adicoff p syrup - Chlorpheniramine Maleate (NA) + Bromhexine (NA) medicine

Adicoff P Syrup: Complete Medicine Guide

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🏭 Admit Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 18, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for individual components; combination evidence is limited.
Reviewed by
SaathiMed Expert Panel | Oct 18, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swallowing
  • Swelling of face, lips, or throat
  • Irregular or rapid heartbeat
  • Severe drowsiness or confusion
  • Blood in vomit or stool
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is adicoff p syrup used for?

This medicine is a combination syrup used to treat cough and cold symptoms associated with allergies. It contains chlorpheniramine, an antihistamine, and bromhexine, a mucolytic. It relieves runny nose, sneezing, and helps loosen mucus. It may cause drowsiness, so avoid driving. Take as prescribed by your doctor.

  • Generic Name: Chlorpheniramine Maleate + Bromhexine
  • Manufacturer: Admit Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 adicoff p syrup के बारे में (Hindi Summary)

उपयोग: यह दवा एलर्जी और सर्दी-खांसी के लक्षणों के इलाज के लिए इस्तेमाल की जाती है। इसमें क्लोरफेनिरामाइन और ब्रोमहेक्सिन होते हैं। यह नाक बहना, छींकना, और खुजली को कम करती है और बलगम को पतला करके खांसी को आसान बनाती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, और पेट खराब होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन अगर आपको सांस लेने में कठिनाई, धड़कन अनियमित, या गंभीर एलर्जी हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 adicoff p syrup Uses & Benefits

[{"condition":"Productive cough with thick mucus","description":"Helps loosen and thin mucus, making it easier to cough out.","evidence":"Well-established"},{"condition":"Allergic rhinitis with cough","description":"Relieves runny nose, sneezing, and watery eyes while reducing cough associated with postnasal drip.","evidence":"Well-established"},{"condition":"Common cold with congestion","description":"Provides symptomatic relief from cough and nasal congestion.","evidence":"Well-established"}]

Off-label uses: []

Primary treatment for: Cough and cold with allergic rhinitis

Also treats: Productive cough, Allergic rhinitis, Common cold

📋 Drug Information

Generic Name(s)Chlorpheniramine Maleate + Bromhexine
Brand NameAdicoff P Syrup
ManufacturerAdmit Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + Expectorant
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid driving or operating heavy machinery until you know how this medicine affects you.
3
Do not consume alcohol while taking this medicine as it increases drowsiness.
4
Do not exceed the prescribed dose or duration of treatment.
5
Consult your doctor if symptoms persist beyond 7 days or worsen.
6
Inform your doctor if you have glaucoma, prostate problems, or breathing difficulties before taking this medicine.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Runny nose
This medicine is commonly prescribed for this.
Likely Use
✅
Sneezing
This medicine is commonly prescribed for this.
Likely Use
✅
Cough with mucus
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Body ache
This medicine is not a pain reliever.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionChlorpheniramine maleate is well absorbed from the gastrointestinal tract after oral administration. Bromhexine is also absorbed orally, but specific bioavailability data for the combination syrup are not established from the available information.
DistributionChlorpheniramine is widely distributed throughout the body, including the central nervous system. Bromhexine distributes to lung tissue and respiratory secretions. Specific distribution data for the combination are not established from the available information.
Protein BindingChlorpheniramine is approximately 70% bound to plasma proteins. Protein binding of bromhexine is not well established from the available information.
MetabolismChlorpheniramine is metabolized in the liver, primarily by cytochrome P450 enzymes. Bromhexine undergoes extensive first-pass metabolism in the liver. Specific metabolic pathways for the combination are not established from the available information.
Half-LifeThe elimination half-life of chlorpheniramine is approximately 12 to 43 hours. The half-life of bromhexine is not well established from the available information.
ExcretionChlorpheniramine and its metabolites are excreted primarily in the urine. Bromhexine metabolites are excreted mainly in the urine. Specific excretion data for the combination are not established from the available information.
BioavailabilityBioavailability of chlorpheniramine is approximately 25% to 50% due to first-pass metabolism. Bioavailability of bromhexine is not well established from the available information.
Onset of ActionOnset of action for chlorpheniramine is typically within 30 to 60 minutes. Onset for bromhexine is not well established from the available information.
Peak Plasma TimePeak plasma concentration of chlorpheniramine is reached in about 2 to 6 hours. Peak plasma time for bromhexine is not well established from the available information.
Duration of ActionDuration of action for chlorpheniramine is approximately 4 to 6 hours. Duration for bromhexine is not well established from the available information.

How It Works

This medicine combines two active ingredients. Chlorpheniramine maleate works by blocking histamine H1 receptors, reducing allergic symptoms. Bromhexine works by increasing the production of serous fluid in the airways, which thins mucus and aids its removal by coughing.

Mechanism Steps

1
Histamine H1 receptor blockade: Chlorpheniramine maleate competitively binds to histamine H1 receptors on effector cells, preventing histamine from triggering allergic responses such as sneezing, itching, and vasodilation.
2
Anticholinergic action: Chlorpheniramine also exhibits anticholinergic properties, which reduce secretions and may contribute to dry mouth and drowsiness.
3
Mucolytic effect of bromhexine: Bromhexine increases the secretion of serous fluid in the respiratory tract, which reduces the viscosity of mucus and promotes its expulsion through coughing.

💡 How to Take adicoff p syrup

Strength: Syrup containing chlorpheniramine maleate and bromhexine. Specific strengths are not provided in the available information.

