Acudol D Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or stool
- Severe abdominal pain
- Irregular heartbeat or palpitations
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Severe headache with visual changes
If experiencing severe symptoms, call emergency services immediately.
What is acudol d tablet used for?
This medicine is a combination of Domperidone and Paracetamol used to treat nausea, vomiting, and mild to moderate pain. It works by improving stomach emptying and reducing pain and fever.
- Generic Name: Domperidone (15mg) + Paracetamol (500mg)
- Manufacturer: Radico Remedies
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acudol d tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और पैरासिटामोल का संयोजन है, जिसका उपयोग मतली, उल्टी और हल्के से मध्यम दर्द और बुखार के इलाज के लिए किया जाता है। यह पेट की गति को बढ़ाकर और दर्द निवारक प्रभाव डालकर काम करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, चक्कर आना, नींद आना और पेट में ऐंठन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन अनियमित दिल की धड़कन, स्तन में दर्द या सूजन, और मांसपेशियों में अकड़न हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे लीवर को नुकसान और नींद आने की समस्या बढ़ सकती है। यदि आपको हृदय, यकृत या गुर्दे की समस्या है तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के 7 दिनों से अधिक इसका उपयोग न करें। बच्चों की पहुंच से दूर रखें।
💊 acudol d tablet Uses & Benefits
[{"condition":"Nausea and vomiting","description":"This medicine helps relieve nausea and vomiting by promoting gastric emptying and blocking dopamine receptors in the chemoreceptor trigger zone.","evidence":"Well-established"},{"condition":"Gastroparesis","description":"It is used to manage symptoms of delayed gastric emptying, such as bloating, nausea, and early satiety.","evidence":"Moderate"},{"condition":"Mild to moderate pain","description":"Paracetamol component provides relief from mild to moderate pain such as headache, muscle ache, and toothache.","evidence":"Well-established"},{"condition":"Fever","description":"Paracetamol helps reduce fever by acting on the hypothalamus.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine-associated nausea","description":"Sometimes prescribed off-label to relieve nausea during migraine attacks.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Gastroparesis, Mild to moderate pain, Fever
📋 Drug Information
| Generic Name(s) | Domperidone (15mg) + Paracetamol (500mg) |
| Brand Name | acudol d tablet |
| Manufacturer | Radico Remedies |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the gastrointestinal tract, leading to increased gastric motility and accelerated gastric emptying. It also acts on the chemoreceptor trigger zone to reduce nausea and vomiting. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which results in analgesic and antipyretic effects. The combination provides both prokinetic and analgesic-antipyretic actions.
Mechanism Steps
💡 How to Take acudol d tablet
Strength: Tablet containing Domperidone 15 mg and Paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally up to three times daily, preferably before meals. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not self-medicate. Follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Consult your doctor. |
| Renal Impairment | In patients with severe renal impairment, the dose of Domperidone may need to be reduced. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction may be necessary. Avoid use in severe hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose of Domperidone should not exceed 30 mg (as per some guidelines, but individualize). Paracetamol maximum daily dose is 4000 mg for adults. However, the combination's maximum daily dose should be determined by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acudol d tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Warfarin | Major | |
| Atropine | Moderate | |
| Opioids | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Ketoconazole, Itraconazole, Clarithromycin
- Warfarin
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., Atropine)
- Opioid analgesics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage from Paracetamol and may enhance drowsiness and dizziness caused by Domperidone.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Domperidone or Paracetamol","Gastrointestinal bleeding, obstruction, or perforation","Prolactin-releasing pituitary tumor (prolactinoma)","Severe hepatic impairment","Known QT prolongation or cardiac conduction disorders","Concomitant use with strong CYP3A4 inhibitors"]
⚠️ Warnings & Precautions
["Use with caution in patients with heart disease or electrolyte imbalances.","Avoid in patients with Parkinson's disease as Domperidone may worsen symptoms.","Do not exceed recommended dose of Paracetamol to avoid liver damage.","Use with caution in elderly patients due to increased risk of side effects.","Avoid alcohol consumption during treatment."]
🤱 Lactation Safety
Domperidone is excreted in breast milk. Limited data suggest it may be used with caution during breastfeeding, but consult your doctor to weigh benefits and risks.
💊 Overdose Management
Overdose may cause severe liver damage from Paracetamol and cardiac arrhythmias from Domperidone. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for Paracetamol toxicity, and supportive care for cardiac effects.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and drowsiness. Inform your doctor if you have heart, liver, or kidney problems before taking this medicine. Do not use this medicine for more than 7 days without consulting a doctor. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects like drowsiness, dizziness, and cardiac arrhythmias. Dose adjustment may be needed based on renal and hepatic function.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy or are pregnant. This medicine should be used only if clearly needed and prescribed by a doctor.
🏥 Post-Surgery Considerations
Use with caution after surgery, especially if you have heart conditions or are taking other medications. Consult your surgeon.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with anesthetics or other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or drowsy after taking this medicine. Light activities like walking are generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms persist beyond 7 days, if you experience severe side effects, or if you have any allergic reactions.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of Domperidone-related cardiac effects and Paracetamol-induced liver damage. Regular monitoring of liver and kidney function is advised. Use for the shortest duration necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating small, frequent meals and avoiding trigger foods can help manage nausea.
Evidence: Well-establishedGinger has natural anti-nausea properties and can be used as a complementary remedy.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, consult your doctor before vaccination if you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: It is best taken 15-30 minutes before meals. If it upsets your stomach, you may take it with food.
A: Consult your doctor before use. It is not recommended without medical advice.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Acudol D Tablet is a strong painkiller.
Fact: It contains Paracetamol, which is a mild analgesic, and Domperidone, which is not a painkiller but helps with nausea. - Myth: It can be taken for any type of pain.
Fact: It is effective for mild to moderate pain but not for severe pain or pain from serious conditions without medical advice.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Paracetamol combination tablets
Brand Alternatives
- Domperidone + Paracetamol tablets