Alleviate Tablet: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
- Swelling of face, lips, or throat
- Difficulty breathing
- Severe headache with visual changes
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is a 3 100 mg/500 mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and not for more than 5-7 days without medical advice.
- Generic Name: Nimesulide + Paracetamol
- Manufacturer: Relax Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 a 3 100 mg/500 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग तीव्र दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और बुखार में राहत देती है। यह दवा सूजन पैदा करने वाले प्रोस्टाग्लैंडिन को कम करके काम करती है। इसे भोजन के साथ लेना चाहिए और बिना डॉक्टर की सलाह के 5-7 दिनों से अधिक नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला या खूनी मल, खून की उल्टी, गंभीर पेट दर्द, आंखों या त्वचा का पीलापन, पेशाब में कमी, या चेहरे, होंठ या गले में सूजन हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक या अवधि से अधिक न लें। पेट की जलन से बचने के लिए इसे भोजन या दूध के साथ लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे लीवर की क्षति और पेट में रक्तस्राव का खतरा बढ़ सकता है। बिना डॉक्टर की सलाह के पैरासिटामोल या अन्य NSAIDs वाली दवाएं न लें। यदि आपको पेट के अल्सर, लीवर या गुर्दे की बीमारी, अस्थमा या रक्तस्राव विकार है तो अपने डॉक्टर को बताएं।
💊 a 3 100 mg/500 mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and low back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"May be used for short-term relief of pain in osteoarthritis, but not for long-term management.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, but other NSAIDs are preferred.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever
📋 Drug Information
| Generic Name(s) | Nimesulide + Paracetamol |
| Brand Name | AP 100mg/325mg Tablet |
| Manufacturer | Relax Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system to produce analgesia and antipyresis, possibly by inhibiting prostaglandin synthesis in the brain and interfering with pain signals. Together, they provide enhanced pain relief and anti-inflammatory effects.
Mechanism Steps
💡 How to Take a 3 100 mg/500 mg tablet
Strength: Tablet containing nimesulide 100 mg and paracetamol 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (nimesulide 100 mg + paracetamol 500 mg) taken orally twice daily, preferably after meals. The maximum recommended duration is 5-7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years of age. Consult a pediatrician for appropriate alternatives. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with mild to moderate kidney impairment. Dose reduction may be necessary. Contraindicated in severe kidney impairment (eGFR <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with mild to moderate liver impairment. Dose reduction and close monitoring of liver function are recommended. Contraindicated in severe liver impairment. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum daily dose is two tablets (nimesulide 200 mg + paracetamol 1000 mg) per day. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of a 3 100 mg/500 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Antidiabetics | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Corticosteroids
- Methotrexate
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics
- Lithium
- SSRIs
- Antidiabetics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially from paracetamol, and increases the risk of gastrointestinal bleeding from nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active peptic ulcer or history of recurrent peptic ulcer.","Severe liver impairment or active liver disease.","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Take with food to reduce gastrointestinal irritation.","Do not exceed the recommended dose or duration of treatment.","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of side effects.","Use with caution in patients with dehydration, heart failure, or kidney disease.","Stop the medicine and consult a doctor if you experience signs of liver injury (yellowing of eyes or skin, dark urine, fatigue).","Do not use for more than 5-7 days without medical advice.","Inform your doctor if you are taking any other medications, especially blood thinners."]
🤱 Lactation Safety
Not recommended. Nimesulide may pass into breast milk and could harm the infant. Paracetamol is considered safe during breastfeeding. Consult your doctor for alternatives.
💊 Overdose Management
Overdose can cause severe liver damage, especially from paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, liver or kidney disease, asthma, or bleeding disorders. Do not use this medicine for more than 5-7 days unless directed by a doctor. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid concurrent use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy or who are pregnant. Nimesulide may interfere with ovulation and is contraindicated in the third trimester. Consult your doctor for safe pain relief options before conception and during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief, but it can increase the risk of bleeding and kidney problems. Inform your surgeon if you are taking this medicine before surgery. It is usually stopped before major surgeries. Follow your doctor's instructions for post-operative pain management.
🦷 Dental Procedures
This medicine can be used for dental pain and before dental procedures, but inform your dentist if you are taking it, as it may increase bleeding risk. It is generally safe for short-term use, but avoid taking it without dental advice if you have a bleeding disorder or are on anticoagulants.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or fatigue. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated. If your job involves physical labor, consult your doctor about modifications.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any serious side effects such as severe abdominal pain, black or bloody stools, yellowing of skin or eyes, decreased urine output, or allergic reactions. Also stop if your pain or fever persists beyond 5-7 days, and consult your doctor. Do not stop abruptly if you have been taking it for a prolonged period without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use can increase the risk of liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. It is generally safe to take this medicine before or after vaccination, but avoid taking it prophylactically to prevent fever unless advised by a doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it at the same intervals as prescribed, but consult your doctor for specific advice. Check local customs regulations regarding carrying prescription medicines. Always carry enough supply for your trip and keep it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol should be avoided while taking this medicine as it increases the risk of liver damage and gastrointestinal bleeding.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safe alternatives.
🤔 Common Patient Concerns
🔄 Substitutes for a 3 100 mg/500 mg tablet
View AllAlternative brands with exact same active ingredient:
-
Theraflam 100mg/500mg TabletParex Pharmaceuticals Pvt Ltd ₹2.50 92.6% CHEAPER
-
nulid plus 100mg/500mg tabletGeneral Pharmaceuticals Pvt Ltd ₹3.28 90.3% CHEAPER
-
alnim p 100 mg/500 mg tabletAlliaance Biotech ₹3.86 88.6% CHEAPER
-
nes forte tabletPCI Pharmaceuticals ₹4.22 87.6% CHEAPER
-
doliprane n 100 mg/500 mg tabletAbbott ₹4.45 86.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use. Prolonged use can cause liver and kidney damage. - Myth: It is safe to take this medicine on an empty stomach.
Fact: Taking it with food reduces the risk of stomach upset and bleeding. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol increases the risk of liver damage and gastrointestinal bleeding.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol generic tablets
Brand Alternatives
- Alleviate Tablet