Acetis P Tablet: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Persistent nausea or vomiting
If experiencing severe symptoms, call emergency services immediately.
What is aciz plus 100 mg/650 mg tablet used for?
This medicine is a combination of Aceclofenac 100 mg and Paracetamol 650 mg used for short-term relief of pain and inflammation in conditions like arthritis, musculoskeletal pain, and dental pain. It works by reducing prostaglandins that cause pain and fever. Take it with food to avoid stomach upset and do not exceed the prescribed dose.
- Generic Name: Aceclofenac + Paracetamol
- Manufacturer: Ritz Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 aciz plus 100 mg/650 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटोक्लोफेनैक 100 मिलीग्राम और पैरासिटामोल 650 मिलीग्राम का संयोजन है। इसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है, जैसे कि गठिया, मांसपेशियों में दर्द, दांत दर्द, और ऑपरेशन के बाद के दर्द में। यह दवा शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करके दर्द और बुखार को कम करती है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो। इसका सेवन डॉक्टर के परामर्श के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, जिगर की क्षति, गुर्दे की समस्या, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, उल्टी में खून, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव और जिगर की क्षति का खतरा बढ़ सकता है। यदि आपको पेट की बीमारी, गुर्दे या जिगर की बीमारी, दिल की बीमारी, या अस्थमा है, तो डॉक्टर को बताएं। इस दवा को लेने के दौरान वाहन चलाने या मशीनरी चलाने से बचें क्योंकि इससे चक्कर आ सकते हैं। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को डॉक्टर से परामर्श के बाद ही इसका सेवन करना चाहिए।
💊 aciz plus 100 mg/650 mg tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces pain and inflammation in rheumatoid arthritis as an adjunct to disease-modifying therapy.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate pain and stiffness associated with ankylosing spondylitis.","evidence":"Moderate"},{"condition":"Acute musculoskeletal pain","description":"Provides rapid relief from acute musculoskeletal pain such as sprains, strains, and low back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Effective for short-term management of dental pain, including post-extraction pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for the management of mild to moderate post-operative pain.","evidence":"Moderate"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Fever","description":"May be used off-label for fever reduction, though not a primary indication.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation associated with musculoskeletal conditions
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal pain, Dental pain, Post-operative pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Aceclofenac + Paracetamol |
| Brand Name | Aldigesic P |
| Manufacturer | Ritz Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Aceclofenac, an NSAID, inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol, although structurally related to NSAIDs, acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, leading to analgesia and antipyresis. The combination provides enhanced pain relief through both peripheral and central mechanisms.
Mechanism Steps
💡 How to Take aciz plus 100 mg/650 mg tablet
Strength: Aceclofenac 100 mg + Paracetamol 650 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times a day, preferably after meals. The maximum daily dose should not exceed three tablets in 24 hours. The exact dose and duration of treatment must be individualized by a qualified clinician based on the indication, severity of pain, age, weight, renal and hepatic function, and response to therapy. Do not self-medicate or exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more susceptible to the side effects of this medicine, especially gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration possible. Regular monitoring of kidney and liver function is recommended. Consult a doctor for appropriate dosing. |
| Renal Impairment | Use with caution in patients with mild to moderate kidney impairment. Dose reduction may be necessary. This medicine is contraindicated in severe kidney impairment (eGFR <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with mild to moderate liver impairment. Dose reduction and monitoring of liver function are recommended. This medicine is contraindicated in severe liver impairment. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose of this medicine is three tablets in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of aciz plus 100 mg/650 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antihypertensives | Moderate | |
| Zidovudine | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- ACE inhibitors and angiotensin receptor blockers
⚡ Moderate Interactions
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Lithium
- SSRIs
- Antihypertensives (e.g., beta-blockers, calcium channel blockers)
- Zidovudine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity, especially due to the Paracetamol component. It can also enhance the sedative effects of the medicine, leading to increased drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to Aceclofenac, Paracetamol, or any other NSAIDs","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure, ischemic heart disease, or cerebrovascular disease","Severe liver impairment or active liver disease","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Take with food to reduce gastrointestinal irritation.","Avoid alcohol and other NSAIDs during treatment.","Use with caution in elderly patients due to increased risk of side effects.","Monitor liver and kidney function during prolonged use.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not exceed the recommended dose or duration of treatment.","Consult your doctor if you have a history of gastrointestinal bleeding, heart disease, or kidney disease.","Not recommended during pregnancy, especially in the third trimester, and during breastfeeding without medical advice."]
🤱 Lactation Safety
Aceclofenac and Paracetamol are excreted in breast milk in small amounts. Paracetamol is generally considered safe during breastfeeding. Aceclofenac should be used with caution as there is limited data on its safety during lactation. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to Paracetamol toxicity, as well as gastrointestinal bleeding and kidney impairment from Aceclofenac. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. If you suspect an overdose, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for Paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce the risk of stomach irritation. Avoid alcohol while taking this medicine, as it can increase the risk of gastrointestinal bleeding and liver damage. Do not take other medications containing Paracetamol or NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma, inform your doctor before taking this medicine. This medicine may cause dizziness or drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Pregnant women, especially in the third trimester, and breastfeeding mothers should consult their doctor before using this medicine. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you experience any unusual symptoms or side effects, contact your healthcare provider immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Regular monitoring of kidney and liver function is recommended. Avoid concurrent use of other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like Aceclofenac may interfere with ovulation and are generally avoided during pregnancy, especially in the third trimester. Paracetamol is considered relatively safe but should be used at the lowest effective dose for the shortest duration.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain relief, but it should be used with caution due to the risk of bleeding and kidney impairment. Inform your surgeon and anesthesiologist about all medications you are taking. Do not take this medicine without your doctor's approval after surgery.
🦷 Dental Procedures
This medicine can be taken for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase the risk of bleeding. It is generally recommended to stop NSAIDs before major dental surgery, but consult your dentist or doctor for specific advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue with light to moderate exercise as tolerated. However, avoid high-impact activities that may worsen joint pain or cause injury. If you experience dizziness or drowsiness, avoid exercises that require balance or coordination. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture. Inform your employer if your work involves operating heavy machinery.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain persists beyond 7 days, if you experience any serious side effects, or if you develop new symptoms. Do not stop abruptly if you have been taking it for a long time without consulting your doctor, as this may cause rebound pain.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of liver and kidney function, blood counts, and blood pressure is recommended. It should be used at the lowest effective dose for the shortest duration possible. Consult your doctor if you need to use it for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: ModerateMay provide pain relief for some individuals with chronic pain.
Evidence: LimitedYoga, meditation, and relaxation techniques can help manage chronic pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If you are crossing time zones, adjust your dosing schedule accordingly, but do not take a double dose. Check the customs regulations of your destination country regarding prescription medicines. Always keep it in your carry-on luggage to avoid loss or exposure to extreme temperatures.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: It should only be taken daily for short periods as prescribed by your doctor. Long-term use requires monitoring of liver and kidney function.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Do not take other NSAIDs or Paracetamol-containing products without consulting your doctor, as this can increase the risk of side effects.
🤔 Common Patient Concerns
🔄 Substitutes for aciz plus 100 mg/650 mg tablet
View AllAlternative brands with exact same active ingredient:
-
stednac 650 100 mg/650 mg tabletStedman Pharmaceuticals Pvt Ltd ₹25.67 23% CHEAPER
-
unidic a 100 mg/650 mg tabletUnimarck Healthcare Ltd ₹27.19 18.5% CHEAPER
-
acebey p 100 mg/650 mg tabletAbbey Health Care Pvt Ltd ₹28.35 15% CHEAPER
-
cefen p 100mg/650mg tabletCE-Biotec Pvt Ltd ₹29.50 11.5% CHEAPER
-
beap 100 mg/650 mg tabletBiological E Ltd ₹31.78 4.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure arthritis.
Fact: This medicine provides symptomatic relief but does not cure arthritis. It should be used as part of a comprehensive treatment plan. - Myth: It is safe to take this medicine for a long time without monitoring.
Fact: Long-term use requires regular monitoring of liver and kidney function due to potential side effects. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of gastrointestinal bleeding and liver damage. Avoid alcohol while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac 100 mg + Paracetamol 650 mg tablet (generic)
Brand Alternatives
- Acenac-P
- Aceclo-P
- Zerodol-P
- Hifenac-P
- Aceproxyvon-P