Activa P Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is activa p tablet used for?
This medicine is a combination of diclofenac and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins that cause pain. Take it with food, avoid alcohol, and do not exceed the prescribed dose.
- Generic Name: Diclofenac + Paracetamol
- Manufacturer: Zydus Healthcare Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 activa p tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह जोड़ों के दर्द, मांसपेशियों के दर्द, दांत दर्द, पीठ दर्द, और मासिक धर्म के दर्द में राहत देती है। यह बुखार को भी कम करती है। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन बिल्कुल न करें। डॉक्टर की सलाह के बिना 7 दिन से अधिक न लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति, और गंभीर एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन या दूध के साथ लें। खाली पेट न लें। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ न लें। यदि आपको पेट अल्सर, गुर्दे, यकृत, हृदय रोग, या अस्थमा है तो डॉक्टर को बताएं। 7 दिन से अधिक उपयोग न करें। बच्चों की पहुंच से दूर रखें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 activa p tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as muscle strains, sprains, and back pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgical procedures.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Osteoarthritis flare-ups","description":"Reduces pain and improves joint mobility during acute exacerbations.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Renal colic","description":"May be used off-label for pain relief in kidney stones, but requires medical supervision.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Dental pain, Post-operative pain
📋 Drug Information
| Generic Name(s) | Diclofenac + Paracetamol |
| Brand Name | At Sp Tablet |
| Manufacturer | Zydus Healthcare Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Diclofenac is a non-selective non-steroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in reduced inflammation, pain, and fever. Paracetamol (acetaminophen) acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesic and antipyretic effects without significant anti-inflammatory action. Together, they provide enhanced pain relief through different pathways.
Mechanism Steps
💡 How to Take activa p tablet
Strength: Diclofenac (NA) + Paracetamol (NA) immediate-release tablet. Exact strengths not specified in the available information.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain, not to exceed 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take more than the prescribed dose. Take with food or milk to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Consult your doctor for individualized dosing. Avoid in severe renal impairment. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | Maximum daily dose: Diclofenac 150 mg and paracetamol 4000 mg. However, the maximum recommended dose of this combination is typically 3 tablets per day, not exceeding the prescribed limit. Do not exceed the dose recommended by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of activa p tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Corticosteroids | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, ibuprofen)
- Corticosteroids
- Methotrexate
- ACE inhibitors and angiotensin receptor blockers
⚡ Moderate Interactions
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Lithium
- SSRIs (e.g., fluoxetine, sertraline)
- Antihypertensives (beta-blockers, calcium channel blockers)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially when combined with paracetamol and diclofenac. It can also worsen drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or history of recurrent ulcers","Severe heart failure","Severe kidney disease","Severe liver disease","Known hypersensitivity to diclofenac, paracetamol, or other NSAIDs","Asthma triggered by aspirin or other NSAIDs","Third trimester of pregnancy","Coronary artery bypass graft surgery (peri-operative period)"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose.","Use with caution in elderly patients due to increased risk of side effects.","Consult your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma.","Do not use for more than 7 days without medical advice.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
Diclofenac and paracetamol are excreted in breast milk in small amounts. Short-term use is generally considered compatible with breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose can cause severe nausea, vomiting, abdominal pain, liver damage, kidney failure, and bleeding. Seek immediate medical attention. Treatment is supportive and symptomatic. For paracetamol overdose, N-acetylcysteine is the antidote and should be administered as soon as possible. For diclofenac overdose, activated charcoal may be used if within 1-2 hours of ingestion. Monitor liver and kidney function, and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with food or milk to minimize stomach irritation. Do not take it on an empty stomach. Avoid alcohol completely while taking this medicine, as it increases the risk of stomach bleeding. Do not take other pain relievers or NSAIDs without consulting your doctor, as this can increase the risk of side effects. If you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma, inform your doctor before taking this medicine. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children. Store at room temperature away from moisture and heat. If you are pregnant or breastfeeding, consult your doctor before use.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly. Avoid in patients with severe renal or hepatic impairment.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning pregnancy. Diclofenac may affect ovulation and is generally avoided in the third trimester. Paracetamol is considered relatively safe but should be used at the lowest effective dose for the shortest duration.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but consult your surgeon before taking it, especially after coronary artery bypass graft surgery where NSAIDs are contraindicated. It may increase bleeding risk.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. It can be used for dental pain, but follow your dentist's advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have pain or inflammation. Gentle stretching and low-impact activities are recommended. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Inform your employer if your work involves operating machinery.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, kidney problems, liver damage, or allergic reactions. Do not stop abruptly if you are on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney problems, liver damage, and cardiovascular events. Regular monitoring of liver and kidney function is recommended. Use the lowest effective dose for the shortest duration. Consult your doctor if you need to use it for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: LimitedSome evidence for chronic pain relief.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep a list of your medications and allergies with you.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30-60 minutes after taking the tablet.
A: No, it should be taken with food or milk to reduce stomach upset.
A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor, as it may increase the risk of side effects.
A: No, alcohol increases the risk of stomach bleeding and liver damage.
A: It is intended for short-term use. Do not use for more than 7 days without medical advice.
🤔 Common Patient Concerns
🔄 Substitutes for activa p tablet
View AllAlternative brands with exact same active ingredient:
-
easypanvin tabletPCI Pharmaceuticals ₹4.50 22.5% CHEAPER
-
reactin pm tabletCipla Ltd ₹4.87 16.2% CHEAPER
-
donn plus tabletAbbott ₹13.13 126% COSTLIER
-
donac plus tabletAxon Drugs Pvt Ltd ₹14.06 142% COSTLIER
-
dicloss p tabletTheo Pharma Pvt Ltd ₹14.06 142% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take on an empty stomach.
Fact: It should be taken with food to reduce the risk of stomach upset and bleeding. - Myth: This medicine can be taken long-term without any risk.
Fact: Long-term use increases the risk of gastrointestinal, kidney, and cardiovascular side effects. Use only as prescribed. - Myth: This medicine is a good choice for fever alone.
Fact: It contains paracetamol which reduces fever, but it is primarily used for pain. For fever alone, paracetamol alone is usually preferred.
🔄 Alternative Options
Generic Alternatives
- Diclofenac + Paracetamol combination tablets from other manufacturers
Brand Alternatives
- Activa P Tablet
- Other brands containing diclofenac and paracetamol