Fytobact 250 mg/250 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe rash, blistering, or peeling skin
- Severe or bloody diarrhoea
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
- Yellowing of the skin or eyes
- High fever with chills
If experiencing severe symptoms, call emergency services immediately.
What is zostum 250 mg/250 mg injection used for?
This medicine is a combination antibiotic injection containing cefoperazone and sulbactam. It is used to treat serious bacterial infections. It works by killing bacteria and is given by a healthcare professional.
- Generic Name: Cefoperazone (250mg) + Sulbactam (250mg)
- Manufacturer: Zuventus Healthcare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zostum 250 mg/250 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफोपेराज़ोन और सल्बैक्टम का संयोजन है, जिसे इंजेक्शन के रूप में दिया जाता है। यह गंभीर बैक्टीरियल संक्रमणों जैसे निमोनिया, मूत्र मार्ग संक्रमण, पेट के अंदर के संक्रमण, त्वचा संक्रमण और रक्त संक्रमण के इलाज के लिए उपयोग की जाती है। यह दवा बैक्टीरिया को मारकर काम करती है और इसे डॉक्टर या नर्स द्वारा ही दिया जाना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द, चकत्ते, खुजली और इंजेक्शन लगाने की जगह पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज एलर्जी, त्वचा पर गंभीर प्रतिक्रिया, और आंतों का गंभीर संक्रमण शामिल हो सकता है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपनी सभी एलर्जी और किडनी या लीवर की समस्याओं के बारे में डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। इलाज के दौरान शराब न पिएं। कोई भी नया लक्षण जैसे गंभीर दस्त, चकत्ते या सांस लेने में कठिनाई होने पर तुरंत डॉक्टर को सूचित करें।
💊 zostum 250 mg/250 mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat moderate to severe bacterial pneumonia caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against many gram-negative bacteria causing pyelonephritis and complicated UTIs.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for peritonitis, abscesses, and biliary tract infections.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, wound infections, and abscesses caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bloodstream infections (septicemia)","description":"Used for bacteremia caused by susceptible gram-negative and gram-positive organisms.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and endometritis when caused by susceptible bacteria.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as empirical therapy in cancer patients with fever and low white blood cell counts, though not specifically approved for this indication.","evidence":"Limited"},{"condition":"Surgical prophylaxis","description":"Occasionally used before certain surgeries to prevent infection, but not a standard first-line choice.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms.
Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin infections, Septicemia
📋 Drug Information
| Generic Name(s) | Cefoperazone (250mg) + Sulbactam (250mg) |
| Brand Name | zostum 250 mg/250 mg injection |
| Manufacturer | Zuventus Healthcare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the dry powder at room temperature (15-30°C) in a dry place, protected from light. After reconstitution, the solution should be used immediately or stored as directed by the pharmacist. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Cefoperazone is a third-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial death. Sulbactam is a beta-lactamase inhibitor that protects cefoperazone from destruction by certain beta-lactamase enzymes produced by bacteria. Together, they extend the antibiotic's spectrum to cover many beta-lactamase-producing organisms.
Mechanism Steps
💡 How to Take zostum 250 mg/250 mg injection
Strength: Each vial contains cefoperazone sodium equivalent to 250 mg cefoperazone and sulbactam sodium equivalent to 250 mg sulbactam.
Dosage Information
| Adult Dosage | The usual adult dose ranges from 1 to 2 grams of cefoperazone combined with 1 to 2 grams of sulbactam every 12 hours, depending on the severity and type of infection. For severe infections, the dose may be increased to 4 grams of cefoperazone with 4 grams of sulbactam per day divided every 12 hours. The maximum recommended daily dose is 8 grams of cefoperazone with 8 grams of sulbactam. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can increase the risk of side effects. Dose adjustment may be necessary based on kidney function. Use with caution and monitor renal function. |
| Renal Impairment | In patients with renal impairment (creatinine clearance less than 30 mL/min), dose adjustment may be required. For cefoperazone, no adjustment is needed for mild to moderate renal impairment, but for sulbactam, dose reduction is recommended. Consult a doctor for specific dosing. |
| Hepatic Impairment | In patients with hepatic impairment, cefoperazone elimination may be prolonged. Dose adjustment may be necessary. Monitor liver function closely. |
| Maximum Daily Dose | The maximum recommended daily dose is 8 grams of cefoperazone with 8 grams of sulbactam, divided into two doses. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zostum 250 mg/250 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Gentamicin | Major | |
| Furosemide | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Methotrexate | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor | |
| Alcohol | Moderate | |
| Other antibiotics | Variable |
🚨 Major Interactions
- Warfarin
- Aminoglycosides (e.g., gentamicin, amikacin)
- Loop diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
- Methotrexate
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol may worsen side effects such as nausea, vomiting, and may increase the risk of a disulfiram-like reaction (flushing, headache, palpitations).
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to cefoperazone, sulbactam, or any other cephalosporin or beta-lactam antibiotic.","Previous history of severe immediate hypersensitivity reaction to penicillins or cephalosporins.","Use in patients with a history of anaphylaxis to beta-lactam antibiotics."]
⚠️ Warnings & Precautions
["Before starting therapy, ask about previous allergic reactions to antibiotics.","Use with caution in patients with kidney or liver impairment; dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May cause false-positive results in urine glucose tests using copper reduction methods.","Avoid alcohol during treatment due to risk of disulfiram-like reaction.","Ensure adequate hydration during treatment.","Monitor for signs of bleeding, especially in patients on anticoagulants."]
🤱 Lactation Safety
Cefoperazone and sulbactam are excreted in small amounts in breast milk. Consult your doctor before breastfeeding while on this medicine. The benefits should be weighed against potential risks to the infant.
💊 Overdose Management
Overdose with this medicine is unlikely due to its parenteral administration by healthcare professionals. In case of accidental overdose, treatment should be symptomatic and supportive. Cefoperazone and sulbactam can be removed by hemodialysis, which may be considered in severe cases. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
Since this medicine is given by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible to reschedule. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a setting where emergency treatment for allergic reactions is available. Before receiving this medicine, tell your doctor about all your allergies, especially to antibiotics, and about any kidney or liver problems. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Do not attempt to self-administer this injection. Complete the full course as prescribed, even if you feel better, to prevent resistance. Avoid alcohol during treatment as it may worsen side effects. Report any new symptoms such as severe diarrhoea, rash, or difficulty breathing immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. Dose adjustment may be needed. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It should only be used if clearly needed. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent or treat infections. Follow your surgeon's instructions carefully. Report any signs of infection like fever, redness, or discharge.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may interact with other medications used during dental procedures. Your dentist may need to coordinate with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from a serious infection. Light activity like walking is fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to take time off work or school while receiving this medicine, especially if you are hospitalized. It may cause dizziness or fatigue, so avoid driving or operating heavy machinery until you know how it affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. Stopping early can lead to treatment failure and antibiotic resistance. Your doctor will decide when to stop based on your clinical response and test results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and changes in kidney or liver function. It is generally used for short courses. Prolonged use should be monitored with regular blood tests. If you need long-term therapy, your doctor will assess the risks and benefits.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the bacteria and its sensitivity, other antibiotics like ceftriaxone, piperacillin-tazobactam, or carbapenems may be used.
Evidence: Well-establishedRest, hydration, and fever control are important alongside antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are due for any vaccines, inform your doctor. Live vaccines should be avoided during acute infection.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Use reconstituted solution immediately
❌ DON'T
Do not store reconstituted solution for long periods
✈️ Traveling with This Medicine
This medicine is given in a healthcare setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. If you need treatment while traveling, inform the local doctor about your recent antibiotic use.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after administration, but you may not feel better for 1-2 days. Complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a clinical setting due to the risk of serious allergic reactions.
A: Report any side effects to your doctor immediately. Mild side effects like nausea may resolve, but severe symptoms like difficulty breathing require emergency care.
🤔 Common Patient Concerns
🔄 Substitutes for zostum 250 mg/250 mg injection
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Frigen 250mg/250mg InjectionSanjivani Parenteral Ltd ₹75.00 32.4% CHEAPER
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ceftinez cs 250mg/250mg injectionSitnez Biocare Pvt Ltd ₹79.69 28.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses. - Myth: You can stop the injection once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine must only be given by a healthcare professional in a clinical setting due to the risk of serious allergic reactions.
🔄 Alternative Options
Generic Alternatives
- Cefoperazone and sulbactam injection (generic versions available)
Brand Alternatives
- Fytobact 250 mg/250 mg injection