adicef 200mg tablet - Cefpodoxime Proxetil (200mg) medicine

Adicef 200mg Tablet - Uses, Price, Side Effects

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Cefpodoxime Proxetil (200mg)
🏭 Organic Laboratories 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is adicef 200mg tablet used for?

Adicef 200mg Tablet contains Cefpodoxime Proxetil, a cephalosporin antibiotic that works by stopping the growth of bacteria. It is used to treat various bacterial infections such as respiratory tract infections (like pneumonia, bronchitis), urinary tract infections, skin infections, and ear infections. It is effective against a wide range of gram-positive and gram-negative bacteria.

  • Generic Name: Cefpodoxime Proxetil
  • Manufacturer: Organic Laboratories
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 adicef 200mg tablet Uses & Benefits

Treatment of respiratory tract infections (e.g., community-acquired pneumonia, acute exacerbations of chronic bronchitis), urinary tract infections, skin and soft tissue infections, otitis media, sinusitis, and uncomplicated gonorrhea.

Off-label uses: Lyme disease, Meningococcal prophylaxis, Bacterial endocarditis prophylaxis

📋 Drug Information

Generic Name(s)Cefpodoxime Proxetil
Brand NameAxone O 200mg Tablet
ManufacturerOrganic Laboratories
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporins: 3 generation
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F); protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed from gastrointestinal tract; absorption is enhanced by food.
DistributionDistributes widely into body tissues and fluids including lungs, tonsils, prostate, and middle ear; crosses placenta and enters breast milk.
Protein BindingAbout 21-29% bound to plasma proteins.
MetabolismCefpodoxime proxetil is de-esterified to active cefpodoxime; further metabolism is minimal.
Half-LifeApproximately 2-3 hours in patients with normal renal function.
ExcretionPrimarily excreted unchanged in urine via glomerular filtration and tubular secretion.
BioavailabilityApproximately 50% (increased to 60-70% when taken with food).
Onset of ActionRapid; within 1-2 hours after oral administration.
Peak Plasma Time2-3 hours after oral administration.
Duration of ActionApproximately 12 hours.

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.

Mechanism Steps

1Cefpodoxime proxetil is de-esterified by intestinal esterases to active cefpodoxime.
2Cefpodoxime binds to penicillin-binding proteins (PBPs) located on the bacterial cell wall.
3Inhibition of transpeptidase enzymes prevents cross-linking of peptidoglycan chains.
4Disruption of cell wall synthesis leads to osmotic instability and bacterial cell lysis.
5Bactericidal effect is time-dependent, requiring adequate drug concentration above MIC for a sufficient duration.

💡 How to Take adicef 200mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of adicef 200mg tablet

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Abdominal pain
Headache
Vaginal candidiasis

🚨 Serious Side Effects

Pseudomembranous colitis
Severe allergic reactions (anaphylaxis)
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Seizures

⚠️ Rare Side Effects

Hemolytic anemia
Agranulocytosis
Thrombocytopenia
Interstitial nephritis
Hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Probenecid Moderate Increased cefpodoxime levels
Oral contraceptives Minor Reduced contraceptive efficacy

🚨 Major Interactions

  • Probenecid
  • Warfarin
  • Live typhoid vaccine

⚡ Moderate Interactions

  • BCG vaccine
  • Cholera vaccine
  • Estrogen derivatives
  • Sodium picosulfate

🍷 Alcohol Interaction

No direct interaction reported; however, alcohol may reduce immune response and increase side effects.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cefpodoxime or other cephalosporins; history of immediate-type hypersensitivity to penicillins.

🤱 Lactation Safety

Excreted in breast milk in small amounts; use with caution.

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose and resume regular schedule. Do not double dose.

🔄 Substitutes for adicef 200mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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