akostol tablet - Acotiamide (100mg) medicine

Acogut Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Zydus Cadila 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 22, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Not established from the available information. This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to high for functional dyspepsia.
Reviewed by
SaathiMed Expert Panel | Sep 22, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe allergic reaction: rash, itching, swelling of face, lips, or throat, difficulty breathing.
  • Signs of liver problems: yellowing of skin or eyes, dark urine, severe fatigue.
  • Persistent vomiting or severe abdominal pain.
  • Blood in vomit or stool.
  • Chest pain or palpitations.
  • Sudden weight loss or difficulty swallowing.

If experiencing severe symptoms, call emergency services immediately.

What is akostol tablet used for?

This medicine is an oral tablet containing Acotiamide 100 mg, used to treat functional dyspepsia. It works by improving gastric motility and reducing stomach sensitivity. It is taken three times a day before meals, as prescribed by a doctor.

  • Generic Name: Acotiamide
  • Manufacturer: Zydus Cadila
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 akostol tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एसिटामाइड 100 मिलीग्राम की गोली है, जिसका उपयोग कार्यात्मक अपच (फंक्शनल डिस्पेप्सिया) के इलाज के लिए किया जाता है। यह पेट की गतिशीलता को बढ़ाकर और पेट की संवेदनशीलता को कम करके लक्षणों जैसे भोजन के बाद पेट भरा हुआ महसूस होना, जल्दी पेट भर जाना, और ऊपरी पेट में दर्द या जलन को कम करने में मदद करती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में सिरदर्द, दस्त, कब्ज, पेट दर्द और जी मिचलाना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको त्वचा पर चकत्ते, खुजली, चेहरे, होंठ या गले में सूजन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से लीवर या किडनी की समस्या, हृदय रोग, या किसी भी एलर्जी के बारे में। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो डॉक्टर से परामर्श किए बिना यह दवा न लें। इस दवा को लेते समय शराब का सेवन न करें। दवा को हमेशा डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन से पहले दिन में तीन बार। गोली को चबाएं नहीं, पूरा निगल लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 akostol tablet Uses & Benefits

[{"condition":"Functional dyspepsia","description":"This medicine is used to relieve symptoms of functional dyspepsia, including postprandial fullness, early satiation, and epigastric pain or burning, by improving gastric motility and reducing visceral hypersensitivity.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Gastroparesis","description":"This medicine may sometimes be prescribed off-label to improve gastric emptying in patients with gastroparesis, although evidence is limited and it is not approved for this indication.","evidence":"Limited"},{"condition":"Functional dyspepsia with overlapping irritable bowel syndrome","description":"In some cases, this medicine may be used off-label for patients with overlapping functional dyspepsia and irritable bowel syndrome, but this is not a standard approved use.","evidence":"Limited"}]

