activa p 100 mg/500 mg tablet - Diclofenac (100mg) + Paracetamol (500mg) medicine

Activa P 100 mg/500 mg Tablet: Complete Medicine Guide

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🏭 Zydus Healthcare Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diclofenac is generally avoided during the third trimester due to risk of premature closure of the ductus arteriosus. Paracetamol is considered relatively safe during pregnancy when used at recommended doses. Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for short-term pain relief.
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising
  • Severe skin rash with blisters

If experiencing severe symptoms, call emergency services immediately.

What is activa p 100 mg/500 mg tablet used for?

This medicine is a combination of diclofenac (100 mg) and paracetamol (500 mg) used for short-term relief of moderate to severe pain and inflammation. It works by reducing pain and swelling. Take it with food, avoid alcohol, and do not exceed the prescribed dose.

  • Generic Name: Diclofenac + Paracetamol
  • Manufacturer: Zydus Healthcare Limited
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 activa p 100 mg/500 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डाइक्लोफेनाक 100 मिलीग्राम और पैरासिटामोल 500 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है, जैसे कि मांसपेशियों की चोट, दांत दर्द, ऑपरेशन के बाद का दर्द, और गठिया के दौरे। यह दर्द और सूजन को कम करने में मदद करती है। इसे भोजन के साथ लें और शराब से बचें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट दर्द, जलन, मतली, उल्टी, दस्त, कब्ज, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, अल्सर, दिल का दौरा, स्ट्रोक, गुर्दे की समस्या और यकृत की क्षति शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, सीने में दर्द, सांस लेने में कठिनाई, या चेहरे, होंठ या गले में सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें और निर्देशित अवधि से अधिक समय तक उपयोग न करें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न पिएं। बिना डॉक्टर की सलाह के अन्य दर्द निवारक दवाएं न लें। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको पेट अल्सर, हृदय, गुर्दे या यकृत की बीमारी है, तो डॉक्टर को बताएं। चक्कर आने पर वाहन न चलाएं। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 activa p 100 mg/500 mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of moderate to severe pain after surgery.","evidence":"Well-established"},{"condition":"Dental pain","description":"Effective for relief of pain following dental procedures or toothache.","evidence":"Well-established"},{"condition":"Osteoarthritis flare-up","description":"Provides symptomatic relief of pain and stiffness during acute exacerbations of osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Used as an adjunct for short-term relief of pain and swelling in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Renal colic","description":"May be used off-label for pain relief in kidney stones, but other treatments are preferred.","evidence":"Limited"}]

Primary treatment for: Pain and inflammation

Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Musculoskeletal injuries, Post-operative pain, Dental pain

📋 Drug Information

Generic Name(s)Diclofenac + Paracetamol
Brand NameAt Sp Tablet
ManufacturerZydus Healthcare Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine with food or milk to minimize gastrointestinal irritation.
2
Use the lowest effective dose for the shortest duration, especially in elderly patients.
3
Avoid prescribing this combination to patients with a history of peptic ulcer or gastrointestinal bleeding.
4
Monitor kidney and liver function in patients requiring prolonged therapy.
5
Warn patients about the increased cardiovascular risk associated with diclofenac.
6
Advise patients to avoid alcohol and other NSAIDs while taking this medicine.
7
Consider alternative analgesics in patients with heart failure, kidney disease, or uncontrolled hypertension.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Dental pain
This medicine is effective for dental pain.
Likely Use
✅
Menstrual cramps
This medicine can relieve menstrual pain.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac is rapidly and completely absorbed from the gastrointestinal tract after oral administration. Paracetamol is also rapidly absorbed from the gastrointestinal tract. Food may delay the absorption of diclofenac but does not significantly reduce the extent of absorption.
DistributionDiclofenac is highly bound to plasma proteins and distributes widely into body tissues, including synovial fluid. Paracetamol distributes rapidly into most body tissues and fluids, with a volume of distribution of approximately 0.9 L/kg.
Protein BindingDiclofenac: greater than 99% bound to plasma proteins, primarily albumin. Paracetamol: approximately 10-25% bound to plasma proteins.
MetabolismDiclofenac is metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C9, to several metabolites, including 4'-hydroxydiclofenac. Paracetamol is metabolized in the liver primarily by glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione.
Half-LifeDiclofenac: approximately 1-2 hours. Paracetamol: approximately 2-3 hours.
ExcretionDiclofenac is excreted mainly in the urine (about 65%) and bile (about 35%) as metabolites. Paracetamol is excreted in the urine as glucuronide and sulfate conjugates, with less than 5% excreted unchanged.
BioavailabilityDiclofenac: approximately 50-60% due to first-pass metabolism. Paracetamol: approximately 80-90%.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimeDiclofenac: 1-2 hours. Paracetamol: 0.5-1 hour.
Duration of ActionPain relief lasts approximately 4 to 6 hours, but this can vary depending on the individual and the severity of pain.

