Acicol O Syrup: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Vomiting blood or material that looks like coffee grounds
- Black, tarry stools or blood in the stool
- Severe or persistent abdominal pain that does not settle
- Difficulty swallowing or food getting stuck in the throat
- Unexplained weight loss along with acid symptoms
- Chest pain spreading to the arm, jaw, or back, or shortness of breath
- Swelling of the face, lips, or throat, or difficulty breathing
- Confusion, muscle weakness, or irregular heartbeat after prolonged use
If experiencing severe symptoms, call emergency services immediately.
What is acicol o syrup used for?
This medicine is an oral antacid and antiflatulent syrup containing magaldrate and simethicone. It neutralises stomach acid and helps relieve trapped gas, providing short-term relief from heartburn, indigestion, and bloating. It should be taken as advised by a doctor and is not meant for long-term self-treatment.
- Generic Name: Magaldrate + Simethicone
- Manufacturer: Positive Medicare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acicol o syrup के बारे में (Hindi Summary)
उपयोग: यह दवा मैगल्ड्रेट और सिमेथिकोन का मिश्रण है, जो पेट की एसिडिटी, सीने में जलन, खट्टी डकार, गैस और पेट फूलने की समस्या में राहत देती है। मैगल्ड्रेट पेट के अतिरिक्त एसिड को बेअसर करता है, जबकि सिमेथिकोन आंतों में फंसी गैस के बुलबुले को छोटा करके बाहर निकालने में मदद करता है। यह दवा खाने के बाद या रात को सोने से पहले डॉक्टर की सलाह के अनुसार ली जाती है। इसे दो हफ्तों से ज्यादा बिना डॉक्टर की सलाह के नहीं लेना चाहिए। किडनी की गंभीर बीमारी, पेट में रुकावट या दवा से एलर्जी होने पर इसका इस्तेमाल न करें।
साइड इफेक्ट्स: इस दवा को सही मात्रा में लेने पर ज्यादातर लोगों को कोई परेशानी नहीं होती। कुछ लोगों को दस्त, कब्ज, जी मिचलाना, पेट में हल्की ऐंठन या मुँह में चॉक जैसा स्वाद महसूस हो सकता है। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। लंबे समय तक ज्यादा मात्रा में लेने से शरीर में मैग्नीशियम और एल्युमिनियम की मात्रा बढ़ सकती है, खासकर किडनी की बीमारी वाले लोगों में। अगर साँस लेने में तकलीफ, चेहरे या गले में सूजन, बहुत ज्यादा कमजोरी, भ्रम या दिल की धड़कन अनियमित हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह या लेबल पर लिखी मात्रा के अनुसार ही लें। हर बार लेने से पहले बोतल को अच्छी तरह हिलाएँ, क्योंकि दवा बैठ जाती है। दवा मापने के लिए दी गई चम्मच या कप का ही इस्तेमाल करें, घर की चम्मच से न मापें। बिना डॉक्टर की सलाह के दो हफ्तों से ज्यादा इसका सेवन न करें। किडनी की बीमारी, दिल की बीमारी या मैग्नीशियम कम लेने की सलाह वाले मरीज डॉक्टर से पूछकर ही लें। इस दवा और दूसरी मुँह से ली जाने वाली दवाओं के बीच कम से कम दो घंटे का अंतर रखें। शराब और तला-भुना खाना कम करें। अगर दो हफ्ते में आराम न मिले, काला मल आए, खून की उल्टी हो, वजन अचानक कम हो या निगलने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
💊 acicol o syrup Uses & Benefits
[{"condition":"Heartburn and acid indigestion","description":"This medicine neutralises excess gastric acid and provides rapid relief from burning discomfort behind the breastbone and in the upper abdomen.","evidence":"Well-established"},{"condition":"Gastro-oesophageal reflux symptoms","description":"It reduces acid exposure in the lower oesophagus and eases regurgitation and sour taste associated with reflux episodes.","evidence":"Well-established"},{"condition":"Functional dyspepsia with bloating","description":"The combination of magaldrate and simethicone helps relieve upper abdominal fullness, early satiety, and gas-related discomfort.","evidence":"Moderate"},{"condition":"Flatulence and abdominal distension","description":"Simethicone in this medicine helps coalesce trapped gas bubbles so they can pass more easily through the digestive tract.","evidence":"Moderate"},{"condition":"Gastritis-related discomfort","description":"It provides symptomatic relief of burning and gnawing stomach pain linked to acid irritation of the gastric lining.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prevention of medication-related gastric irritation","description":"Sometimes used short-term to reduce stomach upset caused by certain pain relievers or other oral medicines, but this should be guided by a clinician.","evidence":"Limited"},{"condition":"Biliary reflux symptoms","description":"Occasionally used for symptomatic relief of bile-related stomach discomfort, although evidence is not strong.","evidence":"Limited"}]
Primary treatment for: Acid-related gastrointestinal disorders with bloating
Also treats: Gastro-oesophageal reflux disease, Functional dyspepsia, Gastritis, Flatulence and abdominal distension
📋 Drug Information
| Generic Name(s) | Magaldrate + Simethicone |
| Brand Name | Aciloc-S Suspension Sugar Free |
| Manufacturer | Positive Medicare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antacid + Antiflatulent |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature, between 15°C and 30°C, in a dry place away from direct sunlight and heat. Keep the bottle tightly closed when not in use. Do not freeze the syrup. Keep it out of the reach of children and pets. |
