A2D Capsule (Pregabalin 25mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, throat, or tongue, or difficulty breathing
- Thoughts of self-harm or suicide
- Slow, shallow breathing, especially if taking opioid pain medicines
- Unexplained muscle pain, weakness, or dark urine
- Severe dizziness or fainting
- New or worsening shortness of breath, swelling, or fatigue
- Rash with blisters or peeling skin
If experiencing severe symptoms, call emergency services immediately.
What is a2d capsule used for?
This medicine contains Pregabalin 25 mg, an anticonvulsant used to treat nerve pain, seizures, and fibromyalgia. It works by calming overactive nerves. Common side effects include dizziness and drowsiness. It is a prescription medicine and should only be taken under medical supervision.
- Generic Name: Pregabalin (25mg)
- Manufacturer: Bioceutics Inc
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 a2d capsule के बारे में (Hindi Summary)
उपयोग: यह दवा प्रेगाबालिन 25 मिलीग्राम कैप्सूल है, जिसका उपयोग नसों के दर्द, दौरे (मिर्गी), और फाइब्रोमायल्जिया के इलाज के लिए किया जाता है। यह दवा नसों में होने वाले असामान्य संकेतों को शांत करके दर्द और दौरों को कम करने में मदद करती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए। इसके सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, और वजन बढ़ना शामिल हैं। इसे अचानक बंद नहीं करना चाहिए, क्योंकि इससे withdrawal के लक्षण हो सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, नींद आना, धुंधली दृष्टि, मुँह सूखना, और वजन बढ़ना शामिल हैं। कुछ लोगों में हाथ-पैरों में सूजन भी हो सकती है। गंभीर दुष्प्रभावों में एलर्जी, आत्महत्या के विचार, और सांस लेने में कठिनाई शामिल हैं। अगर आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। शराब न पिएं। अगर आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं। अपनी सभी दवाओं के बारे में डॉक्टर को जानकारी दें।
💊 a2d capsule Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, shooting, or stabbing nerve pain in the feet and hands caused by diabetes.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"It reduces persistent nerve pain that can remain after a shingles infection.","evidence":"Well-established"},{"condition":"Partial-onset seizures","description":"Used as an add-on therapy with other anti-seizure medicines in adults with focal seizures.","evidence":"Well-established"},{"condition":"Spinal cord injury pain","description":"May help manage central neuropathic pain following spinal cord injury.","evidence":"Moderate"},{"condition":"Fibromyalgia","description":"Can reduce widespread muscle pain and improve sleep in some patients, though response varies.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Generalized anxiety disorder","description":"Sometimes prescribed off-label for short-term anxiety relief when other treatments are not suitable.","evidence":"Limited"},{"condition":"Chronic low back pain with nerve involvement","description":"May be used off-label when neuropathic components are suspected.","evidence":"Limited"},{"condition":"Restless legs syndrome","description":"Occasionally used off-label, but not first-line therapy.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Epilepsy (partial-onset seizures), Fibromyalgia, Generalized anxiety disorder (off-label)
📋 Drug Information
| Generic Name(s) | Pregabalin (25mg) |
| Brand Name | a2d capsule |
| Manufacturer | Bioceutics Inc |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Alpha 2 delta ligands (AED) |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it away from moisture, heat, and direct sunlight. Do not refrigerate unless specified. Keep it in its original container, tightly closed. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the pack before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the nervous system. This binding reduces the release of excitatory neurotransmitters such as glutamate, substance P, and noradrenaline. By calming these overactive nerve signals, it helps reduce nerve pain and prevents certain types of seizures. It does not act on GABA receptors directly, which distinguishes it from older anticonvulsants.
Mechanism Steps
💡 How to Take a2d capsule
Strength: This medicine is available as an immediate-release capsule containing 25 mg of Pregabalin.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine for neuropathic pain is 25 mg to 75 mg taken orally once or twice daily, depending on your condition and kidney function. For seizures, the starting dose is typically 25 mg to 75 mg twice daily. The dose may be gradually increased over several days to weeks based on your response and tolerability. The maximum recommended daily dose is 600 mg, but most patients do well on lower doses. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing for this medicine is not established from available information. Consult a pediatrician for appropriate guidance. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and drowsiness. Dose adjustment may be necessary based on kidney function, which often declines with age. Start with a low dose and increase gradually under medical supervision. |
| Renal Impairment | Dose adjustment is required in patients with reduced kidney function. The dose should be reduced based on creatinine clearance. For example, patients with moderate renal impairment may need half the usual dose, and those with severe impairment may need further reduction. Consult your doctor for personalized dosing. |
| Hepatic Impairment | No dose adjustment is typically required for patients with liver impairment, as this medicine undergoes negligible hepatic metabolism. However, consult your doctor for personalized advice. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 600 mg, divided into two or three doses. However, most patients do not need this high a dose. Never exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of a2d capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Morphine | Major | |
| Diazepam | Major | |
| Oxycodone | Major | |
| Lorazepam | Major | |
| Diphenhydramine | Moderate | |
| Baclofen | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Opioid pain medicines (e.g., morphine, oxycodone)
- Benzodiazepines (e.g., diazepam, lorazepam)
- Alcohol
⚡ Moderate Interactions
- Antihistamines (e.g., diphenhydramine)
- Muscle relaxants (e.g., baclofen)
🍷 Alcohol Interaction
Alcohol can increase the drowsiness, dizziness, and sedative effects of this medicine. It can also raise the risk of respiratory depression. It is strongly advised to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Pregabalin or any component of this medicine","Severe renal impairment requiring dose adjustment without medical supervision","Concurrent use with strong opioids without close monitoring"]
⚠️ Warnings & Precautions
["This medicine may cause dizziness and drowsiness. Do not drive or operate machinery until you know how it affects you.","Do not stop this medicine suddenly, as it can cause withdrawal symptoms such as insomnia, headache, nausea, and anxiety.","This medicine can increase the risk of suicidal thoughts. Report any changes in mood to your doctor immediately.","Use with caution in patients with respiratory conditions, as it can cause respiratory depression.","This medicine may cause peripheral edema and weight gain. Monitor your weight and report rapid swelling.","Avoid alcohol while taking this medicine.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Dose adjustment is required in patients with kidney problems."]
🤱 Lactation Safety
This medicine is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause excessive drowsiness, confusion, agitation, and respiratory depression. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include monitoring of vital signs and airway management. There is no specific antidote. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop it suddenly without medical advice, because abrupt withdrawal can cause unpleasant symptoms. Avoid driving, operating machinery, or doing activities that require full alertness until you know how this medicine affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Inform your doctor about all other medicines you take, especially opioid painkillers, sedatives, and antihistamines, because they can interact with this medicine. Keep this medicine out of reach of children and store it at room temperature away from moisture and heat. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Never double the dose to make up for a missed one. Regular follow-up with your doctor is important to monitor your response and adjust the dose if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and peripheral edema. Dose adjustment based on kidney function is often necessary. Regular monitoring for falls and confusion is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed. Your doctor may consider alternative treatments or adjust the dose.
🏥 Post-Surgery Considerations
This medicine may be used after surgery for neuropathic pain management. However, it can increase the risk of respiratory depression when combined with opioid pain medicines. Close monitoring is required in the postoperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with sedatives or anesthetics used during dental work. Your dentist may need to adjust the medications used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness and drowsiness, which may affect your balance and coordination. Avoid high-risk activities like heavy lifting or contact sports until you know how the medicine affects you. Gentle exercises like walking or yoga are generally safe, but consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is important to avoid these activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy machinery. Take frequent breaks if you feel drowsy during work.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects or your condition improves, your doctor may gradually reduce the dose. Abrupt discontinuation can cause withdrawal symptoms such as insomnia, headache, nausea, and anxiety.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to weight gain, peripheral edema, and dependence. Regular monitoring of kidney function, weight, and mood is recommended. Do not stop the medicine abruptly; taper gradually under medical supervision. Periodic review with your doctor is important to assess continued need and adjust the dose.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedHelps manage chronic pain and anxiety.
Evidence: ModerateMay provide relief for some types of neuropathic pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store it at room temperature and protect it from extreme heat or cold. If you are crossing time zones, consult your doctor about how to adjust your dosing schedule. Carry enough supply for the entire trip, and check customs regulations for controlled substances in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take several days to a few weeks to show its full effect. It is important to take it regularly as prescribed.
A: No, you should not stop this medicine suddenly as it can cause withdrawal symptoms. Always consult your doctor before stopping.
A: This medicine should be used during pregnancy only if the potential benefit justifies the potential risk. Consult your doctor if you are pregnant or planning to become pregnant.
A: It is advisable to avoid alcohol while taking this medicine, as it can increase drowsiness and dizziness.
🤔 Common Patient Concerns
🔄 Substitutes for a2d capsule
View AllAlternative brands with exact same active ingredient:
-
pregaqor 25 tabletInqor Pharmaceuticals Private Limited ₹46.88 23.1% CHEAPER
-
scribnor 25mg tabletRenauxe Pharma India Pvt Ltd ₹54.00 11.4% CHEAPER
-
Neurostab 25mg CapsuleStarus Pharmaceuticals ₹54.00 11.4% CHEAPER
-
veintree 25mg tabletZenolia Life Science Private Limited ₹56.25 7.7% CHEAPER
-
preganix 25mg tabletMedgenix Pharma India Pvt Ltd ₹74.06 21.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a simple painkiller like paracetamol.
Fact: This medicine is not a simple painkiller. It specifically targets nerve pain and seizures by calming overactive nerve signals. - Myth: You can stop this medicine whenever you feel better.
Fact: Stopping this medicine suddenly can cause withdrawal symptoms. Always consult your doctor before stopping. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the drowsiness and dizziness caused by this medicine and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Pregabalin 25 mg capsules (various manufacturers)
Brand Alternatives
- A2D Capsule