Primary treatment for: Functional dyspepsia

Also treats: Gastroparesis, Irritable bowel syndrome

📋 Drug Information

Generic Name(s)Acotiamide
Brand NameAcogut Tablet
ManufacturerZydus Cadila
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAnticholinesterase-Prokinetic agent
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine 15-30 minutes before meals for best results.
2
Do not crush or chew the tablet; swallow it whole with water.
3
If you experience dizziness, avoid driving or operating heavy machinery.
4
Inform your doctor if you have liver or kidney problems before starting this medicine.
5
Avoid alcohol while taking this medicine as it may worsen your symptoms.
6
If symptoms do not improve within 4 weeks, consult your doctor for re-evaluation.
7
Do not share this medicine with others, even if they have similar symptoms.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Postprandial fullness
This medicine is commonly prescribed for this symptom of functional dyspepsia.
Likely Use
Early satiety
This medicine helps improve early satiety by enhancing gastric emptying.
Likely Use
Epigastric pain
This medicine reduces visceral hypersensitivity, alleviating epigastric pain.
Likely Use
Heartburn
This medicine is not primarily used for heartburn or acid reflux.
Not Primary
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionFollowing oral administration, this medicine is absorbed from the gastrointestinal tract. The absolute bioavailability is not well established from the available information. Food does not appear to significantly affect the extent of absorption, but taking it before meals may enhance its prokinetic effects.
DistributionThis medicine is distributed throughout the body, but its primary site of action is the gastrointestinal tract. The volume of distribution is not established from the available information. It is not known whether it crosses the blood-brain barrier or placenta.
Protein BindingThe plasma protein binding of this medicine is not established from the available information.
MetabolismThis medicine undergoes extensive metabolism in the liver, primarily via multiple cytochrome P450 enzymes including CYP3A4, CYP2D6, and others. The exact metabolic pathways and metabolites are not fully characterised from the available information.
Half-LifeThe elimination half-life of this medicine is approximately 1.5 to 2 hours in healthy adults, but this may be prolonged in patients with hepatic impairment.
ExcretionThis medicine and its metabolites are primarily excreted in the urine and faeces. The exact proportion excreted via each route is not established from the available information.
BioavailabilityThe absolute bioavailability of this medicine is not established from the available information.
Onset of ActionThe onset of action for symptom relief may be within a few days, but full therapeutic effects may take up to 2 to 4 weeks of regular use.
Peak Plasma TimeThe peak plasma concentration of this medicine is reached approximately 1 to 2 hours after oral administration.
Duration of ActionThe duration of action of this medicine is not precisely established, but its effects on gastric motility may last for several hours after each dose.

How It Works

This medicine works by inhibiting acetylcholinesterase, the enzyme responsible for breaking down acetylcholine, in the gastrointestinal tract. This inhibition leads to increased levels of acetylcholine, which in turn enhances gastric motility and accelerates gastric emptying. Additionally, this medicine has been shown to reduce visceral hypersensitivity, thereby decreasing the perception of pain and discomfort arising from the stomach and intestines. The effect is primarily local in the gut, with minimal systemic cholinergic effects, which contributes to its favourable safety profile compared to other prokinetic agents.

Mechanism Steps

1
Inhibition of acetylcholinesterase: This medicine binds to and inhibits the enzyme acetylcholinesterase in the gastrointestinal tract, preventing the breakdown of acetylcholine.
2
Increased acetylcholine levels: As a result of enzyme inhibition, acetylcholine accumulates in the synaptic cleft and at neuromuscular junctions within the gut wall.
3
Enhanced gastric motility: The elevated acetylcholine stimulates muscarinic receptors on smooth muscle cells, leading to increased gastric contractions and accelerated gastric emptying.
4
Reduced visceral hypersensitivity: This medicine also modulates the sensitivity of afferent nerve fibres in the gut, reducing the perception of pain and discomfort associated with gastric distension.

💡 How to Take akostol tablet

Strength: Acotiamide 100 mg immediate-release tablet

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Do not crush, chew, or break the tablet.
4Take it before meals, preferably 15-30 minutes before eating.
5If you miss a dose, follow the missed dose instructions.
6Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe recommended adult dose of this medicine is 100 mg taken orally three times a day, preferably before meals. The dose may be individualized by a qualified clinician based on the patient's response and tolerability. It is important to take this medicine exactly as prescribed. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients based on age alone. However, because elderly patients may have reduced hepatic or renal function, caution should be exercised and dose adjustment may be considered by a clinician.
Renal ImpairmentThe safety and efficacy of this medicine in patients with renal impairment have not been established. Caution is advised in patients with severe renal impairment. Dose adjustment may be necessary based on clinical judgment.
Hepatic ImpairmentIn patients with mild to moderate hepatic impairment, no dose adjustment is typically required. However, in severe hepatic impairment, the medicine should be used with caution and dose reduction may be considered. Consult your doctor for specific guidance.
Maximum Daily DoseThe maximum recommended daily dose is 300 mg (100 mg three times a day).

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Meals
Take 15-30 minutes before meals
Enhances prokinetic effect and improves absorption.
Alcohol
Avoid
May worsen symptoms and increase side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of akostol tablet

✅ Common Side Effects

Headache (Common (1-10%))
Usually resolves on its own. If persistent or severe, consult your doctor.
Diarrhoea (Common (1-10%))
Stay hydrated. If it persists for more than 2 days or is severe, contact your doctor.
Constipation (Common (1-10%))
Increase fibre and fluid intake. If it persists, consult your doctor.
Abdominal pain (Common (1-10%))
Take the medicine with food. If pain is severe or persistent, seek medical advice.
Nausea (Common (1-10%))
Take the medicine before meals. If nausea is bothersome, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of the face, lips, or throat, or difficulty breathing.
Liver enzyme elevation (Rare (<0.1%))
Your doctor may monitor liver function tests. Report any yellowing of the skin or eyes, dark urine, or severe fatigue.

⚠️ Rare Side Effects

Palpitations
Consult your doctor if you experience a racing or pounding heartbeat.
Dizziness
Avoid driving or operating machinery until you know how this medicine affects you.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Atropine Major
Ketoconazole Moderate
Rifampicin Moderate
Metoclopramide Minor

🚨 Major Interactions

  • Anticholinergic drugs (e.g., atropine, hyoscyamine)

⚡ Moderate Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine)

🍷 Alcohol Interaction

Alcohol may worsen the symptoms of functional dyspepsia and could increase the risk of gastrointestinal side effects. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to Acotiamide or any component of the formulation","Known allergy to the medicine","Patients with a history of gastrointestinal obstruction or perforation","Severe hepatic impairment","Children under 18 years of age (safety and efficacy not established)"]

⚠️ Warnings & Precautions

["Use with caution in patients with hepatic impairment; dose adjustment may be needed.","Use with caution in patients with renal impairment; not extensively studied.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol consumption as it may worsen symptoms.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not exceed the recommended dose.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether this medicine is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a breastfeeding woman. Consult your doctor before use.

💊 Overdose Management

There is no specific antidote for overdose with this medicine. In case of overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Gastric lavage may be considered if the overdose is recent and the patient is symptomatic.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

Additional Safety Advice

General Safety

Before starting this medicine, inform your doctor about all your medical conditions, especially liver or kidney problems, heart disease, or any allergies. Do not take this medicine if you are pregnant, planning to become pregnant, or breastfeeding without consulting your doctor. Avoid consuming alcohol while taking this medicine, as it may worsen stomach symptoms and increase the risk of side effects. Take this medicine exactly as prescribed, usually three times a day before meals. Do not crush, chew, or break the tablet; swallow it whole with a glass of water. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one. Store this medicine at room temperature, away from moisture and direct sunlight. Keep it out of reach of children and pets. Do not share this medicine with others, even if they have similar symptoms. Regular follow-up with your doctor is important to monitor your response and adjust the dose if needed.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may have reduced liver or kidney function, which can affect the metabolism and excretion of this medicine. Caution is advised, and dose adjustment may be necessary. Regular monitoring for side effects is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not established, and it should only be used if clearly needed.

🏥 Post-Surgery Considerations

There is limited information on the use of this medicine after surgery. Consult your surgeon or doctor before resuming this medicine post-surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. No specific precautions are known, but it is important for your healthcare provider to be aware of all medications you are taking.

💚 Lifestyle Tips for Better Results

🏃
Eat smaller, more frequent meals to reduce stomach discomfort.
🥗
Avoid trigger foods such as spicy, fatty, or acidic foods.
😴
Practice stress-reduction techniques like yoga or meditation.
💧
Get regular physical activity to improve digestion.
🧘
Avoid smoking and limit alcohol consumption.
🌞
Maintain a healthy weight.
🚭
Stay well hydrated throughout the day.

