Acebrophylline 50mg Syrup: Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Rapid or irregular heartbeat
- Seizures
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Blood in vomit or stool
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is zysma syrup used for?
Acebrophylline 50 mg syrup is a bronchodilator and mucolytic used to treat asthma, COPD, and bronchitis. It relaxes airways and thins mucus, making breathing easier. It is not for acute attacks.
- Generic Name: Acebrophylline (50mg)
- Manufacturer: Zodley Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zysma syrup के बारे में (Hindi Summary)
उपयोग: यह दवा एसब्रोफिलिन 50 मिलीग्राम सिरप है, जिसका उपयोग अस्थमा, सीओपीडी और ब्रोंकाइटिस जैसी श्वसन संबंधी समस्याओं के इलाज में किया जाता है। यह वायुमार्ग की मांसपेशियों को आराम देकर और बलगम को पतला करके सांस लेने में मदद करती है। यह दवा तीव्र अस्थमा हमले के लिए नहीं है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, सिरदर्द और बेचैनी शामिल हैं। गंभीर दुष्प्रभावों में दिल की धड़कन तेज होना, दौरे पड़ना और एलर्जी की प्रतिक्रिया शामिल हो सकती है। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इस दवा के साथ शराब का सेवन न करें। यदि आपको हृदय, यकृत, गुर्दे की बीमारी या दौरे की समस्या है तो डॉक्टर को बताएं। तीव्र अस्थमा हमले के लिए इसका उपयोग न करें। बच्चों की पहुंच से दूर रखें।
💊 zysma syrup Uses & Benefits
[{"condition":"Asthma","description":"Helps in the management of bronchial asthma by relaxing airways and reducing mucus.","evidence":"Well-established"},{"condition":"Chronic Obstructive Pulmonary Disease (COPD)","description":"Used to relieve bronchospasm and improve breathing in COPD patients.","evidence":"Well-established"},{"condition":"Bronchitis","description":"Aids in loosening mucus and easing cough in acute and chronic bronchitis.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Sinusitis","description":"Sometimes prescribed off-label to help with mucus clearance in sinusitis.","evidence":"Limited"}]
Primary treatment for: Asthma
Also treats: COPD, Bronchitis
📋 Drug Information
| Generic Name(s) | Acebrophylline (50mg) |
| Brand Name | zysma syrup |
| Manufacturer | Zodley Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Theophylline & its derivatives |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Acebrophylline is a xanthine derivative that combines the bronchodilator effects of theophylline with the mucolytic properties of ambroxol. It works by inhibiting phosphodiesterase enzymes, leading to increased cyclic AMP levels, which relaxes bronchial smooth muscle. Additionally, it reduces mucus viscosity and enhances mucociliary clearance, making it easier to cough out mucus. It also has anti-inflammatory effects by inhibiting the release of inflammatory mediators from mast cells and neutrophils.
Mechanism Steps
💡 How to Take zysma syrup
Strength: Syrup containing 50 mg of acebrophylline per 5 mL.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 50 mg to 100 mg two to three times daily, depending on the severity of the condition and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require lower doses due to reduced renal and hepatic function. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be needed in patients with renal impairment. Consult your doctor. |
| Hepatic Impairment | Dose adjustment may be needed in patients with hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is 300 mg, but this should not be exceeded without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zysma syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Erythromycin | Major | |
| Beta-blockers | Moderate | |
| Diuretics | Moderate | |
| Cimetidine | Minor |
🚨 Major Interactions
- Ciprofloxacin
- Erythromycin
⚡ Moderate Interactions
- Beta-blockers
- Diuretics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine as it may increase the risk of side effects such as dizziness, drowsiness, and gastrointestinal upset.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to acebrophylline or any component","Severe liver disease","Severe kidney disease","Uncontrolled cardiac arrhythmias","Acute asthma attack"]
⚠️ Warnings & Precautions
["Not for acute asthma attacks.","Use with caution in patients with peptic ulcer disease.","May impair ability to drive or operate machinery.","Avoid in patients with seizure disorders.","Monitor closely in elderly patients."]
🤱 Lactation Safety
It is not known whether acebrophylline is excreted in human breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause nausea, vomiting, tachycardia, seizures, and cardiac arrhythmias. Seek immediate medical attention. Treatment is symptomatic and supportive. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol while taking this medicine as it may increase the risk of side effects. Inform your doctor if you have a history of heart disease, liver disease, kidney disease, or seizures. Do not use this medicine for acute asthma attacks; use your rescue inhaler instead. Keep out of reach of children. Store at room temperature away from moisture and heat. If you are pregnant or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Dose adjustment may be needed based on renal and hepatic function. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning to become pregnant or are pregnant. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. It may interact with anesthetic agents.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may cause dry mouth or interact with medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you have breathing difficulties. Consult your doctor before starting any exercise program. Gentle activities like walking may be beneficial.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause restlessness, so take it as prescribed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately. Your doctor will determine if and when to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of liver and kidney function, as well as heart rate. It is generally well-tolerated, but prolonged use should be under medical supervision. Do not stop suddenly without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help loosen mucus and ease breathing.
Evidence: Well-establishedHelps clear nasal passages and reduce congestion.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Ensure you are up to date with influenza and pneumococcal vaccines if you have chronic respiratory conditions. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: Yes, but inform your doctor about all medicines you are taking to avoid interactions.
A: Pediatric dosing is not established. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for zysma syrup
View AllAlternative brands with exact same active ingredient:
-
acezec 50mg syrupBiozec Healthcare ₹79.69 3.4% CHEAPER
-
cibrolly 50mg syrupTrireme Life Sciences Pvt Ltd ₹85.00 3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Acebrophylline can be used for immediate relief of asthma attacks.
Fact: Acebrophylline is not a rescue medication. It is used for maintenance therapy. For acute attacks, use a rescue inhaler. - Myth: Acebrophylline is safe to take without a prescription.
Fact: Acebrophylline is a prescription medicine and should only be taken under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Acebrophylline 50 mg syrup
Brand Alternatives
- Acezec 50mg Syrup