acotra 200 capsule - Itraconazole (200mg) medicine

Acotra 200 Capsule - Uses, Price, Side Effects

4.3 (16 reviews)
Itraconazole (200mg)
๐Ÿญ Ventus Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is acotra 200 capsule used for?

Acotra 200 Capsule contains Itraconazole 200mg, an antifungal medication used to treat fungal infections like aspergillosis, blastomycosis, and onychomycosis. It works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, thereby killing the fungi.

  • Generic Name: Itraconazole
  • Manufacturer: Ventus Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š acotra 200 capsule Uses & Benefits

Onychomycosis, dermatophytosis, candidiasis, histoplasmosis, blastomycosis, aspergillosis.

Off-label uses: Coccidioidomycosis, sporotrichosis, chromoblastomycosis, prophylaxis in immunocompromised patients.

๐Ÿ“‹ Drug Information

Generic Name(s)Itraconazole
Brand NameAlcros 100 Capsule
ManufacturerVentus Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL
Action ClassFungal ergosterol synthesis inhibitor
Route of AdministrationOral
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; absorption is enhanced when taken with food.
DistributionWidely distributed in body tissues, including skin, nails, and adipose tissue.
Protein Binding99.8% bound to plasma proteins, primarily albumin.
MetabolismExtensively metabolized in the liver via CYP3A4 to active metabolite hydroxyitraconazole.
Half-Life21-25 hours (itraconazole); 12-15 hours (hydroxyitraconazole)
ExcretionPrimarily excreted in feces (40%) and urine (35%) as metabolites.
BioavailabilityApproximately 55% (fasting); increased to 100% with food.
Onset of Action1-2 weeks for therapeutic effect in fungal infections.
Peak Plasma Time4-6 hours after oral administration.
Duration of ActionUp to 2-3 weeks after discontinuation due to tissue accumulation.

How It Works

Inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane.

Mechanism Steps

1Itraconazole enters fungal cell via diffusion.
2Binds to heme iron of fungal CYP450 14ฮฑ-demethylase.
3Inhibits conversion of lanosterol to ergosterol.

๐Ÿ’ก How to Take acotra 200 capsule

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of acotra 200 capsule

โœ… Common Side Effects

  • Nausea
  • Abdominal pain
  • Diarrhea
  • Headache
  • Dizziness
  • Rash

๐Ÿšจ Serious Side Effects

  • Hepatotoxicity
  • Congestive heart failure
  • QT prolongation
  • Torsades de pointes
  • Stevens-Johnson syndrome

โš ๏ธ Rare Side Effects

  • Peripheral neuropathy
  • Adrenal suppression
  • Hypokalemia
  • Gynecomastia

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Cisapride Major Risk of cardiac arrhythmias
Midazolam Major Prolonged sedation
Cyclosporine Moderate Increased cyclosporine levels
Digoxin Moderate Increased digoxin toxicity

๐Ÿšจ Major Interactions

  • CYP3A4 substrates (e.g., midazolam, triazolam)
  • HMG-CoA reductase inhibitors (e.g., simvastatin, lovastatin)
  • Ergot alkaloids
  • Cisapride
  • Pimozide
  • Quinidine
  • Dofetilide
  • Lovastatin
  • Simvastatin

โšก Moderate Interactions

  • Warfarin
  • Oral hypoglycemics
  • Calcium channel blockers
  • Digoxin
  • Cyclosporine
  • Tacrolimus
  • Sirolimus
  • Carbamazepine
  • Phenytoin
  • Rifampin
  • Isoniazid
  • Antacids
  • H2 blockers
  • Proton pump inhibitors

โ„น๏ธ Minor Interactions

  • Corticosteroids
  • Benzodiazepines (e.g., alprazolam)
  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

Absorption increased with acidic beverages (e.g., cola) and food; avoid grapefruit juice.

๐Ÿท Alcohol Interaction

Avoid alcohol due to potential hepatotoxicity.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Low
Heart
Low
Pregnancy
Category C

๐Ÿšซ Contraindications

Hypersensitivity to itraconazole or excipients; concomitant use with CYP3A4 substrates with narrow therapeutic index; ventricular dysfunction; pregnancy (category C).

๐Ÿ“Š Monitoring Parameters

Liver function tests (ALT, AST), serum potassium, ECG (QT interval), therapeutic drug monitoring if needed.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution.

๐Ÿ’Š Overdose Management

Supportive care; no specific antidote; gastric lavage if recent; monitor liver function and ECG.

โฐ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for acotra 200 capsule

View All

Alternative brands with exact same active ingredient (Itraconazole (200mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

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