How It Works

This medicine combines two active ingredients with different mechanisms of action. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased production of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol (acetaminophen) acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and may also modulate pain perception through effects on serotonin pathways. The combination provides additive analgesic effects, with Diclofenac targeting peripheral inflammation and Paracetamol enhancing central pain relief.

Mechanism Steps

1
Inhibition of cyclooxygenase enzymes: Diclofenac binds to and inhibits the COX-1 and COX-2 enzymes, blocking the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: This leads to decreased production of prostaglandins, prostacyclin, and thromboxane, which are key mediators of inflammation, pain, and fever.
3
Central analgesic action of paracetamol: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis and modulate pain pathways, possibly involving serotonin and cannabinoid receptors.
4
Additive analgesic effect: The combination of peripheral anti-inflammatory action from diclofenac and central analgesic action from paracetamol results in enhanced pain relief.

💡 How to Take activa p 100 mg/500 mg tablet

Strength: Tablet containing Diclofenac 100 mg and Paracetamol 500 mg.

1Take the tablet with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Follow your doctor's prescribed schedule.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally two to three times daily, as prescribed by your doctor. The maximum daily dose should not exceed 3 tablets in 24 hours. This medicine should be taken with food or milk to reduce stomach upset. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate or exceed the prescribed dose. Use for the shortest duration necessary.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Consult your doctor for appropriate dosing.
Renal ImpairmentUse with caution in patients with kidney impairment. Dose reduction or avoidance may be necessary. Consult your doctor for appropriate dosing based on kidney function.
Hepatic ImpairmentUse with caution in patients with liver impairment. Dose reduction or avoidance may be necessary. Consult your doctor for appropriate dosing based on liver function.
Maximum Daily DoseThe maximum daily dose is 3 tablets (300 mg diclofenac and 1500 mg paracetamol) in 24 hours. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and stomach bleeding.
Caffeine
Limit
May increase stomach irritation.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of activa p 100 mg/500 mg tablet

✅ Common Side Effects

Stomach pain or heartburn (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Nausea (Common (5-10%))
Take with food. If vomiting occurs, contact your doctor.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if severe or persistent.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Diarrhea or constipation (Common (5-10%))
Stay hydrated. Consult doctor if severe or persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding or ulcer (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Heart attack or stroke (Rare (<0.1%))
Seek emergency care if you experience chest pain, shortness of breath, weakness on one side, or difficulty speaking.
Kidney failure (Rare (<0.1%))
Contact your doctor if you notice decreased urine output, swelling in legs, or sudden weight gain.
Liver damage (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or persistent nausea to your doctor immediately.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you experience swelling of face, lips, or throat, difficulty breathing, or severe rash.

⚠️ Rare Side Effects

Aseptic meningitis
Seek immediate medical attention if you experience severe headache, stiff neck, fever, and sensitivity to light.
Pancreatitis
Seek immediate care if you have severe upper abdominal pain that radiates to your back, with nausea and vomiting.
Stevens-Johnson syndrome
Seek emergency care if you develop a painful rash with blisters, peeling skin, or sores in the mouth or eyes.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Methotrexate Major
Lithium Major
ACE inhibitors Major
Diuretics Moderate
Corticosteroids Moderate
SSRIs Moderate
Cyclosporine Moderate
Digoxin Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Methotrexate
  • Lithium
  • ACE inhibitors and ARBs

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide, hydrochlorothiazide)
  • Corticosteroids
  • SSRIs
  • Cyclosporine
  • Digoxin