1Shake the bottle well before each use.
2Use a measuring cup or spoon to measure the exact dose.
3Take the medicine orally with or without food.
4If stomach upset occurs, take with food or milk.
5Do not exceed the recommended dose.
6Wash the measuring cup after each use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5 to 10 mL (one to two teaspoons) taken orally every 6 to 8 hours as needed, not to exceed 4 doses in 24 hours. However, the exact dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and severity of symptoms. Do not self-medicate; follow your doctor's prescription.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the effects of chlorpheniramine, especially drowsiness and anticholinergic effects. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum daily dose should not exceed 4 doses of 10 mL each in 24 hours for adults, but this must be confirmed by a clinician. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases drowsiness and CNS depression.
Grapefruit juice
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of adicoff p syrup

✅ Common Side Effects

Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Usually resolves with continued use.
Dry mouth (Common (5-10%))
Sip water or chew sugarless gum. Consult doctor if persistent.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid sudden movements.
Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset.
Stomach upset (Common (5-10%))
Take with meals. Consult doctor if severe.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of face or throat, or difficulty breathing.
Irregular heartbeat (Rare (<0.1%))
Contact doctor immediately if you notice palpitations or irregular pulse.
Severe drowsiness or confusion (Rare (<0.1%))
Stop the medicine and consult a doctor if you experience excessive sedation or confusion.

⚠️ Rare Side Effects

Blood dyscrasias
Report unusual bruising or bleeding to your doctor.
Liver enzyme elevation
Inform doctor if you notice yellowing of skin or eyes.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major
CNS depressants Major
Anticholinergics Moderate
Beta-agonists Moderate
Antihypertensives Minor
Diuretics Minor

🚨 Major Interactions

  • MAO inhibitors
  • CNS depressants (e.g., alcohol, benzodiazepines, opioids)

⚡ Moderate Interactions

  • Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
  • Beta-agonists (e.g., salbutamol)

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impair motor skills. Combining alcohol with chlorpheniramine can also increase the risk of central nervous system depression.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to chlorpheniramine, bromhexine, or any component of the formulation","Use in newborns or premature infants","Narrow-angle glaucoma","Prostatic hypertrophy with urinary retention","Severe liver disease","Concurrent use with MAO inhibitors"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with asthma, COPD, or other respiratory conditions.","Use with caution in elderly patients due to increased risk of confusion and falls.","Do not use for chronic cough without medical evaluation.","Consult a doctor if symptoms persist beyond 7 days or worsen."]

🤱 Lactation Safety

Chlorpheniramine and bromhexine may pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause severe drowsiness, confusion, tachycardia, hallucinations, and respiratory depression. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while taking this medicine as it can increase drowsiness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use after the expiry date.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the sedative and anticholinergic effects of chlorpheniramine. They may experience increased drowsiness, confusion, and risk of falls. Use with caution and consider lower doses. Consult a doctor for individualized dosing.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, as it may interact with anesthetics and other medications. It may also increase the risk of drowsiness and respiratory depression.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with sedatives used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Get plenty of rest to support recovery.
😴
Use a humidifier to ease breathing.
💧
Avoid exposure to allergens like dust and pollen.
🧘
Wash hands frequently to prevent infections.
🌞
Avoid smoking and secondhand smoke.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you experience drowsiness or dizziness. Light activity is fine if you feel well.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas.
Include vitamin C-rich fruits and vegetables.
Avoid cold and sugary drinks.
Eat light, easily digestible meals.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness, which can affect your ability to drive or operate machinery. Avoid tasks requiring alertness until you know how it affects you. It may also cause dry mouth, so keep water handy.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any severe side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine may lead to tolerance, dependence, and increased risk of side effects such as cognitive impairment. Bromhexine is generally well-tolerated for short-term use. Regular monitoring of liver and kidney function may be advised if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and relieve congestion.

Evidence: Well-established
Saline nasal rinse

Clears nasal passages and reduces allergy symptoms.

Evidence: Well-established
Antihistamine nasal sprays

Targeted relief for allergic rhinitis.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue your regular dosing schedule as advised by your doctor. Do not leave it in a hot car.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies and cough
She was prescribed this medicine for her runny nose and cough. She took it as directed and noticed relief within a day. She experienced mild drowsiness, so she took it at bedtime. She avoided driving after taking it.
💡 Lesson: Taking this medicine at bedtime can help manage drowsiness during the day.
👤 A 50-year-old man with a productive cough
He had a cough with thick mucus. His doctor prescribed this medicine. After two days, his cough became more productive and easier to clear. He made sure to drink plenty of water.
💡 Lesson: Staying hydrated enhances the mucolytic effect of bromhexine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30 to 60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce stomach upset.

Q: Is it safe for children?

A: Pediatric dosing is not established. Consult a pediatrician before giving this medicine to children.

Q: Can I take it with other cold medicines?

A: Consult your doctor before combining with other cold medicines to avoid overlapping ingredients and interactions.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for adicoff p syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure a cold instantly.
    Fact: This medicine only provides symptomatic relief and does not cure the underlying infection.
  • Myth: It is safe to take this medicine for a long time.
    Fact: Prolonged use without medical supervision can lead to side effects and is not recommended.

🔄 Alternative Options

Generic Alternatives

  • Chlorpheniramine + Bromhexine syrup (generic)

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Chlorpheniramine + Bromhexine","primary_use":"Allergic cough and cold","sedation":"Moderate to high"},{"medicine":"Chlorpheniramine + Dextromethorphan","composition":"Chlorpheniramine + Dextromethorphan","primary_use":"Dry cough","sedation":"Moderate"},{"medicine":"Bromhexine + Guaifenesin","composition":"Bromhexine + Guaifenesin","primary_use":"Productive cough","sedation":"Low"}]

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