25 D Infusion
Clinical Background: Balrampur Hospital, Lucknow (Emergency Medicine) & SCPM Hospital | Standards: CDSCO, Indian Pharmacopoeia (IP) & WHO
When to Call Your Doctor IMMEDIATELY
- Severe hyperglycemia with confusion or fruity breath
- Signs of fluid overload: shortness of breath, swelling, rapid weight gain
- Infection at infusion site: fever, chills, pus
- Thrombosis: swelling, pain, redness in limb
- Allergic reaction: rash, itching, difficulty breathing
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is 25 D Infusion used for?
This medicine is a 25% dextrose intravenous infusion used to treat low blood sugar and provide calories in patients who cannot eat. It is given by healthcare professionals in a hospital setting.
- Generic Name: Dextrose (25% w/v)
- Manufacturer: Claris Lifesciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 25 D Infusion के बारे में (Hindi Summary)
उपयोग: यह दवा 25% डेक्सट्रोज़ इन्फ्यूजन है, जिसका उपयोग खून में शर्करा की कमी (हाइपोग्लाइसीमिया) को तुरंत ठीक करने और उन रोगियों को कैलोरी प्रदान करने के लिए किया जाता है जो मुंह से भोजन नहीं ले सकते। यह अस्पताल में डॉक्टर की देखरेख में नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में उच्च रक्त शर्करा, इंजेक्शन स्थल पर दर्द या सूजन, और तरल पदार्थ की अधिकता शामिल हैं। गंभीर दुष्प्रभावों में गंभीर हाइपरग्लाइसीमिया, संक्रमण, और थ्रोम्बोसिस हो सकते हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल में ही दी जानी चाहिए। इसे स्वयं न लें। यदि आपको मधुमेह, गुर्दे की समस्या, या हृदय की विफलता है, तो अपने डॉक्टर को बताएं। उपचार के दौरान रक्त शर्करा और इलेक्ट्रोलाइट की निगरानी की जाएगी। इन्फ्यूजन स्थल पर दर्द, सूजन या लालिमा होने पर तुरंत बताएं।
25 D Infusion Uses & Benefits
Used to rapidly correct low blood sugar levels in patients who are unconscious or unable to take oral glucose.
Provides a concentrated source of calories for patients who cannot eat or absorb food through the gastrointestinal tract.
Helps maintain hydration and provides glucose as an energy source when oral intake is not possible.
Sometimes used as part of therapy to reduce brain swelling due to its osmotic effect, though mannitol is more commonly used.
Off-Label & Investigational Uses:
May be used to treat hypoglycemia associated with alcohol intoxication, but this is not a primary indication.
Combined with insulin to shift potassium into cells in emergency treatment of high potassium levels.
📋 Drug Information
| Generic Name(s) | Dextrose (25% w/v) |
| Brand Name | 25 D Infusion |
| Manufacturer | Claris Lifesciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store at room temperature (15-30°C). Do not freeze. Keep in original container. Protect from light and moisture. |
| Shelf Life | Typically 24-36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine provides glucose directly into the bloodstream. Glucose is the primary energy source for cells and is essential for cellular metabolism. When administered intravenously, it rapidly increases blood glucose levels, which can be taken up by cells and used for energy production. In the brain, glucose is the main fuel, and maintaining adequate levels is critical for normal neurological function. The hypertonic nature of the 25% solution also draws fluid out of tissues into the bloodstream, which can help reduce edema in certain conditions. The body regulates glucose levels through insulin and glucagon, but in cases of severe hypoglycemia, exogenous glucose is needed to restore normal levels quickly.
Mechanism Steps
💡 How to Take 25 D Infusion
Strength: 25% w/v infusion, meaning 25 grams of dextrose per 100 mL of solution.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's condition, blood glucose levels, fluid requirements, and renal and hepatic function. For hypoglycemia, a common dose is 25-50 mL of 25% dextrose intravenously, which may be repeated as needed. For parenteral nutrition, the dose depends on caloric needs and is part of a total nutrition regimen. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Doses are typically weight-based and must be determined by a qualified clinician. |
| Elderly Dosage | Elderly patients may be more susceptible to fluid overload and electrolyte imbalances. Doses should be adjusted based on renal and cardiac function. Close monitoring is required. |
| Renal Impairment | In patients with renal impairment, the dose may need to be reduced, and fluid and electrolyte balance should be monitored closely to avoid overload. |
| Hepatic Impairment | No specific dosage adjustment is typically required for hepatic impairment, but glucose metabolism may be affected. Monitor blood glucose levels. |
| Maximum Daily Dose | The maximum daily dose is determined by the patient's caloric and fluid needs and must not exceed the clinician's prescription. There is no fixed maximum; it is individualized. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of 25 D Infusion
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Potassium-sparing diuretics | Major | |
| Corticosteroids | Moderate | |
| Thiazide diuretics | Moderate | |
| Beta-blockers | Minor |
🚨 Major Interactions
- Insulin
- Potassium-sparing diuretics
⚡ Moderate Interactions
- Corticosteroids
- Thiazide diuretics
🍷 Alcohol Interaction
Alcohol can affect blood glucose levels and may increase the risk of hypoglycemia or hyperglycemia. It is advisable to avoid alcohol while receiving this medicine, as it can complicate glucose control.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hyperglycemia","Severe dehydration","Anuria","Severe heart failure","Pulmonary edema","Known hypersensitivity to dextrose","Patients with intracranial hemorrhage (unless specifically indicated)"]
⚠️ Warnings & Precautions
["Administer with caution in patients with diabetes mellitus.","Use with caution in patients with renal impairment.","Avoid rapid infusion to prevent osmotic diuresis.","Ensure proper placement of intravenous line to avoid extravasation.","Monitor for signs of fluid overload.","Do not use if solution is cloudy or contains particles.","Use aseptic technique to prevent infection."]
