol

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Low
Heart
Moderate
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity, acute narrow-angle glaucoma, MAOI use within 14 days, severe hepatic impairment

๐Ÿ“Š Monitoring Parameters

Liver function, renal function, ECG, suicidal ideation, serotonin syndrome symptoms

๐Ÿคฑ Lactation Safety

Excreted in breast milk; avoid breastfeeding

๐Ÿ’Š Overdose Management

Supportive care, flumazenil for alprazolam, serotonin syndrome management

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

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