Acnim Tablet - Uses, Price, Side Effects
What is acnim tablet used for?
Acnim Tablet is a combination medicine containing Nimesulide (100mg) and Paracetamol (500mg). It is used for relief of pain and fever in conditions like headache, toothache, muscle pain, and menstrual cramps. Nimesulide works by reducing inflammation, while Paracetamol acts on the brain to lower fever and pain.
- Generic Name: Nimesulide + Paracetamol
- Manufacturer: Orphic Pharma (India) Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ acnim tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Nimesulide + Paracetamol |
| Brand Name | AP 100mg/325mg Tablet |
| Manufacturer | Orphic Pharma (India) Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Nimesulide selectively inhibits COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in the CNS, reducing pain and fever
Mechanism Steps
๐ก How to Take acnim tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of acnim tablet
โ Common Side Effects
- Nausea
- Vomiting
- Dizziness
- Somnolence
- Diarrhea
๐จ Serious Side Effects
- Hepatotoxicity
- Gastrointestinal bleeding
- Stevens-Johnson syndrome
- Renal failure
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Anaphylaxis
- Pancreatitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Moderate | Increased risk of gastrointestinal bleeding |
| Methotrexate | Major | Increased methotrexate toxicity |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Lithium
- Aspirin
- Other NSAIDs
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid alcohol
๐ท Alcohol Interaction
Increased risk of hepatotoxicity and gastrointestinal bleeding
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active peptic ulcer, severe hepatic/renal impairment, third trimester pregnancy, lactation, children <12 years (Nimesulide)
๐ Monitoring Parameters
Liver function, renal function, blood pressure, signs of bleeding
๐คฑ Lactation Safety
Paracetamol is safe; Nimesulide is contraindicated
๐ Overdose Management
Activated charcoal, N-acetylcysteine for paracetamol overdose; supportive care
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose