Mimod Tablet (Iguratimod 25mg): Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes, dark urine, or severe fatigue (signs of liver injury).
- Fever, chills, persistent cough, or burning urination (signs of infection).
- Unusual bruising or bleeding, such as bleeding gums or nosebleeds (signs of low platelets).
- Severe abdominal pain, especially upper abdominal pain radiating to the back (possible pancreatitis).
- Shortness of breath, dry cough, or chest discomfort (possible lung involvement).
- Swelling of the face, lips, tongue, or throat, or difficulty breathing (severe allergic reaction).
- Severe skin rash with blisters, peeling skin, or sores in the mouth or eyes (serious skin reaction).
- Decreased urine output or swelling in the legs (possible kidney problem).
If experiencing severe symptoms, call emergency services immediately.
What is zyramod 25 tablet used for?
This medicine contains Iguratimod 25 mg, a disease-modifying antirheumatic drug (DMARD) used to treat active rheumatoid arthritis in adults. It works by reducing inflammation and suppressing the immune system. It is taken orally, usually once or twice daily with food, and requires regular blood tests to monitor liver function and blood counts. It is not recommended during pregnancy or breastfeeding.
- Generic Name: Iguratimod (25mg)
- Manufacturer: Zydus Cadila
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zyramod 25 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इगुराटिमोड 25 मिलीग्राम युक्त एक टैबलेट है, जिसका उपयोग वयस्कों में सक्रिय रूमेटॉयड आर्थराइटिस (गठिया) के इलाज के लिए किया जाता है। यह एक डीएमएआरडी (रोग-संशोधक एंटीरूमेटिक दवा) है जो शरीर की प्रतिरक्षा प्रणाली को नियंत्रित करके जोड़ों की सूजन, दर्द और अकड़न को कम करती है। यह दवा जोड़ों के नुकसान को धीमा करने में भी मदद करती है। इसे आमतौर पर भोजन के साथ मुँह से लिया जाता है, दिन में एक या दो बार। इसका असर धीरे-धीरे होता है, इसलिए कुछ हफ्तों से लेकर महीनों तक इसे नियमित रूप से लेना पड़ता है। इस दवा को लेते समय लीवर की कार्यप्रणाली और रक्त कोशिकाओं की नियमित जाँच बहुत जरूरी है। गर्भवती महिलाओं, स्तनपान कराने वाली महिलाओं और गंभीर लीवर रोग वाले मरीजों को यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में लीवर एंजाइम का बढ़ना, पेट में गड़बड़ी, जी मिचलाना, सिरदर्द और हल्की त्वचा पर चकत्ते शामिल हैं। कुछ मरीजों में सफेद रक्त कोशिकाओं या प्लेटलेट्स की संख्या कम हो सकती है, जो आमतौर पर खून की जाँच से पता चलती है। दुर्लभ मामलों में गंभीर लीवर की क्षति, गंभीर संक्रमण, या अस्थि मज्जा की गंभीर कमी हो सकती है। अगर आपको लगातार थकान, आसानी से चोट लगना, आँखों या त्वचा का पीलापन, गहरे रंग का पेशाब, या बुखार जैसे संक्रमण के लक्षण दिखें, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के बताए अनुसार ही लें, आमतौर पर भोजन के साथ, दिन में एक या दो बार। टैबलेट को चबाएं या तोड़ें नहीं। इलाज शुरू करने से पहले और दौरान नियमित रूप से लीवर फंक्शन, किडनी फंक्शन और ब्लड काउंट की जाँच कराना जरूरी है। इस दवा के साथ शराब बिल्कुल न लें क्योंकि इससे लीवर को नुकसान का खतरा बढ़ जाता है। अपने डॉक्टर को अन्य सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। गर्भवती, गर्भधारण की योजना बना रही महिलाएं, या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के यह दवा न लें। इस दवा को कमरे के तापमान पर, मूल डिब्बे में, धूप और नमी से दूर रखें।
💊 zyramod 25 tablet Uses & Benefits
[{"condition":"Rheumatoid Arthritis","description":"This medicine is used to reduce signs and symptoms, improve physical function, and slow joint damage in adults with active rheumatoid arthritis, especially when conventional DMARDs have not worked well enough.","evidence":"Well-established in several clinical studies and approved in multiple countries for this indication."},{"condition":"Combination therapy with Methotrexate","description":"Often prescribed alongside methotrexate to enhance treatment response in patients with inadequate control on methotrexate alone.","evidence":"Supported by clinical trial data showing improved outcomes when used in combination."}]
Off-label uses: [{"condition":"Other autoimmune arthritides","description":"Occasionally considered by specialists for conditions like psoriatic arthritis or ankylosing spondylitis, but this is not a standard approved use.","evidence":"Limited; not established from large controlled trials."}]
Primary treatment for: Rheumatoid Arthritis
Also treats: Other inflammatory arthritides (off-label), Autoimmune conditions (off-label, limited evidence)
📋 Drug Information
| Generic Name(s) | Iguratimod (25mg) |
| Brand Name | zyramod 25 tablet |
| Manufacturer | Zydus Cadila |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Disease Modifying Anti-Rheumatoid Drugs (DMARDs)- Non biologics |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Keep it in the original container, tightly closed, away from direct sunlight and moisture. Do not refrigerate unless specifically instructed. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture, but refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. Iguratimod is approved in some countries for rheumatoid arthritis, but specific WHO guideline recommendations are not available. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for rheumatoid arthritis management may include conventional DMARDs; Iguratimod is not specifically mentioned in publicly available ICMR guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting key inflammatory signalling pathways involved in rheumatoid arthritis. It suppresses the activation of nuclear factor-kappa B (NF-κB), a master switch for many inflammatory genes, and reduces the production of pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-17 (IL-17), and tumour necrosis factor-alpha (TNF-α). It also inhibits the proliferation of activated T cells and B cells, and reduces the production of matrix metalloproteinases that destroy joint cartilage. Additionally, it may interfere with the JAK-STAT signalling pathway, contributing to its immunomodulatory effects. The overall result is a reduction in joint inflammation, pain, and structural damage.
Mechanism Steps
💡 How to Take zyramod 25 tablet
Strength: This medicine is available as an immediate-release tablet containing 25 mg of Iguratimod.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 25 mg taken orally once or twice daily, as prescribed by your rheumatologist. The exact dose and frequency depend on your condition, response to treatment, and tolerance. Some patients may be started on 25 mg once daily and increased to 25 mg twice daily after assessing tolerability and blood test results. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's instructions and never self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, particularly liver and kidney effects. Dose adjustment may be necessary based on liver and kidney function. Regular monitoring is especially important in this age group. Consult your doctor for individualized dosing. |
| Renal Impairment | Dose adjustment may be required in patients with kidney impairment. In mild to moderate renal impairment, no specific dose adjustment is generally recommended, but close monitoring is advised. In severe renal impairment, this medicine should be used with caution or avoided, as safety and efficacy have not been established. Consult your doctor for personalized dosing. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe liver impairment. In mild to moderate liver impairment, dose reduction or cautious use with close monitoring of liver function tests is advised. The exact dose adjustment is not established from available information. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 50 mg (25 mg twice daily). Do not exceed this dose unless specifically instructed by your rheumatologist. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zyramod 25 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Warfarin | Major | |
| Live vaccines | Major | |
| NSAIDs | Moderate | |
| Fluconazole | Moderate | |
| Ketoconazole | Moderate | |
| Clarithromycin | Moderate | |
| Antacids | Minor | |
| St. John's wort | Minor | |
| Rifampicin | Moderate |
🚨 Major Interactions
- Methotrexate
- Warfarin
- Live vaccines
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, diclofenac)
- CYP2C9 inhibitors (e.g., fluconazole)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both alcohol and this medicine can stress the liver, and combining them significantly increases the risk of liver injury. If you consume alcohol regularly, discuss this with your doctor before starting treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to Iguratimod or any component of the tablet.","Severe liver impairment or active liver disease.","Active serious infections (e.g., tuberculosis, sepsis).","Severe bone marrow suppression or blood disorders.","Pregnancy and breastfeeding.","Women of childbearing potential not using effective contraception.","Severe kidney impairment (dose adjustment or avoidance may be required)."]
