adwin p 125mg/5ml/5mg/5ml syrup

4.5 (13 reviews)

Paracetamol (125mg/5ml) Promethazine (5mg/5ml)

🏭 Thrift Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is adwin p 125mg/5ml/5mg/5ml syrup used for?

Adwin P (Paracetamol + Promethazine) is used to treat RESPIRATORY. It contains Paracetamol (125mg/5ml) + Promethazine (5mg/5ml), which Paracetamol inhibits cyclooxygenase (COX) in the CNS, reducing prostaglandin syn. Always consult your doctor before use. Take as prescribed.

Generic Name: Paracetamol + Promethazine
Manufacturer: Thrift Pharmaceuticals
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 adwin p 125mg/5ml/5mg/5ml syrup Uses & Benefits

Symptomatic relief of fever, pain, and allergic conditions (e.g., rhinitis, urticaria).

Off-label uses: Nausea and vomiting (promethazine), migraine (paracetamol combination).

📋 Drug Information

Generic Name(s)	Paracetamol + Promethazine
Brand Name	Adwin P
Manufacturer	Thrift Pharmaceuticals
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	RESPIRATORY
Action Class	Antipyretic + Antihistamine
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionParacetamol is rapidly and completely absorbed from the GI tract; Promethazine is well absorbed orally.

DistributionParacetamol distributes uniformly into most body tissues; Promethazine distributes widely, crosses blood-brain barrier.

Protein BindingParacetamol: 10-25%; Promethazine: 76-93%

MetabolismParacetamol: hepatic via glucuronidation and sulfation; Promethazine: hepatic via oxidation and conjugation.

Half-LifeParacetamol: 1.5-3 hours; Promethazine: 9-16 hours

ExcretionParacetamol: renal (mostly as metabolites); Promethazine: renal and biliary.

BioavailabilityParacetamol: 60-90%; Promethazine: ~25%

Onset of ActionParacetamol: 30-60 min; Promethazine: 20-30 min

Peak Plasma TimeParacetamol: 0.5-2 hours; Promethazine: 2-4 hours

Duration of ActionParacetamol: 4-6 hours; Promethazine: 4-6 hours

How It Works

Paracetamol inhibits cyclooxygenase (COX) in the CNS, reducing prostaglandin synthesis; Promethazine blocks histamine H1 receptors, suppressing allergic responses.

Mechanism Steps

1Paracetamol inhibits COX enzymes in the CNS, reducing prostaglandin synthesis.

2Decreased prostaglandins lower hypothalamic set-point and reduce pain transmission.

3Promethazine blocks H1 receptors, preventing histamine-mediated vasodilation and bronchoconstriction.

💡 How to Take adwin p 125mg/5ml/5mg/5ml syrup

Follow your doctor's prescription exactly.

⚠️ Side Effects of adwin p 125mg/5ml/5mg/5ml syrup

✅ Common Side Effects

Drowsiness
Dizziness
Dry mouth
Nausea
Constipation

🚨 Serious Side Effects

Hepatotoxicity
Severe allergic reactions
Blood dyscrasias
Extrapyramidal symptoms

⚠️ Rare Side Effects

Jaundice
Pancreatitis
Photosensitivity
Hypotension

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
MAOIs	Major	Increased anticholinergic and CNS depressant effects
CNS depressants	Major	Additive sedation
Alcohol	Major	Increased hepatotoxicity risk
Anticholinergics	Moderate	Additive anticholinergic effects
Anticoagulants	Moderate	Enhanced anticoagulant effect
Hepatotoxic drugs	Moderate	Increased hepatotoxicity risk
Chloramphenicol	Minor	Increased chloramphenicol half-life
Metoclopramide	Minor	Increased absorption of paracetamol

🚨 Major Interactions

MAOIs
CNS depressants
Alcohol

⚡ Moderate Interactions

Anticholinergics
Anticoagulants
Hepatotoxic drugs

ℹ️ Minor Interactions

Chloramphenicol
Metoclopramide

🍽️ Food Interactions

Food may delay absorption of paracetamol; no significant food interaction for promethazine.

🍷 Alcohol Interaction

Increased risk of hepatotoxicity with chronic alcohol use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to any component, severe hepatic impairment, narrow-angle glaucoma, prostatic hypertrophy, urinary retention.

📊 Monitoring Parameters

Liver function tests (paracetamol), sedation level, anticholinergic effects.

🤱 Lactation Safety

Paracetamol safe; Promethazine excreted in milk, use with caution.

💊 Overdose Management

Immediate medical attention; acetylcysteine for paracetamol overdose; supportive care for promethazine (CNS depression, anticholinergic symptoms).

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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⭐ User Reviews

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.