🏋️ Exercise Considerations

Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness or fatigue, avoid strenuous activities until you know how the medicine affects you.

🥗 Diet Recommendations

Include high-fibre foods like fruits, vegetables, and whole grains.
Avoid large, heavy meals.
Limit caffeine and carbonated drinks.
Eat slowly and chew food thoroughly.
Stay hydrated with water and clear fluids.

💼 Impact on Daily Work & Life

This medicine may cause dizziness in some people. If affected, avoid driving or operating heavy machinery until you know how it affects you. Otherwise, it should not significantly impact your daily work or activities.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will advise whether to continue, adjust the dose, or stop the medicine.

📅 Long-Term Use Effects

Long-term use of this medicine is generally well tolerated. However, regular monitoring of liver function may be advised in some patients. There is no evidence of significant long-term toxicity, but ongoing medical supervision is recommended to ensure safety and efficacy.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary modifications

Eating smaller, low-fat meals and avoiding trigger foods can help manage functional dyspepsia.

Evidence: Well-established
Stress management

Stress reduction techniques such as yoga, meditation, and counselling can improve symptoms.

Evidence: Moderate
Other prokinetic agents

Medicines like metoclopramide or domperidone may be alternatives, but they have different side effect profiles.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. You can receive vaccinations as per your doctor's advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When travelling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If you are crossing time zones, adjust your dosing schedule accordingly, but do not take a double dose. Check the customs regulations of your destination country regarding prescription medications. Always keep your medicine in your carry-on luggage to avoid loss or exposure to extreme temperatures.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with chronic functional dyspepsia
She had been suffering from postprandial fullness and early satiety for over a year. After starting this medicine, she noticed significant improvement in her symptoms within two weeks. She took it regularly before meals and avoided alcohol. She reported mild headache initially, which resolved on its own.
💡 Lesson: Consistent use before meals and lifestyle modifications can greatly improve the effectiveness of this medicine.
👤 A 50-year-old man with functional dyspepsia and mild liver impairment
He was prescribed this medicine but required close monitoring due to his liver condition. His doctor adjusted the dose and monitored liver enzymes regularly. He experienced relief from epigastric pain and did not have any serious side effects.
💡 Lesson: Patients with liver impairment need careful monitoring and dose adjustment while taking this medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start noticing improvement in symptoms within a few days, but it may take 2-4 weeks for full therapeutic effect.

Q: Can I take this medicine with other medications?

A: Inform your doctor about all medications you are taking, as this medicine can interact with certain drugs, especially anticholinergics and CYP3A4 inhibitors or inducers.

Q: Is this medicine safe for long-term use?

A: This medicine is generally safe for long-term use under medical supervision. Regular follow-up with your doctor is recommended.

Q: What should I do if I miss a dose?

A: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for akostol tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure all stomach problems.
    Fact: This medicine is specifically for functional dyspepsia and is not a cure for all gastrointestinal conditions.
  • Myth: This medicine can be taken without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under a doctor's supervision.
  • Myth: This medicine is safe to take during pregnancy.
    Fact: The safety of this medicine during pregnancy is not established. Consult your doctor before use.

🔄 Alternative Options

Brand Alternatives

📊 Comparison with Similar Medicines

[{"medicine":"Acotiamide","class":"Gastroprokinetic","primary_use":"Functional dyspepsia","route":"Oral","common_side_effects":"Headache, diarrhoea, constipation"},{"medicine":"Metoclopramide","class":"Prokinetic","primary_use":"Gastroparesis, nausea","route":"Oral, IV, IM","common_side_effects":"Drowsiness, restlessness, extrapyramidal symptoms"},{"medicine":"Domperidone","class":"Prokinetic","primary_use":"Nausea, vomiting, gastroparesis","route":"Oral","common_side_effects":"Dry mouth, headache, abdominal cramps"}]

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