Acebran BR Syrup: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe palpitations or irregular heartbeat
- Chest pain or tightness
- Difficulty breathing or worsening shortness of breath
- Swelling of the face, lips, tongue, or throat
- Severe dizziness or fainting
- Yellowing of the skin or eyes (jaundice)
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is acebrel plus syrup used for?
This medicine is a combination of terbutaline and acebrophylline used to treat asthma, chronic bronchitis, and COPD. It works by relaxing airway muscles and thinning mucus, making breathing easier. It is available as a syrup and is taken orally as prescribed by a doctor.
- Generic Name: Terbutaline + Acebrophylline
- Manufacturer: Cista Medicorp
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 acebrel plus syrup के बारे में (Hindi Summary)
उपयोग: यह दवा टर्ब्यूटलीन और एसीब्रोफिलीन का संयोजन है, जिसका उपयोग अस्थमा, क्रोनिक ब्रोंकाइटिस और सीओपीडी जैसी श्वसन संबंधी समस्याओं के इलाज में किया जाता है। यह वायुमार्ग की मांसपेशियों को आराम देकर और बलगम को पतला करके सांस लेने में आसानी प्रदान करती है। यह सिरप के रूप में उपलब्ध है और इसे मुंह से लिया जाता है। इसका उपयोग डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में हाथों का कांपना, घबराहट, सिरदर्द, मतली, उल्टी, पेट की गड़बड़ी और दिल की धड़कन बढ़ना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको तेज धड़कन, सीने में दर्द, सांस लेने में कठिनाई, चकत्ते, खुजली, या चेहरे, होंठ या गले में सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सही माप के लिए दवा के साथ दिया गया मापने वाला कप या चम्मच उपयोग करें। यदि आपको हृदय रोग, उच्च रक्तचाप, मधुमेह, थायरॉइड या दौरे की समस्या है, तो डॉक्टर को बताएं। गाड़ी चलाने या मशीनरी चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आपको कैसे प्रभावित करती है। शराब न पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 acebrel plus syrup Uses & Benefits
[{"condition":"Asthma","description":"Helps relieve bronchospasm and improves breathing in patients with asthma by relaxing airway muscles and reducing mucus thickness.","evidence":"Well-established"},{"condition":"Chronic bronchitis","description":"Used to manage chronic bronchitis by reducing mucus viscosity and easing cough, thereby improving airflow.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Provides symptomatic relief in COPD by bronchodilation and mucolysis, though it is not a first-line therapy.","evidence":"Moderate"},{"condition":"Bronchial asthma with excessive mucus","description":"Combines bronchodilation with mucolytic action to help clear mucus plugs and improve breathing.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Acute bronchitis","description":"Sometimes prescribed to relieve cough and mucus in acute bronchitis, though evidence is limited.","evidence":"Limited"},{"condition":"Smoker's cough","description":"May be used off-label to help loosen mucus and reduce cough in chronic smokers.","evidence":"Limited"}]
Primary treatment for: Asthma
Also treats: Chronic bronchitis, COPD, Bronchial asthma with excessive mucus
📋 Drug Information
| Generic Name(s) | Terbutaline + Acebrophylline |
| Brand Name | Acebran BR Syrup |
| Manufacturer | Cista Medicorp |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Bronchodilator + Mucolytic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep the bottle tightly closed. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Terbutaline is a selective beta-2 adrenergic receptor agonist that binds to beta-2 receptors on bronchial smooth muscle, leading to relaxation and bronchodilation. Acebrophylline is a xanthine derivative that inhibits phosphodiesterase enzymes, increasing cyclic AMP levels, which also promotes bronchodilation. Additionally, acebrophylline has mucolytic properties that reduce mucus viscosity and improve mucociliary clearance, making it easier to cough out mucus. Together, they work to open airways, reduce inflammation, and thin mucus, providing relief from breathing difficulties.
Mechanism Steps
💡 How to Take acebrel plus syrup
Strength: Each 5 ml of syrup contains Terbutaline 1.25 mg and Acebrophylline 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5-10 ml (1-2 teaspoons) two to three times a day, or as prescribed by your doctor. The dose may be adjusted based on your condition, response to treatment, and other medical factors. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially cardiovascular side effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult your doctor for appropriate dosing. |
| Hepatic Impairment | Dose adjustment may be required in patients with hepatic impairment. Consult your doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 30 ml (6 teaspoons) per day, but this may vary based on individual patient factors. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of acebrel plus syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Propranolol | Major | |
| MAOIs | Major | |
| Tricyclic antidepressants | Major | |
| Furosemide | Moderate | |
| Corticosteroids | Moderate | |
| Theophylline | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Beta-blockers (e.g., propranolol)
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Corticosteroids
- Xanthine derivatives (e.g., theophylline)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of cardiovascular side effects such as rapid heartbeat. It may also worsen the underlying respiratory condition. Consult your doctor about safe alcohol consumption.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to terbutaline, acebrophylline, or any component of the formulation","Severe cardiovascular disease (e.g., severe coronary insufficiency, arrhythmias)","Uncontrolled hypertension","Hyperthyroidism","Severe hepatic or renal impairment","Children under 12 years (unless specifically prescribed by a pediatrician)"]
⚠️ Warnings & Precautions
["Use with caution in patients with cardiovascular disorders, including coronary artery disease, arrhythmias, and hypertension.","May cause hypokalemia; monitor potassium levels, especially in patients on diuretics or corticosteroids.","May increase blood glucose levels; monitor in diabetic patients.","May cause tremors and nervousness; avoid driving or operating machinery until effects are known.","Not recommended for use during pregnancy unless clearly needed; consult your doctor.","Do not exceed the recommended dose; serious cardiac effects can occur.","Keep out of reach of children; store safely.","Inform your doctor if you have a history of seizures, thyroid disease, or diabetes."]
