Addtim Injection (thiamine Vitamin B1): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe rash or hives
- Dizziness or fainting
- Chest pain or palpitations
- Bluish discoloration of lips or skin
If experiencing severe symptoms, call emergency services immediately.
What is addtim injection used for?
This medicine is a thiamine (vitamin B1) injection used to treat thiamine deficiency, which can cause beriberi, Wernicke's encephalopathy, and other neurological and cardiovascular problems. It is given intramuscularly by a healthcare professional.
- Generic Name: Thiamine
- Manufacturer: Arkson Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 addtim injection के बारे में (Hindi Summary)
उपयोग: यह दवा थायमिन (विटामिन बी1) का इंजेक्शन है, जिसका उपयोग थायमिन की कमी के इलाज के लिए किया जाता है। यह बेरीबेरी, वर्निक एन्सेफैलोपैथी और अन्य न्यूरोलॉजिकल समस्याओं में दिया जाता है। यह इंजेक्शन डॉक्टर द्वारा मांसपेशियों में लगाया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा या सूजन शामिल है। कभी-कभी मतली, बेचैनी या गर्मी लग सकती है। गंभीर एलर्जी प्रतिक्रियाएं दुर्लभ हैं लेकिन तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर द्वारा ही लगाई जानी चाहिए। खुद से इंजेक्शन न लगाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब का सेवन न करें क्योंकि इससे थायमिन की कमी बढ़ सकती है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर को बताएं।
💊 addtim injection Uses & Benefits
[{"condition":"Thiamine deficiency","description":"Treats or prevents thiamine deficiency caused by inadequate dietary intake, malabsorption, or increased requirements.","evidence":"Well-established"},{"condition":"Beriberi","description":"Used to treat dry beriberi (neurological) and wet beriberi (cardiovascular) caused by severe thiamine deficiency.","evidence":"Well-established"},{"condition":"Wernicke's encephalopathy","description":"Emergency treatment of Wernicke's encephalopathy, often associated with chronic alcohol use, to prevent progression to Korsakoff syndrome.","evidence":"Well-established"},{"condition":"Korsakoff syndrome","description":"May be used in the management of Korsakoff syndrome, though neurological damage may be irreversible.","evidence":"Limited"}]
Off-label uses: [{"condition":"Leigh's disease","description":"Sometimes used off-label in mitochondrial disorders such as Leigh's disease, but evidence is limited.","evidence":"Limited"},{"condition":"Maple syrup urine disease","description":"May be used as an adjunct in the management of maple syrup urine disease, but not standard.","evidence":"Limited"}]
Primary treatment for: Thiamine deficiency
Also treats: Beriberi, Wernicke's encephalopathy, Korsakoff syndrome
📋 Drug Information
| Generic Name(s) | Thiamine |
| Brand Name | Amintoz Injection |
| Manufacturer | Arkson Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VITAMINS MINERALS NUTRIENTS |
| Action Class | Vitamins |
| Route of Administration | Intramuscular |
| Storage | Store at room temperature (15-30°C). Protect from light and freezing. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Thiamine is converted in the body to its active form, thiamine pyrophosphate (TPP), which serves as a coenzyme for several key enzymes involved in carbohydrate metabolism, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase. These enzymes are essential for the production of energy and for the synthesis of neurotransmitters. By replenishing thiamine, this medicine helps restore normal metabolic function, particularly in the nervous system and heart, where energy demands are high.
Mechanism Steps
💡 How to Take addtim injection
Strength: Thiamine 50 mg/mL injection
Dosage Information
| Adult Dosage | The dosage of this medicine is individualized by a qualified clinician based on the indication, severity of deficiency, and patient's clinical condition. For thiamine deficiency, typical adult doses range from 10 to 100 mg intramuscularly, but higher doses may be used in severe cases such as Wernicke's encephalopathy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal function and overall health status. Consult a doctor for individualized dosing. |
| Renal Impairment | No specific dose adjustment is established for renal impairment, but use with caution and monitor renal function. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but use with caution. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribing clinician based on the patient's condition. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of addtim injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Furosemide | Moderate | |
| Fluorouracil | Moderate |
🚨 Major Interactions
- Alcohol
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Fluorouracil
🍷 Alcohol Interaction
Alcohol consumption should be avoided while receiving this medicine because alcohol reduces thiamine absorption and increases the body's requirement for thiamine, potentially worsening deficiency and reducing the effectiveness of treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to thiamine or any component of the formulation"]
⚠️ Warnings & Precautions
["Administer with caution in patients with a history of allergic reactions to thiamine.","Use with caution in patients with renal impairment; dose adjustment may be needed.","Avoid alcohol consumption during treatment.","Do not administer intravenously; this medicine is for intramuscular use only.","Keep epinephrine available in case of anaphylaxis."]
