acloseep th 100mg/4mg tablet - Aceclofenac (100mg) + Thiocolchicoside (4mg) medicine

Aldigesic TH 100mg/4mg Tablet: Complete Medicine Guide

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🏭 Seepi Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. This medicine is not recommended during pregnancy, especially in the third trimester, due to risks to the fetus. Consult your doctor for safer alternatives. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute musculoskeletal pain.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is acloseep th 100mg/4mg tablet used for?

This medicine is a combination of aceclofenac (an NSAID) and thiocolchicoside (a muscle relaxant) used for short-term relief of acute musculoskeletal pain and muscle spasm. It is taken orally with food, usually two to three times a day, and should not be used for long periods without medical supervision.

  • Generic Name: Aceclofenac + Thiocolchicoside
  • Manufacturer: Seepi Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 acloseep th 100mg/4mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा एसिटोक्लोफेनाक और थायोकोल्चिकोसाइड का संयोजन है, जिसका उपयोग मांसपेशियों और जोड़ों के दर्द और ऐंठन के अल्पकालिक उपचार के लिए किया जाता है। यह दर्द, सूजन और मांसपेशियों की ऐंठन को कम करने में मदद करती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर की सलाह के बिना लंबे समय तक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, गुर्दे या यकृत की समस्या, और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, त्वचा या आंखों का पीलापन, या पेशाब में कमी दिखे, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन के साथ। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और यकृत की समस्या का खतरा बढ़ सकता है। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको गुर्दे, यकृत या हृदय की बीमारी है, तो डॉक्टर को बताएं। इस दवा को बच्चों की पहुंच से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 acloseep th 100mg/4mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Provides short-term relief of pain and inflammation in muscles, ligaments, and tendons.","evidence":"Well-established"},{"condition":"Low back pain with muscle spasm","description":"Helps reduce pain and relaxes painful muscle spasms in the lower back.","evidence":"Well-established"},{"condition":"Neck pain (cervical spondylosis)","description":"Relieves pain and stiffness associated with cervical muscle spasm.","evidence":"Moderate"},{"condition":"Post-traumatic pain","description":"Used after sprains, strains, and soft tissue injuries to reduce pain and swelling.","evidence":"Moderate"},{"condition":"Post-operative pain","description":"Sometimes prescribed for short-term pain relief after minor surgeries.","evidence":"Limited"}]

Off-label uses: [{"condition":"Tension headache","description":"Occasionally used off-label for tension-type headaches with muscle spasm.","evidence":"Limited"},{"condition":"Fibromyalgia","description":"Not a standard treatment, but sometimes used for short-term symptom relief.","evidence":"Limited"}]

Primary treatment for: Acute musculoskeletal pain with muscle spasm

Also treats: Low back pain, Neck pain, Osteoarthritis, Post-traumatic pain, Post-operative pain

📋 Drug Information

Generic Name(s)Aceclofenac + Thiocolchicoside
Brand NameAldigesic TH 100mg/4mg Tablet
ManufacturerSeepi Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID + Muscle Relaxant
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place. Protect from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine with food to minimize gastrointestinal irritation.
2
Limit the duration of therapy to the shortest time necessary to control symptoms.
3
Assess renal and hepatic function before starting and during prolonged therapy.
4
Avoid concomitant use with other NSAIDs or anticoagulants.
5
Warn patients about drowsiness and advise against driving if affected.
6
Consider gastroprotective agents in patients at high risk of ulcers.
7
Monitor for signs of bleeding, especially in elderly patients.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
✅
Muscle spasm
Thiocolchicoside component helps relieve muscle spasm.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Headache
Not typically used for primary headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAceclofenac is rapidly absorbed after oral administration. Thiocolchicoside is also absorbed from the gastrointestinal tract. Food may slightly delay absorption but does not significantly reduce the extent of absorption.
DistributionAceclofenac is highly bound to plasma proteins and distributes into synovial fluid and inflamed tissues. Thiocolchicoside distributes into tissues, including the central nervous system, where it exerts its muscle relaxant effects.
Protein BindingAceclofenac is approximately 99% bound to plasma proteins, primarily albumin. Thiocolchicoside is about 80% bound to plasma proteins.
MetabolismAceclofenac is metabolized in the liver, mainly by cytochrome P450 enzymes, to inactive metabolites. Thiocolchicoside is metabolized in the liver by deacetylation and glucuronidation.
Half-LifeThe elimination half-life of aceclofenac is approximately 4 hours. The elimination half-life of thiocolchicoside is approximately 4 to 6 hours.
ExcretionAceclofenac and its metabolites are excreted primarily in urine and to a lesser extent in feces. Thiocolchicoside and its metabolites are excreted mainly in urine.
BioavailabilityThe oral bioavailability of aceclofenac is approximately 80-100%. The oral bioavailability of thiocolchicoside is about 25-30% due to first-pass metabolism.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration. Muscle relaxant effects may take a few hours to become noticeable.
Peak Plasma TimeAceclofenac reaches peak plasma concentration in about 1.5 to 2 hours. Thiocolchicoside reaches peak plasma concentration in about 1 to 2 hours.
Duration of ActionThe analgesic and anti-inflammatory effects of aceclofenac last about 8 to 12 hours. The muscle relaxant effect of thiocolchicoside lasts about 6 to 8 hours. Therefore, this medicine is usually taken two to three times a day.

How It Works

This medicine combines two active ingredients with complementary actions. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the production of prostaglandins that cause pain, inflammation, and fever. Thiocolchicoside is a centrally acting muscle relaxant that acts on GABA-A receptors and glycine receptors in the spinal cord and brainstem, reducing excessive muscle tone and spasms. Together, they address both the inflammatory component and the muscle spasm component of musculoskeletal pain.

Mechanism Steps

1
COX enzyme inhibition by aceclofenac: Aceclofenac inhibits cyclooxygenase enzymes, especially COX-2, reducing prostaglandin production at the site of inflammation.
2
Reduced pain and inflammation: Lower prostaglandin levels decrease sensitization of pain receptors and reduce swelling and inflammation.
3
GABA-A receptor activation by thiocolchicoside: Thiocolchicoside binds to GABA-A receptors in the central nervous system, enhancing inhibitory signals.
4
Muscle relaxation: Enhanced inhibition reduces excessive motor neuron activity, leading to relaxation of skeletal muscle spasms.
5
Combined symptomatic relief: The anti-inflammatory and muscle relaxant effects work together to relieve pain and improve mobility.

💡 How to Take acloseep th 100mg/4mg tablet

Strength: Each tablet contains aceclofenac 100 mg and thiocolchicoside 4 mg.

1Take this medicine orally with a full glass of water.
2Take it with or immediately after food to minimize stomach irritation.
3Swallow the tablet whole; do not crush, chew, or break it.
4Follow your doctor's prescribed dose and duration exactly.
5Do not take more than the recommended dose.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine abruptly without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally two to three times a day, preferably after meals. The exact dose and duration depend on the condition being treated, its severity, and your response to therapy. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney impairment, and drowsiness. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with mild to moderate kidney impairment. Dose reduction may be necessary. Avoid in severe kidney disease (eGFR <30 mL/min). Dose must be individualized by a qualified clinician based on renal function.
Hepatic ImpairmentUse with caution in patients with mild to moderate liver impairment. Dose reduction may be necessary. Avoid in severe liver disease. Dose must be individualized by a qualified clinician based on hepatic function.
Maximum Daily DoseThe maximum recommended daily dose is one tablet three times a day (total 300 mg aceclofenac and 12 mg thiocolchicoside). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver problems.
Grapefruit juice
Avoid or limit
May increase drug levels by affecting liver enzymes.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of acloseep th 100mg/4mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food. If nausea persists, consult your doctor.
Stomach pain or heartburn (Common (5-10%))
Take with food or antacids. Avoid spicy foods. Consult doctor if severe.
Headache (Common (5-10%))
Usually resolves on its own. Stay hydrated. Consult doctor if persistent.
Dizziness or drowsiness (Common (5-10%))
Avoid driving or operating machinery. Consult doctor if severe.
Diarrhea or constipation (Common (5-10%))
Maintain hydration. Consult doctor if persistent.

🚨 Serious Side Effects

Gastrointestinal bleeding or ulcer (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency care if you experience swelling of face, lips, throat, difficulty breathing, or severe rash.
Kidney impairment (Rare (<0.1%))
Report decreased urine output, swelling in legs, or fatigue to your doctor immediately.
Liver toxicity (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor.
Blood disorders (e.g., agranulocytosis, thrombocytopenia) (Very rare (<0.01%))
Report unusual bleeding, bruising, fever, or sore throat to your doctor immediately.

⚠️ Rare Side Effects

Photosensitivity reaction
Avoid sun exposure and use sunscreen. Consult doctor if rash develops.
Mood changes or confusion
Consult your doctor if you experience unusual mood changes.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Corticosteroids Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
SSRIs Moderate
Oral hypoglycemics Moderate
Phenytoin Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin and other anticoagulants
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Corticosteroids
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • Antihypertensives (ACE inhibitors, ARBs, diuretics)
  • SSRIs
  • Oral hypoglycemics
  • Phenytoin

🍷 Alcohol Interaction

Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity when combined with aceclofenac. It may also enhance the drowsiness caused by thiocolchicoside.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Active or history of peptic ulcer or gastrointestinal bleeding","Severe kidney disease (eGFR

⚠️ Warnings & Precautions

["Take with food to reduce stomach irritation.","Avoid alcohol consumption.","Do not drive or operate machinery if you feel drowsy.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you have a history of kidney, liver, or heart disease.","Do not use for longer than prescribed without medical supervision.","Avoid concomitant use with other NSAIDs.","Monitor for signs of bleeding or bruising."]