| Shelf Life | The shelf life is usually 24 months from the date of manufacture when stored as directed. Always check the expiry date printed on the bottle and do not use the medicine after that date. Once opened, use the syrup within the period recommended on the label or by the pharmacist. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Magaldrate is a complex of magnesium and aluminium hydroxides that reacts with hydrochloric acid in the stomach to form water and neutral salts, thereby raising gastric pH and reducing acid irritation. It also adsorbs pepsin and bile acids, which lowers the digestive irritation of refluxed contents. Simethicone is a silicone-based surfactant that reduces the surface tension of gas bubbles in the gastrointestinal tract, causing small bubbles to merge into larger ones that are easier to expel by belching or passing flatus. Together, these actions relieve both acid-related burning and gas-related bloating.
Mechanism Steps
💡 How to Take acicol o syrup
Strength: This medicine is an oral syrup containing magaldrate 540 mg and simethicone 50 mg per 5 mL or per stated unit volume, as per the product label. It is an immediate-release liquid formulation.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one to two teaspoonfuls or the volume advised by your doctor, taken after meals and at bedtime, or as needed for symptoms. The exact dose and frequency depend on the severity of your symptoms, your age, your kidney function, and other medicines you are taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the maximum daily dose printed on the label. Shake the bottle well before measuring each dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine should only be given to children under the supervision of a qualified doctor, who will decide the appropriate dose based on the child's age, weight, and symptoms. |
| Elderly Dosage | Elderly patients may be more sensitive to the constipating and electrolyte effects of this medicine. The doctor may recommend a lower dose or a shorter duration of treatment. Kidney function should be checked before long-term use, and the medicine should be used only under medical supervision in patients above 65 years of age. |
| Renal Impairment | Patients with mild kidney impairment may use this medicine short-term under medical supervision, but those with moderate to severe kidney impairment should avoid it because magnesium and aluminium can accumulate. If use is unavoidable, the doctor will prescribe the lowest effective dose for the shortest possible time and monitor kidney function and electrolyte levels closely. |
| Hepatic Impairment | No specific dose adjustment is usually required for liver disease because this medicine is not significantly metabolised by the liver. However, patients with severe liver disease should use it only under medical advice, as their overall condition and other medicines may affect safe use. |
| Maximum Daily Dose | The maximum daily dose depends on the product label and the doctor's advice. In general, adults should not exceed the dose recommended on the package or by the clinician. Exceeding the maximum daily dose can increase the risk of diarrhoea, constipation, and electrolyte imbalance. Always follow the prescribed schedule and do not self-increase the dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acicol o syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Tetracycline | Major | |
| Fluoroquinolone antibiotics | Major | |
| Iron supplements | Major | |
| Levothyroxine | Major | |
| Beta-blockers | Moderate | |
| Corticosteroids | Moderate | |
| Phenytoin | Moderate | |
| Digoxin | Moderate | |
| Anticholinergic medicines | Minor | |
| Diuretics | Minor |
🚨 Major Interactions
- Tetracycline antibiotics
- Fluoroquinolone antibiotics
- Iron supplements
- Levothyroxine
⚡ Moderate Interactions
- Beta-blockers such as atenolol
- Corticosteroids
- Phenytoin
- Digoxin
🍷 Alcohol Interaction
Alcohol can irritate the stomach lining and increase acid production, which may worsen the symptoms this medicine is meant to relieve. Drinking alcohol while taking this medicine can also increase the risk of stomach upset and may reduce the overall benefit of treatment. It is best to avoid alcohol until your acid-related symptoms have settled and your doctor has advised that it is safe to resume.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to magaldrate, simethicone, or any other ingredient in this medicine","Severe kidney impairment or chronic kidney disease with electrolyte disturbance","Magnesium-restricted diet or conditions such as severe heart block or myasthenia gravis where magnesium is harmful","Suspected or confirmed bowel obstruction or severe constipation","Use in children below the age recommended by the doctor or product label"]
⚠️ Warnings & Precautions
["Do not use this medicine for more than two weeks without consulting a doctor, because persistent acid symptoms may indicate a more serious condition.","Use with caution in elderly patients, who are more prone to constipation and electrolyte problems.","Avoid taking this medicine at the same time as other oral medicines; separate doses by at least two hours.","Do not use this medicine to treat symptoms of a suspected heart attack, such as chest pain spreading to the arm or jaw.","Patients with kidney disease, heart failure, or dehydration should seek medical advice before using this medicine.","Keep the bottle tightly closed and shake well before each use to ensure even mixing of the ingredients.","Do not exceed the recommended dose even if symptoms feel severe, because overuse can cause serious side effects."]
