Histodar Syrup: Complete Medicine Guide for Cold and Allergy Relief
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Fast, irregular, or pounding heartbeat.
- Severe headache with blurred vision or confusion.
- Inability to pass urine or severe lower abdominal pain.
- Seizures or loss of consciousness.
- Yellowing of the skin or eyes, dark urine, or severe fatigue.
- Unusual bruising or bleeding.
- High fever with rash or severe allergic reaction.
If experiencing severe symptoms, call emergency services immediately.
What is zumokuf d syrup used for?
This medicine is a combination syrup containing phenylephrine, a decongestant, and chlorpheniramine maleate, an antihistamine. It is used to relieve nasal congestion, sneezing, runny nose, and itchy watery eyes caused by allergies or the common cold. It is taken orally, usually every 4 to 6 hours as needed, and may cause drowsiness.
- Generic Name: Phenylephrine (12.5mg) + Chlorpheniramine Maleate (2mg)
- Manufacturer: Mathis Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zumokuf d syrup के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी और सर्दी-जुकाम के लक्षणों से राहत दिलाने के लिए इस्तेमाल की जाती है। इसमें फेनिलएफ्रिन और क्लोरफेनिरामिन मेलिएट होते हैं। फेनिलएफ्रिन नाक की भीड़ को कम करता है, जबकि क्लोरफेनिरामिन छींक, बहती नाक और आंखों की खुजली को कम करता है। यह दवा मौसमी एलर्जी, सर्दी-जुकाम और ऊपरी श्वसन एलर्जी में उपयोगी है। इसे मुंह से लिया जाता है और इससे नींद आ सकती है, इसलिए गाड़ी चलाते समय सावधानी बरतें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुंह सूखना, चक्कर आना, सिरदर्द, जी मिचलाना और धुंधली दृष्टि शामिल हैं। कभी-कभी दिल की धड़कन तेज होना, पेशाब करने में कठिनाई, भ्रम या एलर्जी जैसी गंभीर समस्याएं हो सकती हैं। अगर चेहरे, होंठ या गले में सूजन, सांस लेने में तकलीफ या तेज धड़कन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपने आप मात्रा न बढ़ाएं। शराब और नींद लाने वाली दवाओं के साथ इसका सेवन न करें। अगर आपको उच्च रक्तचाप, हृदय रोग, मधुमेह, थायरॉइड, ग्लूकोमा या पेशाब से जुड़ी समस्या है, तो डॉक्टर को बताएं। बच्चों को डॉक्टर की सलाह के बिना यह दवा न दें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें। दवा को ठंडी और सूखी जगह पर रखें।
💊 zumokuf d syrup Uses & Benefits
[{"condition":"Allergic rhinitis","description":"This medicine helps relieve sneezing, runny nose, itchy and watery eyes, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Common cold","description":"This medicine provides temporary relief of nasal congestion, sneezing, and runny nose caused by the common cold.","evidence":"Well-established"},{"condition":"Upper respiratory allergy","description":"This medicine is used for symptomatic relief of upper respiratory allergic symptoms such as postnasal drip and itchy throat.","evidence":"Well-established"},{"condition":"Vasomotor rhinitis","description":"This medicine may help reduce nasal stuffiness and sneezing in non-allergic rhinitis, though evidence is more limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Sinusitis-related congestion","description":"Sometimes used off-label to relieve congestion associated with sinusitis, but it does not treat the underlying infection.","evidence":"Limited"},{"condition":"Eustachian tube dysfunction","description":"Occasionally used off-label to reduce nasal mucosal swelling and improve ear pressure symptoms, but evidence is not strong.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis and common cold
Also treats: Upper respiratory allergy, Vasomotor rhinitis, Sinus congestion
📋 Drug Information
| Generic Name(s) | Phenylephrine (12.5mg) + Chlorpheniramine Maleate (2mg) |
| Brand Name | zumokuf d syrup |
| Manufacturer | Mathis Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep the bottle tightly closed when not in use. |
| Shelf Life | Not established from the available information. Refer to the expiry date printed on the package. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. This medicine is a symptomatic treatment and is not specifically covered by WHO guidelines for allergic rhinitis or common cold. |
| ICMR Guideline | Not established from the available information. ICMR guidelines may recommend symptomatic treatment for allergic rhinitis and common cold, but specific recommendations for this fixed-dose combination are not established. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Phenylephrine is a selective alpha-1 adrenergic receptor agonist that causes vasoconstriction of nasal blood vessels, reducing swelling and congestion in the nasal passages. Chlorpheniramine maleate is a first-generation histamine H1 receptor antagonist that blocks histamine at H1 receptors, reducing sneezing, itching, runny nose, and watery eyes. Together, they provide decongestant and antihistamine effects for upper respiratory allergy and cold symptoms.