🍷 Alcohol Interaction

Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can potentiate liver damage, especially from paracetamol. It may also increase drowsiness and dizziness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney disease","Severe liver disease","Known hypersensitivity to diclofenac, paracetamol, or any component","Asthma, urticaria, or allergic reaction after taking aspirin or other NSAIDs","Third trimester of pregnancy","Coronary artery bypass graft (CABG) surgery perioperative period"]

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration.","Use with caution in elderly patients.","Monitor for signs of gastrointestinal bleeding.","May cause dizziness; avoid driving until you know how it affects you.","Consult doctor before use if you have heart, kidney, or liver disease.","Do not use with other NSAIDs or paracetamol-containing products."]

🤱 Lactation Safety

Diclofenac and paracetamol are excreted in breast milk in small amounts. Short-term use is generally considered compatible with breastfeeding, but consult your doctor before use. Avoid prolonged use.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage from paracetamol and gastrointestinal bleeding, kidney failure, and central nervous system effects from diclofenac. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours of ingestion, N-acetylcysteine for paracetamol toxicity, and supportive care. Monitor liver and kidney function, and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or use it for longer than advised. Take this medicine with food or a glass of milk to reduce the risk of stomach upset. Avoid drinking alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver damage. Do not take other pain relievers or cold medicines that contain paracetamol or NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, heart disease, kidney or liver problems, or asthma, inform your doctor before taking this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking this medicine. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of the reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use this medicine after the expiry date printed on the pack. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. Diclofenac may affect ovulation and is generally avoided during pregnancy, especially in the third trimester.

🏥 Post-Surgery Considerations

This medicine may be prescribed for post-operative pain. Follow your surgeon's instructions carefully. Inform your surgeon if you have a history of stomach ulcers or bleeding.

🦷 Dental Procedures

This medicine can be used for dental pain. Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.
🌞
Stay well hydrated.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are generally safe. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated
Avoid alcohol
Limit caffeine

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, allergic reactions, or if your pain does not improve within a few days. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney damage, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function is recommended. Use the lowest effective dose for the shortest duration. Consult your doctor if you need to use this medicine for more than a few days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Hot and cold compresses

May help reduce localized pain and inflammation.

Evidence: Limited
Acupuncture

Some evidence for chronic pain relief.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing intervals as advised by your doctor. Check local customs regulations regarding prescription medicines. Always carry enough supply for your trip and keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with post-operative pain after hernia repair
Was prescribed this medicine for short-term pain relief. He experienced good pain control but developed mild stomach upset. His doctor advised him to take it with food and antacid, which resolved the issue.
💡 Lesson: Taking this medicine with food and reporting side effects promptly helps manage tolerability.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor, as this can increase the risk of side effects.

Q: Can I take it during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. It is generally avoided in the third trimester.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for activa p 100 mg/500 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Activa P is safe to take for any type of pain without a prescription.
    Fact: This medicine contains a high dose of diclofenac and should only be taken as prescribed by a doctor for specific indications.
  • Myth: Taking more than the recommended dose will relieve pain faster.
    Fact: Taking more than the recommended dose increases the risk of serious side effects and does not provide faster relief.
  • Myth: Activa P can be taken on an empty stomach.
    Fact: It should be taken with food or milk to reduce the risk of stomach upset and bleeding.

🔄 Alternative Options

Generic Alternatives

  • Diclofenac 100 mg + Paracetamol 500 mg tablet

Brand Alternatives

  • Activa P 100 mg/500 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Activa P 100 mg/500 mg","composition":"Diclofenac 100 mg + Paracetamol 500 mg","strength":"100 mg + 500 mg","dosage_form":"Tablet","route":"Oral"},{"medicine":"Diclofenac 50 mg + Paracetamol 500 mg","composition":"Diclofenac 50 mg + Paracetamol 500 mg","strength":"50 mg + 500 mg","dosage_form":"Tablet","route":"Oral"},{"medicine":"Aceclofenac 100 mg + Paracetamol 500 mg","composition":"Aceclofenac 100 mg + Paracetamol 500 mg","strength":"100 mg + 500 mg","dosage_form":"Tablet","route":"Oral"}]

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