⚠️ Warnings & Precautions
["This medicine can cause serious liver injury. Report symptoms like yellowing of eyes or skin, dark urine, or severe fatigue immediately.","Immune suppression may increase the risk of infections. Avoid contact with people who have contagious infections and practice good hygiene.","Live vaccines should not be administered during treatment.","Regular blood tests are essential to monitor liver enzymes, blood counts, and kidney function.","Avoid alcohol completely while taking this medicine.","This medicine may cause dizziness or blurred vision in some patients. Do not drive or operate machinery until you know how it affects you.","Inform your doctor if you have a history of tuberculosis, hepatitis, or other chronic infections.","Do not stop or change the dose without consulting your rheumatologist."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in a breastfed infant, breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
There is no specific antidote for an overdose of this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be symptomatic and supportive, with close monitoring of liver function, blood counts, and vital signs. Gastric lavage may be considered if the overdose was recent and the patient is seen in a healthcare facility. Contact a poison control center or emergency department right away.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, provided it is not almost time for your next dose. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your rheumatologist, usually once or twice daily with food to reduce stomach upset. Do not crush, chew, or split the tablet unless your doctor advises otherwise. Regular blood tests to check liver function, kidney function, and blood cell counts are mandatory before starting and at periodic intervals during treatment. Avoid alcohol completely while taking this medicine because it increases the risk of liver damage. Inform your doctor about all other medicines, supplements, and herbal products you are taking, as this medicine can interact with several drugs. Do not receive live vaccines without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, do not take this medicine without explicit medical advice. Store the tablets in their original container at room temperature, away from moisture and direct sunlight. Never share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Patients above 65 years may be more susceptible to side effects, particularly liver and kidney toxicity, and infections. Regular monitoring of liver function, kidney function, and blood counts is especially important. Dose adjustment may be necessary based on organ function. Elderly patients should also be monitored for falls and bone health, as rheumatoid arthritis and its treatments can affect mobility and bone density.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy and should be stopped before attempting conception. Women of childbearing potential must use effective contraception during treatment and for a period after stopping, as advised by their doctor. If you are planning pregnancy, discuss alternative treatment options with your rheumatologist well in advance. Do not become pregnant while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery due to increased risk of infection and impaired wound healing. Your doctor will advise on when to stop and when to restart. Close monitoring for infection is important after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure, especially if it involves bleeding or infection risk. This medicine may increase the risk of infection and bleeding. Your dentist may recommend antibiotics before certain procedures. Do not stop the medicine without consulting your rheumatologist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While exercise is beneficial for rheumatoid arthritis, avoid high-impact activities that stress your joints, especially during flare-ups. Consult your doctor or physiotherapist before starting any new exercise routine. If you experience increased joint pain, swelling, or fatigue after exercise, rest and modify your routine. Swimming and water aerobics are generally safe and effective. Always warm up before exercise and cool down afterward.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or blurred vision in some patients, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. Most patients can continue their normal work activities, but those with physically demanding jobs may need to modify tasks during flare-ups. Fatigue is common with rheumatoid arthritis; plan your day with rest breaks. Inform your employer about your condition if you need accommodations. Regular follow-up appointments may require time off work, so plan accordingly.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your rheumatologist. If you experience serious side effects such as severe liver injury, serious infection, or severe allergic reaction, stop the medicine and seek immediate medical attention. Your doctor may decide to stop or change the medicine if blood tests show significant abnormalities, if your condition improves significantly, or if you become pregnant. Always follow your doctor's guidance on when and how to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may be necessary to control rheumatoid arthritis and prevent joint damage. Regular monitoring of liver function, kidney function, and blood counts is essential throughout treatment. Some patients may develop persistent liver enzyme elevation or blood count abnormalities, which may require dose adjustment or discontinuation. The risk of serious infections may increase with prolonged immune suppression. Periodic assessment of treatment response and side effects by a rheumatologist is recommended. Do not stop the medicine without medical advice, as this can lead to disease flare.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine to improve joint function, reduce pain, and maintain mobility.
