Abicol MR 4mg/100mg/500mg Tablet - Uses, Price, Side Effects
What is abicol mr 4mg/100mg/500mg tablet used for?
Abicol MR 4mg/100mg/500mg Tablet is a combination medicine used for pain relief and muscle relaxation. It contains Thiocolchicoside, a muscle relaxant, and Aceclofenac, a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking pain signals and relaxing stiff muscles, providing relief from conditions like musculoskeletal pain, back pain, and joint pain.
- Generic Name: Thiocolchicoside + Aceclofenac
- Manufacturer: Alpic Biotech Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ abicol mr 4mg/100mg/500mg tablet Uses & Benefits
Acute musculoskeletal pain, muscle spasms, inflammatory conditions
Off-label uses: Not well established
๐ Drug Information
| Generic Name(s) | Thiocolchicoside + Aceclofenac |
| Brand Name | Anaflam TH 4 Tablet |
| Manufacturer | Alpic Biotech Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Muscle Relaxant + NSAID |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Thiocolchicoside: Acts on GABA-A and glycine receptors to produce muscle relaxation; Aceclofenac: Inhibits COX-1 and COX-2, reducing prostaglandin synthesis
Mechanism Steps
๐ก How to Take abicol mr 4mg/100mg/500mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of abicol mr 4mg/100mg/500mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Dizziness
- Somnolence
๐จ Serious Side Effects
- GI bleeding
- Peptic ulcer
- Renal failure
- Hepatotoxicity
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- Stevens-Johnson syndrome
- Seizures
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Lithium | Moderate | Increased lithium toxicity |
| Methotrexate | Major | Increased methotrexate toxicity |
| Aspirin | Moderate | Increased risk of gastrointestinal bleeding |
๐จ Major Interactions
- Warfarin
- Lithium
- Methotrexate
- Aspirin
- Other NSAIDs
โก Moderate Interactions
- ACE inhibitors
- Diuretics
- Anticoagulants
- Corticosteroids
โน๏ธ Minor Interactions
- Antacids
- Digoxin
- Phenytoin
๐ฝ๏ธ Food Interactions
May be taken with food to reduce GI upset
๐ท Alcohol Interaction
Increased risk of GI bleeding and hepatotoxicity
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, active peptic ulcer, severe renal/hepatic impairment, pregnancy (third trimester), lactation, children <16 years
๐ Monitoring Parameters
Liver function, renal function, blood pressure, GI symptoms
๐คฑ Lactation Safety
Not recommended; excreted in breast milk
๐ Overdose Management
Symptomatic and supportive; gastric lavage, activated charcoal
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose