actogod np 75mg/10mg/1500mcg tablet - Uses, Price, Side Effects & Substitutes
What is actogod np 75mg/10mg/1500mcg tablet used for?
Axogurd NT Tablet SR (Pregabalin + Nortriptyline) is used to treat NEURO CNS. It contains Pregabalin (75mg) + Nortriptyline (10mg), which Pregabalin binds to alpha-2-delta subunit of voltage-gated calcium channels, red. Always consult your doctor before use. Take as prescribed.
- Generic Name: Pregabalin + Nortriptyline
- Manufacturer: Godase Healthcare
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ actogod np 75mg/10mg/1500mcg tablet Uses & Benefits
Neuropathic pain, fibromyalgia, generalized anxiety disorder, depression.
Off-label uses: Chronic pain, migraine prophylaxis, social anxiety disorder.
๐ Drug Information
| Generic Name(s) | Pregabalin + Nortriptyline |
| Brand Name | Axogurd NT Tablet SR |
| Manufacturer | Godase Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Gabapentinoid + Tricyclic Antidepressant |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Pregabalin binds to alpha-2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release. Nortriptyline inhibits reuptake of norepinephrine and serotonin, increasing their synaptic concentrations.
Mechanism Steps
๐ก How to Take actogod np 75mg/10mg/1500mcg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of actogod np 75mg/10mg/1500mcg tablet
โ Common Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Constipation
- Blurred vision
- Weight gain
- Peripheral edema
๐จ Serious Side Effects
- Suicidal thoughts
- Serotonin syndrome
- Cardiac arrhythmias
- Seizures
- Angle-closure glaucoma
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Agranulocytosis
- Stevens-Johnson syndrome
- Rhabdomyolysis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CYP2D6 inhibitors | Major | Increased nortriptyline levels, toxicity |
| CNS depressants | Major | Additive sedation, respiratory depression |
| Anticholinergics | Moderate | Increased anticholinergic side effects |
| Antihypertensives | Moderate | Enhanced hypotensive effect |
| Grapefruit juice | Moderate | Increased nortriptyline levels |
๐จ Major Interactions
- MAOIs
- CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)
- CYP3A4 inhibitors (e.g., ketoconazole)
- Other CNS depressants (e.g., benzodiazepines, opioids)
โก Moderate Interactions
- Anticholinergics
- Antihypertensives
- Sympathomimetics
- Cimetidine
- Quinidine
โน๏ธ Minor Interactions
- Oral contraceptives
- Smoking (induces CYP1A2)
๐ฝ๏ธ Food Interactions
Pregabalin: No significant effect; Nortriptyline: Avoid grapefruit juice (CYP3A4 inhibition).
๐ท Alcohol Interaction
Avoid alcohol; increased CNS depression and risk of seizures.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, concurrent MAOI use, severe hepatic impairment, narrow-angle glaucoma, urinary retention.
๐ Monitoring Parameters
ECG, blood pressure, liver function, renal function, serum drug levels (nortriptyline), suicidal ideation.
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Supportive care, activated charcoal, ECG monitoring, benzodiazepines for seizures, sodium bicarbonate for cardiac toxicity.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose.