abline 500mg/75mg tablet - Uses, Price, Side Effects & Substitutes
What is abline 500mg/75mg tablet used for?
Axogurd-SR Tablet (Methylcobalamin + Pregabalin) is used to treat NEURO CNS. It contains Methylcobalamin (500mg) + Pregabalin (75mg), which Methylcobalamin: Coenzyme for myelin synthesis; Pregabalin: Binds to alpha2-delt. Always consult your doctor before use. Take as prescribed.
- Generic Name: Methylcobalamin + Pregabalin
- Manufacturer: Aanika Pharma
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ abline 500mg/75mg tablet Uses & Benefits
Diabetic neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury.
Off-label uses: Generalized anxiety disorder, social anxiety disorder, restless legs syndrome.
๐ Drug Information
| Generic Name(s) | Methylcobalamin + Pregabalin |
| Brand Name | Axogurd-SR Tablet |
| Manufacturer | Aanika Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Neurotropic vitamin + Gabapentinoid |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Methylcobalamin: Coenzyme for myelin synthesis; Pregabalin: Binds to alpha2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release.
Mechanism Steps
๐ก How to Take abline 500mg/75mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of abline 500mg/75mg tablet
โ Common Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Blurred vision
- Weight gain
- Constipation
๐จ Serious Side Effects
- Angioedema
- Hypersensitivity reactions
- Suicidal thoughts
- Rhabdomyolysis
- PR interval prolongation
โ ๏ธ Rare Side Effects
- Stevens-Johnson syndrome
- Hepatotoxicity
- Pancreatitis
- Blood dyscrasias
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CNS depressants | Major | Increased sedation and respiratory depression |
| Thalidomide | Major | Increased risk of peripheral neuropathy |
| ACE inhibitors | Major | Increased risk of angioedema |
| Oral hypoglycemics | Moderate | May enhance hypoglycemic effect |
| Antihypertensives | Moderate | Additive hypotensive effect |
| Antacids | Minor | Reduced absorption of pregabalin |
| H2 blockers | Minor | Possible reduced absorption of pregabalin |
๐จ Major Interactions
- Central nervous system depressants
- Thalidomide
- Angiotensin-converting enzyme inhibitors
โก Moderate Interactions
- Oral hypoglycemics
- Antihypertensives
โน๏ธ Minor Interactions
- Antacids
- H2 blockers
๐ฝ๏ธ Food Interactions
High-fat meal may delay absorption of pregabalin
๐ท Alcohol Interaction
Additive CNS depression; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; severe renal impairment (CrCl <30 mL/min) for pregabalin.
๐ Monitoring Parameters
Renal function, liver function, CBC, signs of hypersensitivity, CNS depression, suicidal ideation.
๐คฑ Lactation Safety
Pregabalin excreted in breast milk; caution advised.
๐ Overdose Management
Supportive care; activated charcoal if recent ingestion; hemodialysis may remove pregabalin.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.