Evidence: Well-establishedHelps with joint protection techniques and assistive devices for daily activities.
Evidence: Well-establishedAnti-inflammatory diet may help reduce symptoms, but is not a substitute for DMARDs.
Evidence: ModerateMay help with pain relief in some patients, but evidence is mixed.
Evidence: LimitedYoga, tai chi, and meditation can improve quality of life and reduce stress.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be administered while taking this medicine due to immune suppression. Inactivated vaccines are generally safe but may be less effective. Consult your doctor before receiving any vaccine. It is advisable to complete recommended vaccinations, such as influenza and pneumococcal vaccines, before starting this medicine if possible.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless specifically instructed.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a letter from your doctor explaining the medical need, especially for international travel. Keep the medicine in your carry-on luggage to avoid loss or temperature extremes in checked baggage. Store at room temperature and avoid leaving it in a hot car or direct sunlight. If crossing time zones, continue taking your doses at the same intervals as prescribed; you may need to adjust timing gradually. Check local customs regulations for controlled substances, though this medicine is generally not a controlled drug. Carry enough supply for your entire trip plus extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working gradually. Some patients may notice improvement in joint pain and stiffness within 2 to 4 weeks, but full benefits typically take 8 to 12 weeks or longer. It is important to take it consistently as prescribed.
A: Yes, this medicine is sometimes prescribed in combination with methotrexate for better control of rheumatoid arthritis. However, this combination requires close monitoring of liver function and blood counts by your doctor.
A: If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is nearly time, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine is not recommended during pregnancy as it may harm the developing baby. Women of childbearing potential must use effective contraception during treatment and for a period after stopping, as advised by their doctor.
A: No, alcohol should be completely avoided while taking this medicine because it increases the risk of liver damage.
A: Seek immediate medical attention if you experience yellowing of eyes or skin, dark urine, severe fatigue, fever, persistent cough, unusual bruising or bleeding, severe abdominal pain, shortness of breath, or swelling of face, lips, or throat.
🤔 Common Patient Concerns
🔄 Substitutes for zyramod 25 tablet
View AllAlternative brands with exact same active ingredient:
-
igumod 25mg tabletMedley Pharmaceuticals ₹220.31 28.7% CHEAPER
-
iguvic 25 tabletHetero Drugs Ltd ₹262.50 15% CHEAPER
-
igurati 25mg tabletIpca Laboratories Ltd ₹324.09 5% COSTLIER
-
redimard 25mg tabletDr Reddy's Laboratories Ltd ₹339.14 9.8% COSTLIER
-
mimod tabletAjanta Pharma Ltd ₹459.00 48.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller that works immediately.
Fact: This medicine is a DMARD that works slowly by modifying the immune system. It may take several weeks to months for full benefits. - Myth: Once I feel better, I can stop taking this medicine.
Fact: Rheumatoid arthritis is a chronic condition. Stopping this medicine without medical advice can lead to flare-ups and joint damage. Always consult your doctor before stopping. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is not recommended during pregnancy as it may harm the developing baby. Effective contraception is essential for women of childbearing potential. - Myth: This medicine can be taken without regular blood tests.
Fact: Regular blood tests are mandatory to monitor liver function, blood counts, and kidney function while on this medicine. - Myth: This medicine can be shared with others who have joint pain.
Fact: This medicine is prescribed for specific conditions and must never be shared. It requires medical supervision and monitoring.
🔄 Alternative Options
Generic Alternatives
- Iguratimod 25 mg tablet (generic)
Brand Alternatives
- Mimod Tablet