🤱 Lactation Safety
Terbutaline is excreted in breast milk and may cause adverse effects in the nursing infant. Acebrophylline: Not established from the available information. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine may cause severe tachycardia, palpitations, tremors, nausea, vomiting, hypokalemia, and hyperglycemia. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic, including monitoring of vital signs, electrolytes, and cardiac rhythm. There is no specific antidote. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or frequency. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring cup or spoon to measure the dose accurately; do not use a regular household spoon. Inform your doctor if you have a history of heart disease, high blood pressure, diabetes, thyroid problems, or seizures. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause dizziness or drowsiness. Do not drink alcohol while taking this medicine, as it can increase drowsiness and heart-related side effects. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children. Store it at room temperature, away from direct sunlight and moisture. Do not use this medicine after the expiry date printed on the pack. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the cardiovascular effects of terbutaline, such as increased heart rate and palpitations. They may also have reduced renal or hepatic function, requiring dose adjustments. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Terbutaline is classified as FDA pregnancy category C, and acebrophylline's safety is not established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. It may interact with anesthetic agents and affect heart rate and blood pressure. Your doctor may advise you to stop it temporarily before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth or increase heart rate during dental procedures. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience tremors or increased heart rate, which can affect your exercise tolerance. Start with light activities and gradually increase intensity as tolerated. Avoid strenuous exercise if you feel dizzy or short of breath. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or tremors, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause frequent urination or increased heart rate, which could impact your work. Discuss with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will determine if and when it is safe to stop the medicine, and may taper the dose gradually to avoid withdrawal effects.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, reduced effectiveness, and potential cardiovascular effects such as increased heart rate and palpitations. Regular monitoring of heart rate, blood pressure, and electrolyte levels is recommended. It is important to have periodic reviews with your doctor to assess the continued need for this medicine and to adjust the dose if necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Inhaled medications like salbutamol or ipratropium can provide rapid relief with fewer systemic side effects.
Evidence: Well-establishedFor long-term control of asthma, inhaled corticosteroids reduce airway inflammation.
Evidence: Well-establishedExercise and education programs can improve breathing and quality of life in chronic lung diseases.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with chronic respiratory diseases are advised to receive annual influenza and pneumococcal vaccines as per guidelines. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case you need to show it at customs or to a healthcare provider. Store it at room temperature and protect it from extreme heat or cold. If you are crossing time zones, adjust your dosing schedule gradually, but consult your doctor for specific advice. Always pack enough medicine for your entire trip, plus extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 minutes to 1 hour after oral administration, but the full effect may take a few days of regular use.
A: Yes, you can take this medicine with or without food. If it upsets your stomach, take it with a meal or snack.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Consult your doctor before taking this medicine during pregnancy. It should be used only if clearly needed.
A: Do not stop taking this medicine without consulting your doctor, as your symptoms may worsen. Your doctor will advise you on the appropriate duration of treatment.
🤔 Common Patient Concerns
🔄 Substitutes for acebrel plus syrup
View AllAlternative brands with exact same active ingredient:
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sputnix ab syrupTimon Tender Care Pharmaceuticals Private Limited ₹79.69 23.2% COSTLIER
-
pulmoril syrupZoic Lifesciences ₹89.06 37.7% COSTLIER
-
Terbis-A SyrupAlbris Healthcare And Biotech Pvt Ltd ₹91.88 42% COSTLIER
-
briovent syrupBrio Bliss Life Science Pvt Ltd ₹92.81 43.5% COSTLIER
-
muciday syrup honey raspberry sugar freeSeagull Pharmaceutical Pvt Ltd ₹92.81 43.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure asthma permanently.
Fact: This medicine helps control symptoms but does not cure asthma. It should be used as part of a comprehensive management plan. - Myth: It is safe to take extra doses if breathing difficulty worsens.
Fact: Taking extra doses can cause serious heart-related side effects. Always follow your doctor's prescription. - Myth: This medicine can be taken without a prescription.
Fact: This is a prescription medicine. It should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Terbutaline + Acebrophylline syrup (generic versions may be available)
Brand Alternatives
- Acebran BR Syrup