🤱 Lactation Safety
Dextrose is distributed into breast milk, but it is a normal component of breast milk. Intravenous dextrose is considered safe during breastfeeding when clinically indicated. Consult your doctor.
💊 Overdose Management
Overdose can lead to severe hyperglycemia, osmotic diuresis, dehydration, and electrolyte imbalances. Treatment includes stopping the infusion, monitoring blood glucose and electrolytes, and administering insulin if necessary. Supportive care in a hospital setting is required.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a controlled setting. Missed doses are not applicable for patients self-administering. If a scheduled infusion is missed, the healthcare team will adjust the schedule accordingly.
Additional Safety Advice
This medicine must only be administered by a qualified healthcare professional in a clinical setting. Do not attempt to self-administer this medicine. Inform your doctor if you have diabetes, kidney problems, heart failure, or any condition that affects fluid balance. Your blood sugar levels and electrolyte levels will be monitored during treatment. Report any pain, swelling, or redness at the infusion site immediately. Do not use this medicine if the solution is cloudy, discolored, or contains particles. Ensure that the infusion is given through a central line if required, as the 25% concentration can irritate peripheral veins. Follow your doctor's instructions regarding food and fluid intake. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. Keep this medicine out of reach of children. Store as directed by the manufacturer.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to fluid overload and electrolyte imbalances. Close monitoring of renal and cardiac function is necessary. Doses should be adjusted accordingly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. Dextrose is used in pregnancy when clinically indicated. It is considered safe when used appropriately.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to provide fluids and calories until oral intake resumes. It helps maintain blood sugar and hydration. Monitor for signs of infection at the surgical site and infusion site.
🦷 Dental Procedures
If you are scheduled for dental procedures, inform your dentist if you are receiving this medicine. It is unlikely to affect dental work, but your blood sugar should be stable.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may be restricted to bed rest or limited activity. Follow your doctor's advice regarding physical activity. Avoid strenuous exercise until you are fully recovered.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinical setting, so it may require time off work. You should not drive or operate machinery immediately after receiving this medicine, especially if you experienced hypoglycemia. Follow your doctor's advice before resuming normal activities.
🛑 When to Stop This Medicine
This medicine is stopped by your healthcare provider when your blood sugar is stable and you can eat normally, or when the infusion is no longer needed. Do not stop it on your own. If you experience any adverse effects, inform your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is generally not associated with adverse effects when monitored appropriately. However, prolonged hyperglycemia can lead to complications such as infections, delayed wound healing, and electrolyte imbalances. Regular monitoring of blood glucose and electrolytes is essential. In patients on parenteral nutrition, liver function should be monitored. When oral intake resumes, the infusion should be tapered off.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild hypoglycemia, oral glucose tablets or sugary drinks can be used if the patient is conscious.
Evidence: Well-establishedFor severe hypoglycemia when IV access is not available.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines. However, if you are ill, vaccination may be postponed. Consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not use if solution is cloudy or discolored
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel advice is not applicable for patients. If you are traveling with this medicine for medical purposes, carry it in its original packaging with a prescription and medical documentation. Store at room temperature and protect from extreme temperatures. Check customs regulations for carrying medical fluids.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine works immediately. Blood glucose levels begin to rise within minutes of infusion.
A: Yes, if you are able to eat, but the medicine is usually given when oral intake is not possible. Follow your doctor's advice.
A: No, dextrose is a sugar and is not addictive.
🤔 Common Patient Concerns
🔄 Substitutes for 25 D Infusion
View AllAlternative brands with exact same active ingredient:
-
dextrose 25% infusionClaris Lifesciences Ltd ₹17.51 29.3% COSTLIER
-
aculife 25% infusionNirlife Healthcare ₹17.63 30.2% COSTLIER
-
dex 25% infusionShree KrishnaKeshav Laboratories Ltd ₹20.63 52.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Dextrose 25% can be given through any vein.
Fact: It must be given through a central line due to its high concentration, which can damage peripheral veins. - Myth: Dextrose is only for diabetics.
Fact: Dextrose is used for many conditions, including hypoglycemia and parenteral nutrition, not just diabetes.
🔄 Alternative Options
Generic Alternatives
- Dextrose 25% w/v infusion (generic)
Brand Alternatives
- Dex 25% infusion