🤱 Lactation Safety
Magaldrate and simethicone are not expected to pass into breast milk in significant amounts because they are poorly absorbed from the gastrointestinal tract. Short-term use at the recommended dose is generally considered compatible with breastfeeding. Breastfeeding mothers should still consult their doctor before using this medicine, particularly if they need it for more than a few days or if the baby has any health concerns.
💊 Overdose Management
Taking more than the recommended dose of this medicine can cause diarrhoea, constipation, abdominal pain, and, in severe cases, electrolyte imbalance. If you suspect an overdose, stop the medicine and contact your doctor or a poison control centre immediately. Treatment is supportive and may include fluids, electrolyte monitoring, and management of bowel symptoms. Do not try to treat an overdose at home with other medicines. If the person has severe symptoms such as confusion, muscle weakness, irregular heartbeat, or difficulty breathing, seek emergency medical care right away.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, provided the next scheduled dose is not due soon. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one, because this can increase the risk of side effects. If you miss doses often, speak to your doctor about adjusting your treatment plan.
Additional Safety Advice
Take this medicine exactly as directed by your doctor or as printed on the label. Shake the bottle well before each dose because the ingredients settle on standing. Measure the dose with the supplied spoon or cup rather than a household spoon. Do not take more than the recommended dose or use it for longer than advised without medical review. If you have kidney disease, heart failure, or a magnesium-restricted diet, speak to your doctor before using this medicine. Keep a gap of at least two hours between this medicine and other oral medicines, because antacids can reduce absorption of many drugs. Avoid alcohol and large fatty meals while you are being treated for acid symptoms. Do not use this medicine if the seal is broken or if the liquid looks discoloured. Store it out of reach of children. If symptoms persist beyond two weeks, or if you notice black stools, vomiting blood, unexplained weight loss, or difficulty swallowing, stop the medicine and consult a doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to develop constipation, electrolyte imbalance, and kidney-related problems with antacid syrups. They should use this medicine only under medical supervision, at the lowest effective dose, and for the shortest duration. Kidney function and electrolyte levels may need monitoring, especially if the medicine is used for more than a few days. Elderly patients should also be careful about interactions with their other regular medicines.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive or are in early pregnancy, do not start this medicine without consulting your doctor. Short-term use may be considered safe when advised, because the ingredients act locally and are poorly absorbed, but your doctor will weigh the benefits and risks. Treating underlying acid symptoms with lifestyle changes and safe medicines is important for your comfort and overall health during pregnancy planning.
🏥 Post-Surgery Considerations
After surgery, especially abdominal or gastrointestinal surgery, do not take this medicine unless your surgeon or doctor specifically advises it. Antacids can affect the absorption of post-operative medicines and may interfere with some tests. If you need acid relief after surgery, your doctor will recommend the safest option for your situation.
🦷 Dental Procedures
This medicine does not usually interfere with dental procedures. However, if you are taking other medicines for pain or infection around the time of dental work, keep a two-hour gap between this antacid and those medicines. Tell your dentist about all medicines you are taking, including this syrup, so that they can plan your treatment safely.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine does not usually restrict exercise, but vigorous activity immediately after a heavy meal can worsen reflux and bloating. Wait at least one to two hours after eating before doing intense exercise. If you feel dizzy, weak, or have muscle cramps during exercise while taking this medicine for a long time, stop and consult your doctor, as these could be signs of electrolyte imbalance.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine does not usually cause drowsiness or impair concentration, so most people can drive and work normally while taking it. However, if you feel dizzy, weak, or unwell, avoid driving or operating heavy machinery until you feel better. Because the syrup may cause mild stomach upset or changes in bowel habits, some people prefer to take it after meals at home or at work where a toilet is easily accessible. Keep your doses regular even on busy workdays to get consistent relief.