🤱 Lactation Safety

Not established from the available information. Aceclofenac and thiocolchicoside may pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of this medicine may cause severe nausea, vomiting, abdominal pain, drowsiness, and gastrointestinal bleeding. In case of suspected overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if taken recently. Monitor vital signs, kidney and liver function, and manage complications accordingly.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor, usually with food to minimize stomach upset. Do not take more than the recommended dose or use it for longer than advised. Avoid alcohol while taking this medicine because it can increase the risk of stomach bleeding and liver problems. Inform your doctor if you have a history of ulcers, kidney or liver disease, heart problems, asthma, or bleeding disorders. Do not take other pain relievers or NSAIDs without consulting your doctor, as this can increase side effects. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Keep this medicine out of reach of children and store it in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events with NSAIDs. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely. Avoid in frail elderly with multiple comorbidities.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended for women planning pregnancy or those who are pregnant, especially in the third trimester, due to potential risks to the fetus. Consult your doctor for safer alternatives for pain relief.

🏥 Post-Surgery Considerations

This medicine may be prescribed for short-term post-operative pain relief. However, it should be used with caution after surgery due to the risk of bleeding and kidney problems. Follow your surgeon's instructions carefully.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop it temporarily before surgery.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Engage in regular low-impact exercises like swimming or walking.
😴
Practice good posture to prevent muscle strain.
💧
Include anti-inflammatory foods such as fruits, vegetables, and omega-3 rich fish in your diet.
🧘
Get adequate sleep to promote muscle recovery.
🌞
Avoid heavy lifting or sudden jerky movements during acute pain.

🏋️ Exercise Considerations

Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have muscle spasm or pain. Gentle stretching and low-impact activities may be beneficial, but consult your doctor or physiotherapist before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Stay well hydrated by drinking plenty of water.
Eat a balanced diet rich in fruits and vegetables.
Limit caffeine and alcohol consumption.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Most people can continue their daily activities with caution.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, or signs of kidney or liver problems. Do not stop abruptly without medical advice if you have been taking it for a prolonged period.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of kidney and liver function is recommended if prolonged use is necessary. It is not intended for long-term management of chronic pain without specialist supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve muscle strength and flexibility.

Evidence: Well-established
Hot or cold compresses

May help relieve muscle spasm and pain locally.

Evidence: Moderate
Acupuncture

Some evidence for short-term relief of musculoskeletal pain.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue taking the medicine at the same intervals as prescribed, but consult your doctor for specific advice. Check local customs regulations regarding prescription medicines before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 60-year-old man with acute low back pain and muscle spasm
Was prescribed this medicine for 5 days. He experienced relief from pain and spasm within 2 days. He was advised to avoid alcohol and driving due to drowsiness.
💡 Lesson: Short-term use with proper precautions can provide effective relief from acute musculoskeletal pain.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Pain relief typically begins within 30 to 60 minutes after taking this medicine. Muscle relaxant effects may take a few hours to become noticeable.

Q: Can I take this medicine on an empty stomach?

A: It is best to take this medicine with food to reduce the risk of stomach upset and ulcers.

Q: Is it safe to take this medicine with other pain relievers?

A: Do not take other NSAIDs or pain relievers without consulting your doctor, as it may increase the risk of side effects.

Q: Can I stop taking this medicine when I feel better?

A: Do not stop taking this medicine abruptly without consulting your doctor. Follow the prescribed duration.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for acloseep th 100mg/4mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: This medicine is intended for short-term use only. Long-term use increases the risk of kidney, liver, and gastrointestinal problems.
  • Myth: It is safe to take this medicine on an empty stomach.
    Fact: Taking this medicine with food is recommended to reduce stomach irritation and the risk of ulcers.
  • Myth: This medicine is safe during pregnancy.
    Fact: This medicine is not recommended during pregnancy, especially in the third trimester, due to potential risks to the fetus.

🔄 Alternative Options

Generic Alternatives

  • Aceclofenac 100 mg + Thiocolchicoside 4 mg tablet (generic)

Brand Alternatives

  • Aldigesic TH 100mg/4mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Aceclofenac 100 mg + Thiocolchicoside 4 mg","uses":"Acute musculoskeletal pain with spasm","notes":"Combination of NSAID and muscle relaxant."},{"medicine":"Aceclofenac 100 mg + Paracetamol 325 mg","composition":"Aceclofenac 100 mg + Paracetamol 325 mg","uses":"Pain and inflammation","notes":"No muscle relaxant component."},{"medicine":"Thiocolchicoside 4 mg","composition":"Thiocolchicoside 4 mg","uses":"Muscle spasm","notes":"No anti-inflammatory component."}]

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