Mechanism Steps
💡 How to Take zumokuf d syrup
Strength: Syrup containing phenylephrine 12.5 mg and chlorpheniramine maleate 2 mg per dose (as per the product composition).
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and renal and hepatic function. A common adult dose for immediate-release oral syrup containing phenylephrine 12.5 mg and chlorpheniramine maleate 2 mg per dose is one dose every 4 to 6 hours as needed, not to exceed the maximum daily dose recommended on the label or by the doctor. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine should not be used in newborns or premature infants. For older children, dosing depends on age and weight and must be determined by a qualified clinician. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially drowsiness, confusion, dry mouth, and urinary retention. Use with caution and at the lowest effective dose. Dose must be individualized by a qualified clinician based on renal and hepatic function and other medical conditions. |
| Renal Impairment | Not established from the available information. Use with caution in patients with severe kidney disease. Dose adjustment may be needed and must be determined by a qualified clinician. |
| Hepatic Impairment | Not established from the available information. Use with caution in patients with severe liver disease. Dose adjustment may be needed and must be determined by a qualified clinician. |
| Maximum Daily Dose | Not established from the available information for this specific syrup formulation. Do not exceed the maximum daily dose recommended by your doctor or the product label. For adults, the maximum daily dose of phenylephrine in over-the-counter products is generally limited, and chlorpheniramine should not exceed the recommended daily amount. Always follow the prescribed or label instructions. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zumokuf d syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Other decongestants | Major | |
| Tricyclic antidepressants | Major | |
| CNS depressants | Major | |
| Beta-blockers | Moderate | |
| Anticholinergics | Moderate | |
| Digoxin | Moderate | |
| Warfarin | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other sympathomimetic decongestants
- Tricyclic antidepressants
- Central nervous system depressants (alcohol, opioids, benzodiazepines, sleep aids)
⚡ Moderate Interactions
- Beta-blockers
- Anticholinergic drugs (e.g., oxybutynin, benztropine, some antipsychotics)
- Digoxin
- Oral anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impaired coordination caused by chlorpheniramine. Combining alcohol with this medicine can also increase the risk of falls and accidents. If you drink alcohol regularly, discuss this with your doctor before using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to phenylephrine, chlorpheniramine maleate, or any other ingredient in this medicine.","Use in newborns and premature infants.","Severe hypertension or severe coronary artery disease.","Narrow-angle glaucoma.","Urinary retention or severe benign prostatic hyperplasia.","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI.","Severe liver or kidney disease, unless directed by a doctor."]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.","Do not drink alcohol while taking this medicine.","Use with caution in patients with high blood pressure, heart disease, diabetes, thyroid disorders, or glaucoma.","Do not use for more than a few days without consulting a doctor, especially in children.","Keep out of reach of children. Overdose in children can be dangerous.","Do not use this medicine to treat a bacterial infection; it does not replace antibiotics.","Consult a doctor before use if you are pregnant, planning pregnancy, or breastfeeding.","Elderly patients may be more sensitive to the side effects, especially drowsiness and confusion."]
🤱 Lactation Safety
Not established from the available information. Chlorpheniramine may pass into breast milk and cause drowsiness in a nursing infant. Phenylephrine may reduce breast milk production. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, hallucinations, seizures, fast or irregular heartbeat, high blood pressure, and difficulty breathing. If you suspect an overdose, seek emergency medical attention immediately. Do not try to induce vomiting unless instructed by a healthcare professional. Treatment is supportive and may include monitoring of vital signs, administration of activated charcoal if appropriate, and management of specific symptoms such as seizures or arrhythmias. Always bring the medicine container to the hospital.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as directed by your doctor or as written on the label. Do not increase the dose or take it more often than recommended. Avoid alcohol and other sedating medicines such as sleeping pills, anxiety medicines, or opioid pain relievers because they can add to the drowsiness caused by this medicine. If you have high blood pressure, heart disease, diabetes, thyroid problems, glaucoma, or an enlarged prostate, tell your doctor before using this medicine. Do not use this medicine for more than a few days without medical advice, especially in children. Keep this medicine out of the reach of children and store it at room temperature, away from direct sunlight and moisture. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to the side effects of this medicine, especially drowsiness, confusion, dry mouth, constipation, and urinary retention. The risk of falls and fractures may increase. Use the lowest effective dose for the shortest duration necessary. Consult a doctor before use, especially if you have heart disease, hypertension, glaucoma, or prostate enlargement.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before using this medicine. Phenylephrine and chlorpheniramine should be used during pregnancy only if clearly needed and under medical supervision. Discuss alternative treatments that may be safer for you and your baby.
