abanor plus tablet - Uses, Price, Side Effects & Substitutes
What is abanor plus tablet used for?
Axogurd NT Tablet SR (Pregabalin + Nortriptyline) is used to treat NEURO CNS. It contains Pregabalin (75mg) + Nortriptyline (10mg), which Pregabalin binds to alpha-2-delta subunit of voltage-gated calcium channels, red. Always consult your doctor before use. Take as prescribed.
- Generic Name: Pregabalin + Nortriptyline
- Manufacturer: Elkos Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ abanor plus tablet Uses & Benefits
Neuropathic pain, fibromyalgia, generalized anxiety disorder, depression.
Off-label uses: Chronic pain, migraine prophylaxis, social anxiety disorder.
๐ Drug Information
| Generic Name(s) | Pregabalin + Nortriptyline |
| Brand Name | Axogurd NT Tablet SR |
| Manufacturer | Elkos Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Gabapentinoid + Tricyclic Antidepressant |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Pregabalin binds to alpha-2-delta subunit of voltage-gated calcium channels, reducing calcium influx and neurotransmitter release. Nortriptyline inhibits reuptake of norepinephrine and serotonin, increasing their synaptic concentrations.
Mechanism Steps
๐ก How to Take abanor plus tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of abanor plus tablet
โ Common Side Effects
- Dizziness
- Somnolence
- Dry mouth
- Constipation
- Blurred vision
- Weight gain
- Peripheral edema
๐จ Serious Side Effects
- Suicidal thoughts
- Serotonin syndrome
- Cardiac arrhythmias
- Seizures
- Angle-closure glaucoma
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Agranulocytosis
- Stevens-Johnson syndrome
- Rhabdomyolysis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CYP2D6 inhibitors | Major | Increased nortriptyline levels, toxicity |
| CNS depressants | Major | Additive sedation, respiratory depression |
| Anticholinergics | Moderate | Increased anticholinergic side effects |
| Antihypertensives | Moderate | Enhanced hypotensive effect |
| Grapefruit juice | Moderate | Increased nortriptyline levels |
๐จ Major Interactions
- MAOIs
- CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)
- CYP3A4 inhibitors (e.g., ketoconazole)
- Other CNS depressants (e.g., benzodiazepines, opioids)
โก Moderate Interactions
- Anticholinergics
- Antihypertensives
- Sympathomimetics
- Cimetidine
- Quinidine
โน๏ธ Minor Interactions
- Oral contraceptives
- Smoking (induces CYP1A2)
๐ฝ๏ธ Food Interactions
Pregabalin: No significant effect; Nortriptyline: Avoid grapefruit juice (CYP3A4 inhibition).
๐ท Alcohol Interaction
Avoid alcohol; increased CNS depression and risk of seizures.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, concurrent MAOI use, severe hepatic impairment, narrow-angle glaucoma, urinary retention.
๐ Monitoring Parameters
ECG, blood pressure, liver function, renal function, serum drug levels (nortriptyline), suicidal ideation.
๐คฑ Lactation Safety
Not recommended; both drugs excreted in breast milk.
๐ Overdose Management
Supportive care, activated charcoal, ECG monitoring, benzodiazepines for seizures, sodium bicarbonate for cardiac toxicity.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose.