a 3 100 mg/500 mg tablet - Nimesulide (100mg) + Paracetamol (500mg) medicine

Alleviate Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Relax Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute pain; limited for long-term use.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Yellowing of skin or eyes
  • Decreased urine output
  • Swelling of face, lips, or throat
  • Difficulty breathing
  • Severe headache with visual changes
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is a 3 100 mg/500 mg tablet used for?

This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and not for more than 5-7 days without medical advice.

  • Generic Name: Nimesulide + Paracetamol
  • Manufacturer: Relax Pharma
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 a 3 100 mg/500 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग तीव्र दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और बुखार में राहत देती है। यह दवा सूजन पैदा करने वाले प्रोस्टाग्लैंडिन को कम करके काम करती है। इसे भोजन के साथ लेना चाहिए और बिना डॉक्टर की सलाह के 5-7 दिनों से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला या खूनी मल, खून की उल्टी, गंभीर पेट दर्द, आंखों या त्वचा का पीलापन, पेशाब में कमी, या चेहरे, होंठ या गले में सूजन हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक या अवधि से अधिक न लें। पेट की जलन से बचने के लिए इसे भोजन या दूध के साथ लें। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे लीवर की क्षति और पेट में रक्तस्राव का खतरा बढ़ सकता है। बिना डॉक्टर की सलाह के पैरासिटामोल या अन्य NSAIDs वाली दवाएं न लें। यदि आपको पेट के अल्सर, लीवर या गुर्दे की बीमारी, अस्थमा या रक्तस्राव विकार है तो अपने डॉक्टर को बताएं।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 a 3 100 mg/500 mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and low back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain following dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"May be used for short-term relief of pain in osteoarthritis, but not for long-term management.","evidence":"Limited"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, but other NSAIDs are preferred.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever

📋 Drug Information

Generic Name(s)Nimesulide + Paracetamol
Brand NameAP 100mg/325mg Tablet
ManufacturerRelax Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to minimize stomach irritation.
2
Do not exceed the recommended dose of 2 tablets in 24 hours.
3
Limit the duration of use to 5-7 days unless otherwise directed by your doctor.
4
Avoid alcohol completely while taking this medicine to prevent liver damage.
5
Inform your doctor if you have a history of liver or kidney disease before taking this medicine.
6
Stop the medicine and seek medical help if you notice yellowing of eyes or skin, dark urine, or severe abdominal pain.
7
Do not take other paracetamol-containing products concurrently to avoid overdose.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Acute musculoskeletal pain
This medicine is commonly prescribed for this.
Likely Use
Dental pain
This medicine is effective for short-term relief of dental pain.
Likely Use
Fever
This medicine contains paracetamol which reduces fever.
Likely Use
Chronic pain
This medicine is not for long-term use; consult a doctor for chronic pain management.
Not Primary
Headache
This medicine may be used for acute headache but is not first-line.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed after oral administration, with peak plasma concentrations reached in 1.5-3 hours. Paracetamol is also rapidly absorbed, with peak levels in 0.5-2 hours. Food may delay absorption slightly but does not significantly affect the extent.
DistributionNimesulide is highly protein-bound and distributes well into tissues, including synovial fluid. Paracetamol distributes widely throughout body fluids and tissues.
Protein BindingNimesulide is approximately 99% bound to plasma proteins. Paracetamol is about 10-25% bound to plasma proteins.
MetabolismNimesulide is extensively metabolized in the liver, primarily by CYP2C9, to several metabolites, including 4-hydroxynimesulide, which is pharmacologically active. Paracetamol is metabolized in the liver via glucuronidation and sulfation, and a small fraction via CYP2E1 to N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione.
Half-LifeThe elimination half-life of nimesulide is approximately 1.8-4.7 hours. Paracetamol has a half-life of 2-3 hours.
ExcretionNimesulide metabolites are excreted mainly in urine (about 70%) and feces (about 20%). Paracetamol metabolites are excreted primarily in urine.
BioavailabilityNimesulide oral bioavailability is approximately 80-90%. Paracetamol oral bioavailability is about 80-100%.
Onset of ActionPain relief typically begins within 30-60 minutes after oral administration.
Peak Plasma TimeNimesulide: 1.5-3 hours; Paracetamol: 0.5-2 hours.
Duration of ActionPain relief lasts approximately 4-6 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system to produce analgesia and antipyresis, possibly by inhibiting prostaglandin synthesis in the brain and interfering with pain signals. Together, they provide enhanced pain relief and anti-inflammatory effects.

Mechanism Steps

1
COX-2 inhibition by nimesulide: Nimesulide selectively binds to and inhibits the COX-2 enzyme, reducing the conversion of arachidonic acid to prostaglandin H2, a precursor of pain and inflammation mediators.
2
Reduced prostaglandin synthesis: Decreased prostaglandin levels lead to less sensitization of pain receptors and reduced inflammation.
3
Central analgesic action of paracetamol: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis and modulate pain perception, though the exact mechanism is not fully understood.
4
Antipyretic effect: Both drugs act on the hypothalamus to reduce fever by inhibiting prostaglandin-mediated temperature elevation.

💡 How to Take a 3 100 mg/500 mg tablet

Strength: Tablet containing nimesulide 100 mg and paracetamol 500 mg.

1Take this medicine orally with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at the same times each day to maintain consistent levels.
5Do not take more than the prescribed dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose is one tablet (nimesulide 100 mg + paracetamol 500 mg) taken orally twice daily, preferably after meals. The maximum recommended duration is 5-7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. This medicine is not recommended for children under 12 years of age. Consult a pediatrician for appropriate alternatives.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney impairment. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with mild to moderate kidney impairment. Dose reduction may be necessary. Contraindicated in severe kidney impairment (eGFR <30 mL/min). Consult a doctor for dose adjustment.
Hepatic ImpairmentUse with caution in patients with mild to moderate liver impairment. Dose reduction and close monitoring of liver function are recommended. Contraindicated in severe liver impairment. Consult a doctor for dose adjustment.
Maximum Daily DoseThe maximum daily dose is two tablets (nimesulide 200 mg + paracetamol 1000 mg) per day. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of liver damage and gastrointestinal bleeding.
Grapefruit
Avoid
May increase drug levels and risk of side effects.

⏰ What to Do If You Miss a Dose

📌 Less than 6 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 6 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of a 3 100 mg/500 mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated. If vomiting is severe or persistent, seek medical advice.
Stomach pain (Common (5-10%))
Take with food or milk. Avoid alcohol. If pain is severe, contact your doctor.
Heartburn (Common (5-10%))
Take with food. Avoid lying down immediately after taking. Consult doctor if persistent.
Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea is severe or contains blood, seek medical attention.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Liver damage (Rare (<0.1%))
Stop the medicine and seek immediate medical help if you experience yellowing of skin or eyes, dark urine, or severe fatigue.
Kidney problems (Rare (<0.1%))
Seek medical attention if you notice decreased urine output, swelling in legs, or sudden weight gain.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you experience swelling of face, lips, or throat, difficulty breathing, or severe rash.

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Seek immediate medical attention if you develop a painful rash with blisters or peeling skin.
Agranulocytosis
Report any signs of infection such as fever, sore throat, or mouth ulcers immediately.
Aseptic meningitis
Seek medical help if you experience severe headache, stiff neck, fever, and sensitivity to light.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
ACE inhibitors Moderate
Diuretics Moderate
Lithium Moderate
SSRIs Moderate
Antidiabetics Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs
  • Corticosteroids
  • Methotrexate
  • ACE inhibitors and ARBs

⚡ Moderate Interactions

  • Diuretics
  • Lithium
  • SSRIs
  • Antidiabetics

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially from paracetamol, and increases the risk of gastrointestinal bleeding from nimesulide.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active peptic ulcer or history of recurrent peptic ulcer.","Severe liver impairment or active liver disease.","Severe kidney impairment (eGFR

⚠️ Warnings & Precautions

["Take with food to reduce gastrointestinal irritation.","Do not exceed the recommended dose or duration of treatment.","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of side effects.","Use with caution in patients with dehydration, heart failure, or kidney disease.","Stop the medicine and consult a doctor if you experience signs of liver injury (yellowing of eyes or skin, dark urine, fatigue).","Do not use for more than 5-7 days without medical advice.","Inform your doctor if you are taking any other medications, especially blood thinners."]

🤱 Lactation Safety

Not recommended. Nimesulide may pass into breast milk and could harm the infant. Paracetamol is considered safe during breastfeeding. Consult your doctor for alternatives.

💊 Overdose Management

Overdose can cause severe liver damage, especially from paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, liver or kidney disease, asthma, or bleeding disorders. Do not use this medicine for more than 5-7 days unless directed by a doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid concurrent use with other NSAIDs or anticoagulants.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended for women planning pregnancy or who are pregnant. Nimesulide may interfere with ovulation and is contraindicated in the third trimester. Consult your doctor for safe pain relief options before conception and during pregnancy.

🏥 Post-Surgery Considerations

This medicine may be used for short-term post-operative pain relief, but it can increase the risk of bleeding and kidney problems. Inform your surgeon if you are taking this medicine before surgery. It is usually stopped before major surgeries. Follow your doctor's instructions for post-operative pain management.

🦷 Dental Procedures

This medicine can be used for dental pain and before dental procedures, but inform your dentist if you are taking it, as it may increase bleeding risk. It is generally safe for short-term use, but avoid taking it without dental advice if you have a bleeding disorder or are on anticoagulants.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Engage in regular low-impact exercises like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods such as fruits, vegetables, and omega-3 rich fish in your diet.
🧘
Get adequate sleep to promote healing and pain tolerance.
🌞
Stay hydrated throughout the day.

🏋️ Exercise Considerations

While taking this medicine, you may experience dizziness or fatigue. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any exercise regimen.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Eat plenty of fruits and vegetables rich in antioxidants.
Stay well hydrated by drinking plenty of water.
Avoid alcohol and caffeine in excess.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated. If your job involves physical labor, consult your doctor about modifications.

🛑 When to Stop This Medicine

Stop taking this medicine if you experience any serious side effects such as severe abdominal pain, black or bloody stools, yellowing of skin or eyes, decreased urine output, or allergic reactions. Also stop if your pain or fever persists beyond 5-7 days, and consult your doctor. Do not stop abruptly if you have been taking it for a prolonged period without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use can increase the risk of liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term pain management is needed, consult your doctor for safer alternatives and regular monitoring of liver and kidney function.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Hot and cold therapy

Applying heat or cold packs can help reduce pain and inflammation.

Evidence: Well-established
Acupuncture

May provide pain relief for some individuals.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. It is generally safe to take this medicine before or after vaccination, but avoid taking it prophylactically to prevent fever unless advised by a doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it at the same intervals as prescribed, but consult your doctor for specific advice. Check local customs regulations regarding carrying prescription medicines. Always carry enough supply for your trip and keep it in your hand luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute low back pain
Ravi, a 45-year-old office worker, developed severe low back pain after lifting heavy boxes. His doctor prescribed this medicine twice daily with food. Within two days, his pain significantly reduced, and he was able to return to work. He was advised to take it for only five days and to avoid alcohol. He experienced mild nausea initially, which subsided when he took it with meals.
💡 Lesson: Taking this medicine with food reduces stomach upset and enhances tolerability. Short-term use as prescribed is effective for acute pain.
👤 A 30-year-old woman with dental pain
Priya, a 30-year-old woman, had a severe toothache and was prescribed this medicine before a root canal procedure. She took one tablet with breakfast and another with dinner. Her pain was well controlled, and she did not need additional painkillers. She was careful not to exceed the dose and avoided alcohol. She completed the course for three days without any side effects.
💡 Lesson: This medicine provides effective short-term relief for dental pain when taken as directed. Adhering to the prescribed dose and duration prevents complications.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is it safe to take this medicine with alcohol?

A: No, alcohol should be avoided while taking this medicine as it increases the risk of liver damage and gastrointestinal bleeding.

Q: Can I take this medicine during pregnancy?

A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safe alternatives.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe to take with other painkillers?

🔄 Substitutes for a 3 100 mg/500 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe for long-term use.
    Fact: This medicine is only for short-term use. Prolonged use can cause liver and kidney damage.
  • Myth: It is safe to take this medicine on an empty stomach.
    Fact: Taking it with food reduces the risk of stomach upset and bleeding.
  • Myth: This medicine can be taken with alcohol.
    Fact: Alcohol increases the risk of liver damage and gastrointestinal bleeding.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide + Paracetamol generic tablets

Brand Alternatives

  • Alleviate Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Nimesulide + Paracetamol","composition":"Nimesulide 100 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","gi_risk":"Moderate to high","liver_risk":"High"},{"medicine":"Ibuprofen + Paracetamol","composition":"Ibuprofen 400 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","gi_risk":"Moderate","liver_risk":"Moderate"},{"medicine":"Diclofenac + Paracetamol","composition":"Diclofenac 50 mg + Paracetamol 500 mg","onset":"30-60 minutes","duration":"4-6 hours","gi_risk":"High","liver_risk":"Moderate"}]

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