🛑 When to Stop This Medicine
Stop this medicine and consult a doctor if your symptoms do not improve within a few days, if they become worse, or if you develop red-flag symptoms such as black stools, vomiting blood, difficulty swallowing, or unexplained weight loss. Do not stop a prescribed course without speaking to your doctor, especially if you have kidney disease or are taking other medicines. If you have been using this medicine for more than two weeks, ask your doctor whether you still need it and whether another treatment would be safer.
📅 Long-Term Use Effects
Long-term use of this medicine without medical supervision can lead to constipation, diarrhoea, and changes in electrolyte levels, especially magnesium and aluminium accumulation in people with kidney disease. It can also mask serious conditions such as ulcers or stomach cancer, delaying diagnosis. If you need acid relief for more than two weeks, your doctor should review your symptoms, check your kidney function if needed, and consider whether a different class of medicine is more appropriate.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Smaller meals, avoiding trigger foods, weight loss, and not lying down after meals can reduce acid symptoms and may reduce the need for antacids.
Evidence: Well-establishedProton pump inhibitors or H2 blockers may be prescribed by a doctor for persistent or severe acid-related symptoms.
Evidence: Well-establishedYoga, breathing exercises, and adequate sleep can help reduce stress-related acid symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines and does not need to be stopped before vaccination. If you are due for a vaccine and are feeling unwell with severe acid symptoms, discuss with your doctor whether to postpone vaccination until you feel better.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not freeze the syrup
✅ DO
Keep the bottle tightly closed and upright
❌ DON'T
Do not leave the cap loose or store the bottle upside down
✅ DO
Keep away from direct sunlight and heat
❌ DON'T
Do not store near a stove, radiator, or in a hot car
✅ DO
Keep out of reach of children
❌ DON'T
Do not transfer the syrup to an unlabelled container
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original labelled bottle with the cap tightly closed. Keep a copy of your prescription or doctor's note, especially for international travel, because customs officials may ask about liquid medicines. Store it in your hand luggage if the cabin temperature is comfortable, and avoid leaving it in a hot car or in direct sunlight. If you are crossing time zones, continue your doses according to the schedule advised by your doctor rather than adjusting automatically. If you need to take other medicines during travel, remember to keep at least a two-hour gap from this antacid. Carry enough supply for the whole trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Relief from acid symptoms usually starts within a few minutes because the antacid acts directly in the stomach. The gas-relieving effect may take a little longer.
A: You should keep at least a two-hour gap between this medicine and other oral medicines, because antacids can reduce their absorption. Always tell your doctor and pharmacist about all medicines you take.
A: It is not meant for long-term self-treatment. Prolonged use can cause electrolyte problems and may hide a more serious condition. Use it only for the duration advised by your doctor.
A: If you remember soon after the missed dose, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular schedule. Do not double dose.
A: Short-term use may be acceptable when advised by a doctor, because the ingredients act locally and are poorly absorbed. However, pregnant women should not self-medicate and should consult their obstetrician first.
🤔 Common Patient Concerns
🔄 Substitutes for acicol o syrup
View AllAlternative brands with exact same active ingredient:
-
Swicain LiquidInd Swift Laboratories Ltd ₹19.92 74.7% CHEAPER
-
robcaine syrupPark Pharmaceuticals ₹40.80 48.2% CHEAPER
-
limacid suspensionAncalima Lifesciences Ltd ₹45.00 42.9% CHEAPER
-
wisfast a 540 mg/50 mg/10 mg liquidWisdom Pharma Pvt. Ltd ₹45.00 42.9% CHEAPER
-
gastronil oral suspensionVrinda Life ₹50.63 35.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure stomach ulcers permanently.
Fact: This medicine provides symptomatic relief by neutralising acid, but it does not cure ulcers. Ulcers need specific medical treatment and evaluation. - Myth: More medicine means faster relief.
Fact: Taking more than the recommended dose does not give faster relief and can cause diarrhoea, constipation, or electrolyte problems. - Myth: It is safe to take this medicine every day for months without review.
Fact: Long-term use without medical review can hide serious conditions and may cause side effects, especially in people with kidney disease. - Myth: This medicine can be taken at the same time as all other medicines.
Fact: Antacids can reduce the absorption of many medicines. Other oral medicines should be taken at least two hours apart.
🔄 Alternative Options
Generic Alternatives
- Magaldrate and simethicone oral suspension