🤱 Lactation Safety
Thiamine is excreted in breast milk and is considered safe for breastfeeding mothers when used as prescribed. Consult your doctor for guidance.
💊 Overdose Management
Overdose with thiamine is unlikely to cause serious effects due to its water-soluble nature and rapid excretion. However, if a large dose is accidentally administered, monitor the patient for signs of allergic reactions and provide supportive care. In case of severe reactions, treat symptomatically.
⏰ Missed Dose
If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer an extra dose. Your doctor will advise on the next steps.
Additional Safety Advice
This medicine must be administered by a qualified healthcare professional only. Do not attempt to self-administer. Before receiving this injection, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also, disclose any allergies, especially to thiamine or other vitamins. If you have kidney or liver disease, your doctor may need to adjust the dose or monitor you closely. Avoid alcohol consumption while receiving this medicine, as alcohol can worsen thiamine deficiency and reduce its effectiveness. Do not drive or operate heavy machinery immediately after the injection if you feel dizzy or unwell. Keep all follow-up appointments and report any unusual symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and may require dose adjustment. Monitor for signs of deficiency and adverse effects.
🤰 Pregnancy Planning (TTC)
Thiamine is essential during pregnancy. If you are planning pregnancy, ensure adequate intake through diet and supplements as advised by your doctor.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon about this medicine. It is generally safe to continue, but your doctor will advise.
🦷 Dental Procedures
No specific precautions for dental procedures, but inform your dentist about this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are required while on this medicine, but if you experience dizziness or weakness, avoid strenuous activities until you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting and generally does not affect your ability to work or drive. However, if you feel dizzy or unwell after the injection, avoid driving or operating machinery until symptoms resolve.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The duration of treatment depends on the underlying condition and your response. Your doctor will determine when to discontinue or switch to oral therapy.
📅 Long-Term Use Effects
Long-term use of thiamine injection is generally safe when used as prescribed. Prolonged high doses may lead to hypersensitivity reactions in rare cases. Regular monitoring of clinical response is advised. When deficiency is corrected, oral supplementation may be sufficient.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used for mild deficiency or maintenance after initial injection therapy.
Evidence: Well-establishedIncreasing intake of thiamine-rich foods can help prevent deficiency.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, inform your doctor about recent vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from light and freezing. If you need to administer it during travel, ensure you have access to a healthcare professional. Check customs regulations for carrying injectable medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The injection starts working quickly, but clinical improvement may take days to weeks depending on the severity of deficiency.
A: Some pain at the injection site is common but usually mild and temporary.
A: Oral thiamine may be used if absorption is adequate; however, intramuscular is preferred when rapid replenishment is needed or absorption is impaired.
🤔 Common Patient Concerns
🔄 Substitutes for addtim injection
View AllAlternative brands with exact same active ingredient:
-
eritha 100 injectionEridanus Healthcare ₹39.38 30% CHEAPER
-
g-myn injectionNirmalaya Pharmaceutical Pvt Ltd ₹60.00 6.7% COSTLIER
-
thiabion injection 2mlSolvate Laboratries Pvt Ltd ₹275.00 388.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Thiamine injection is a painkiller.
Fact: Thiamine injection is a vitamin supplement used to treat deficiency, not a painkiller. - Myth: Thiamine injection can be self-administered.
Fact: It must be given by a healthcare professional. - Myth: Thiamine injection is only for alcoholics.
Fact: It is used for anyone with thiamine deficiency due to various causes.
🔄 Alternative Options
Generic Alternatives
- Thiamine injection (generic)
Brand Alternatives
- Addtim Injection