adoxi 20mg injection combipack - Uses, Price, Side Effects & Substitutes
What is adoxi 20mg injection combipack used for?
Adoxi 20mg Injection Combipack (Docetaxel) is used to treat ANTI NEOPLASTICS. It contains Docetaxel (20mg), which Promotes assembly of microtubules and inhibits their disassembly, leading to mit. Always consult your doctor before use. Take as prescribed.
- Generic Name: Docetaxel
- Manufacturer: Adley Formulations
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ adoxi 20mg injection combipack Uses & Benefits
Breast cancer, non-small cell lung cancer, prostate cancer, gastric cancer, head and neck cancer.
Off-label uses: Ovarian cancer, esophageal cancer, bladder cancer.
๐ Drug Information
| Generic Name(s) | Docetaxel |
| Brand Name | Adoxi 20mg Injection Combipack |
| Manufacturer | Adley Formulations |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimicrotubule agents- Taxanes |
| Route of Administration | Intravenous infusion. |
| Storage | Store at 2-8ยฐC; protect from light; do not freeze. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Promotes assembly of microtubules and inhibits their disassembly, leading to mitotic arrest and cell death.
Mechanism Steps
๐ก How to Take adoxi 20mg injection combipack
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of adoxi 20mg injection combipack
โ Common Side Effects
- Neutropenia
- Anemia
- Thrombocytopenia
- Alopecia
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Peripheral neuropathy
- Myalgia
๐จ Serious Side Effects
- Severe neutropenia with fever
- Hypersensitivity reactions
- Fluid retention
- Cardiotoxicity
- Hepatotoxicity
- Severe diarrhea
- Interstitial pneumonitis
โ ๏ธ Rare Side Effects
- Acute myeloid leukemia
- Severe skin reactions
- Capillary leak syndrome
- Pulmonary fibrosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased docetaxel toxicity |
| Rifampin | Major | Decreased docetaxel efficacy |
| Warfarin | Major | Increased bleeding risk |
| Clopidogrel | Moderate | Increased bleeding risk |
| Cisplatin | Moderate | Increased neuropathy risk |
| Doxorubicin | Moderate | Increased cardiotoxicity risk |
| Dexamethasone | Minor | Reduced docetaxel clearance |
| Diphenhydramine | Minor | Reduced docetaxel clearance |
| Grapefruit juice | Minor | Increased docetaxel exposure |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
- Warfarin
โก Moderate Interactions
- Clopidogrel
- Cisplatin
- Doxorubicin
โน๏ธ Minor Interactions
- Dexamethasone
- Diphenhydramine
๐ฝ๏ธ Food Interactions
Grapefruit juice (may increase exposure)
๐ท Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to docetaxel or polysorbate 80; severe hepatic impairment; neutropenia (<1500 cells/mmยณ); pregnancy.
๐ Monitoring Parameters
Complete blood count, liver function tests, renal function, vital signs, infusion reactions.
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk.
๐ Overdose Management
Supportive care; monitor for myelosuppression, mucositis, and neuropathy.
โฐ Missed Dose
Do not double dose; contact physician for rescheduling.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for adoxi 20mg injection combipack
View AllAlternative brands with exact same active ingredient (Docetaxel (20mg)):
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dc fill 20mg injectionFourrts India Laboratories Pvt Ltd โน597.50 77.8% CHEAPER
-
Relidoce 20mg InjectionReliance Formulation Pvt Ltd โน1,200.00 55.4% CHEAPER
-
docax 20mg injectionNeon Laboratories Ltd โน1,284.30 52.3% CHEAPER
-
docetax 20mg injectionCipla Ltd โน1,650.00 38.7% CHEAPER
-
innotubilin 20mg injectionInnova Formulations Pvt Ltd โน1,895.63 29.5% CHEAPER
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doxel 20mg injectionShantha Biotech โน2,193.44 18.5% CHEAPER
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Tubitere 20mg InjectionAlkem Laboratories Ltd โน2,330.86 13.4% CHEAPER
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docet 20mg injectionSamarth Life Sciences Pvt Ltd โน2,393.35 11% CHEAPER
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es doce 20mg injectionEsperer Bioresearch Pvt Ltd โน2,603.44 3.2% CHEAPER
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docetere 20mg injectionDr Reddy's Laboratories Ltd โน2,686.03 0.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.