🏥 Post-Surgery Considerations
Not established from the available information. If you have recently had surgery, consult your doctor before using this medicine, especially if you are taking other medications or have underlying health conditions. Phenylephrine can affect blood pressure and heart rate, which may be important after certain surgeries.
🦷 Dental Procedures
Not established from the available information. Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with other medications used during dental procedures. If you are scheduled for dental surgery, discuss with your doctor whether to continue this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness, which can affect your coordination. Avoid strenuous exercise or activities that require alertness until you know how this medicine affects you. If you exercise outdoors, be aware of allergens such as pollen, which may worsen your symptoms.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks that require concentration. It is best to avoid these activities until you know how the medicine affects you. If your job requires alertness, discuss with your doctor about timing your doses or alternative treatments. Dry mouth and dizziness may also be bothersome at work; keep water handy and rise slowly from sitting positions.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within a few days, if they worsen, or if you experience any serious side effects such as fast heartbeat, difficulty urinating, severe drowsiness, or allergic reactions. Do not stop prescribed medicines without talking to your doctor first.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of decongestants like phenylephrine can lead to rebound congestion, and long-term antihistamine use may cause persistent drowsiness, dry mouth, and urinary retention. If you need this medicine for more than a few days, consult your doctor to determine the underlying cause and appropriate treatment. Regular monitoring of blood pressure and heart rate may be needed in patients with cardiovascular conditions.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Using saline sprays or rinses can help relieve nasal congestion without medication.
Evidence: Well-establishedReducing exposure to allergens such as dust, pollen, and pet dander can decrease allergy symptoms.
Evidence: Well-establishedThese are effective for allergic rhinitis and may be recommended by your doctor as an alternative or add-on treatment.
Evidence: Well-establishedNon-sedating antihistamines may be an alternative if drowsiness is a concern.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. This medicine does not interact with vaccines, but if you are acutely ill with fever, vaccination may be postponed until you recover. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate or freeze unless specified.
✅ DO
Keep the bottle tightly closed and in the original container.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it in a cool, dry place away from direct sunlight and moisture. If crossing time zones, continue your regular dosing schedule as advised by your doctor; do not double doses. Check customs regulations for carrying medicines in your destination country. If you are flying, keep the medicine in your carry-on luggage to avoid temperature extremes in checked baggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving symptoms within 30 to 60 minutes after taking a dose, but this can vary from person to person.
A: This medicine is intended for short-term use. Do not use it for more than a few days without consulting your doctor, especially if symptoms persist or worsen.
A: You should avoid taking other cold medicines that contain similar ingredients (decongestants or antihistamines) because it can lead to overdose. Always check with your doctor or pharmacist.
A: This medicine should not be used in newborns or premature infants. For older children, dosing must be determined by a pediatrician based on age and weight.
A: This medicine may cause drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
A: No, alcohol should be avoided because it increases drowsiness and sedation.
🤔 Common Patient Concerns
🔄 Substitutes for zumokuf d syrup
View AllAlternative brands with exact same active ingredient:
-
chericof capsuleSun Pharmaceutical Industries Ltd ₹35.00 23% CHEAPER
-
cindexa syrupCinerea Biotech Pvt Ltd ₹41.00 9.8% CHEAPER
-
xonus-d syrupCronus Biotech Ltd ₹42.09 7.4% CHEAPER
-
histodar syrupAnze Biotech ₹42.19 7.2% CHEAPER
-
corun-d syrupVentus Pharmaceuticals Pvt Ltd ₹50.63 11.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure a cold or allergy permanently.
Fact: This medicine only relieves symptoms; it does not cure the underlying cold or allergy. - Myth: It is safe to take this medicine with any other cold medicine.
Fact: Many cold medicines contain similar ingredients, and combining them can lead to overdose and serious side effects. - Myth: This medicine is safe for newborns and infants.
Fact: This medicine should not be used in newborns or premature infants and should be used in older children only under a doctor's supervision. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol increases drowsiness and sedation and should be avoided.
🔄 Alternative Options
Generic Alternatives
- Phenylephrine + Chlorpheniramine Maleate syrup (generic)
Brand Alternatives
- Histodar syrup