AE-Nerve Capsule - Uses, Price, Side Effects, and More
What is ae-nerve capsule used for?
AE-Nerve Capsule contains Methylcobalamin (750mcg) and Pregabalin (75mg). It is used to treat neuropathic pain and peripheral neuropathy. Methylcobalamin helps repair nerve cells, while Pregabalin reduces pain signals in the brain. It is commonly prescribed for diabetic neuropathy and postherpetic neuralgia.
- Generic Name: Methylcobalamin + Pregabalin
- Manufacturer: Aadi Health Care
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ ae-nerve capsule Uses & Benefits
Diabetic neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury.
Off-label uses: Generalized anxiety disorder, social anxiety disorder, restless legs syndrome.
๐ Drug Information
| Generic Name(s) | Methylcobalamin + Pregabalin |
| Brand Name | Axogurd-SR Tablet |
| Manufacturer | Aadi Health Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Neurotropic vitamin + Gabapentinoid |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Methylcobalamin: Coenzyme for myelin synthesis; Pregabalin: Binds to alpha2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release.
Mechanism Steps
๐ก How to Take ae-nerve capsule
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of ae-nerve capsule
โ Common Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Constipation
๐จ Serious Side Effects
- Angioedema
- Hypersensitivity reactions
- Suicidal thoughts
- Rhabdomyolysis
- PR interval prolongation
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Hepatotoxicity
- Pancreatitis
- Blood dyscrasias
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Alcohol | Moderate | Increased dizziness and drowsiness |
| Opioid analgesics | Major | Additive CNS depression, respiratory depression risk |
| ACE inhibitors | Moderate | Increased risk of angioedema |
๐จ Major Interactions
- Central nervous system depressants
- Thalidomide
- Angiotensin-converting enzyme inhibitors
โก Moderate Interactions
- Oral hypoglycemics
- Antihypertensives
โน๏ธ Minor Interactions
- Antacids
- H2 blockers
๐ฝ๏ธ Food Interactions
High-fat meal may delay absorption of pregabalin
๐ท Alcohol Interaction
Additive CNS depression; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; severe renal impairment (CrCl <30 mL/min) for pregabalin.
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of hypersensitivity, CNS depression, suicidal ideation.
๐คฑ Lactation Safety
Pregabalin excreted in breast milk; caution advised.
๐ Overdose Management
Supportive care; activated charcoal if recent ingestion; hemodialysis may remove pregabalin.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.