af-k lotion allopathy (Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v)) - Uses in Hindi, Side Effects, Substitutes & Price in India
af-k lotion allopathy (Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Systopic Laboratories Pvt Ltd. Contains Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v).

af-k lotion - Uses, Price, Side Effects & Substitutes

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🏭 Systopic Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 22, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is af-k lotion used for?

Af-K Lotion (Ketoconazole + Zinc Pyrithione) is used to treat Dandruff. It contains Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v), which Ketoconazole inhibits fungal ergosterol synthesis; Zinc pyrithione disrupts fung. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Ketoconazole + Zinc Pyrithione
  • Manufacturer: Systopic Laboratories Pvt Ltd
  • Medicine Form: Allopathy
  • Pregnancy Category: C

🇮🇳 af-k lotion के बारे में संक्षिप्त जानकारी (Hindi Summary)

af-k lotion का उपयोग मुख्य रूप से derma और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

📋 Drug Information

Generic Name(s)Ketoconazole + Zinc Pyrithione
Brand NameAf-K Lotion
ManufacturerSystopic Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntifungal + Antidandruff
Route of AdministrationTopical
StorageStore at room temperature (20-25°C), protect from light
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption when applied topically
DistributionLocalized to skin and scalp; negligible systemic distribution
Protein BindingNot applicable (topical)
MetabolismNot significantly metabolized systemically
Half-LifeNot applicable (topical)
ExcretionNot applicable (topical)
BioavailabilityNegligible systemic bioavailability
Onset of ActionWithin a few days to weeks
Peak Plasma TimeNot applicable (topical)
Duration of ActionLasts for several days after application

Pharmacodynamics

Mechanism of ActionKetoconazole inhibits fungal ergosterol synthesis; Zinc pyrithione disrupts fungal cell membrane and has antibacterial activity
Target ReceptorFungal CYP51 (lanosterol 14α-demethylase) for ketoconazole; Zinc pyrithione targets multiple cellular processes
Pharmacodynamic EffectsAntifungal, antidandruff, antibacterial

💡 How and when to take af-k lotion?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at room temperature (20-25°C), protect from light

⚙️ How af-k lotion Works

Ketoconazole inhibits fungal ergosterol synthesis; Zinc pyrithione disrupts fungal cell membrane and has antibacterial activity

1 Ketoconazole inhibits lanosterol 14α-demethylase, blocking ergosterol synthesis in fungi
⬇️
2 Zinc pyrithione disrupts fungal cell membrane integrity and inhibits fungal growth
⬇️
3 Combination reduces fungal load and inflammation on scalp

💊 af-k lotion Uses in Hindi (Ke Fayde), Benefits & Indications

Dandruff, seborrheic dermatitis, tinea versicolor

Off-label uses: Tinea capitis, pityriasis rosea

⚠️ What are the side effects of af-k lotion?

✅ Common Side Effects

  • Skin irritation
  • Dryness
  • Pruritus

🚨 Serious Side Effects

  • Allergic reaction
  • Contact dermatitis

⚠️ Rare Side Effects

  • Hair discoloration
  • Oiliness or dryness of hair

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

🍽️ Food Interactions

None

🍷 Alcohol Interaction

None

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to any component

📊 Monitoring Parameters

Clinical improvement, skin irritation

🤱 Lactation Safety

Use with caution; limited data

💊 Overdose Management

Rinse with water; symptomatic treatment

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose

🛑 Myths vs. Facts about af-k lotion

  • Myth: Generic substitutes of af-k lotion are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Ketoconazole (2% w/v) + Zinc pyrithione (1% w/v)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of af-k lotion can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

💬 Real Patient Experiences (Astitva)

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