Nupime-T Injection: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Seizures or confusion
- Decreased urine output or swelling in legs
- Severe skin rash with blistering or peeling
- Persistent high fever despite treatment
If experiencing severe symptoms, call emergency services immediately.
What is zopime t 1gm/125mg injection used for?
This medicine is a combination antibiotic injection containing cefepime and tazobactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and is given by a healthcare professional.
- Generic Name: Cefepime (1gm) + Tazobactum (125mg)
- Manufacturer: Mexato Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zopime t 1gm/125mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफेपाइम और टैज़ोबैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में डॉक्टर द्वारा इंजेक्शन के रूप में दी जाती है। यह मूत्र मार्ग, पेट, त्वचा और फेफड़ों के संक्रमण में प्रभावी है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए नहीं है।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, दाने और इंजेक्शन की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, गंभीर दस्त, दौरे और गुर्दे की समस्या हो सकती है। किसी भी असामान्य लक्षण की सूचना तुरंत डॉक्टर को दें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या स्वास्थ्यकर्मी द्वारा दी जानी चाहिए। अपनी सभी एलर्जी और दवाओं के बारे में डॉक्टर को बताएं। गुर्दे या यकृत की बीमारी हो तो डॉक्टर को सूचित करें। इलाज के दौरान शराब न पिएं। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें।
💊 zopime t 1gm/125mg injection Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"Used to treat serious kidney and bladder infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Effective against infections in the abdominal cavity, often in combination with surgical drainage.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe skin infections including cellulitis and abscesses.","evidence":"Well-established"},{"condition":"Pneumonia","description":"Used for moderate to severe community-acquired or hospital-acquired pneumonia.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for fever in patients with low white blood cell counts.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used off-label for bacterial meningitis when other options are unsuitable.","evidence":"Limited"},{"condition":"Bone and joint infections","description":"May be used off-label for osteomyelitis or septic arthritis based on culture results.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Complicated urinary tract infections, Intra-abdominal infections, Skin and soft tissue infections, Pneumonia, Febrile neutropenia
📋 Drug Information
| Generic Name(s) | Cefepime (1gm) + Tazobactum (125mg) |
| Brand Name | zopime t 1gm/125mg injection |
| Manufacturer | Mexato Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular) |
| Storage | Store the unreconstituted vial at room temperature (20-25°C). After reconstitution, the solution should be used immediately or stored as directed by the pharmacist. Protect from light and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefepime, the active cephalosporin component, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death. Tazobactam is a beta-lactamase inhibitor that protects cefepime from degradation by certain beta-lactamase enzymes produced by resistant bacteria. This combination extends the spectrum of activity against organisms that would otherwise be resistant to cefepime alone.
Mechanism Steps
💡 How to Take zopime t 1gm/125mg injection
Strength: Injection: Cefepime 1 g + Tazobactam 125 mg per vial.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1-2 grams of cefepime every 8-12 hours, depending on the severity and type of infection. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. For severe infections, higher doses may be used. Treatment duration varies from 7 to 14 days or longer as clinically indicated. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may have reduced renal function and require dose adjustment. Monitor renal function closely and individualize dosing. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. For creatinine clearance 30-60 mL/min, the usual dose is 1-2 g every 12 hours; for 11-29 mL/min, 1-2 g every 24 hours; for <10 mL/min, 1 g every 24 hours. Doses should be administered after dialysis on dialysis days. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment alone. However, caution is advised in patients with combined hepatic and renal impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 grams of cefepime (as 2 grams every 8 hours) for adults with normal renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zopime t 1gm/125mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Warfarin | Major | |
| Furosemide | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Warfarin
- Loop diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine as it may worsen side effects such as nausea, dizziness, and stomach upset.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to cefepime, tazobactam, or other beta-lactam antibiotics.","Previous anaphylactic reaction to penicillins or cephalosporins."]
⚠️ Warnings & Precautions
["Serious hypersensitivity reactions, including anaphylaxis, have been reported.","Clostridioides difficile-associated diarrhea may occur; monitor for severe diarrhea.","Seizures have been reported, especially in patients with renal impairment.","Dose adjustment is required in patients with renal impairment.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Use with caution in patients with a history of seizures or CNS disorders."]
🤱 Lactation Safety
Cefepime is excreted in human milk in low amounts. Tazobactam is also excreted. Caution is advised; consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, and seizures. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove cefepime from the blood in severe cases. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, contact your healthcare provider for guidance. Do not attempt to self-administer.
Additional Safety Advice
This medicine should only be given by a healthcare professional in a clinical setting. Inform your doctor about any allergies to antibiotics, especially penicillins or cephalosporins. Tell your doctor if you have kidney disease, liver disease, or a history of seizures. Do not breastfeed while receiving this medicine without consulting your doctor. Avoid alcohol during treatment as it may worsen side effects. Complete the full course as prescribed, even if you feel better, to prevent resistance.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require dose adjustment. They are also at higher risk of seizures and should be monitored closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is generally considered safe in pregnancy when clearly needed, but the benefits and risks should be discussed.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent or treat infections. It is important to monitor for signs of infection and complete the prescribed course.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures. No specific precautions are required, but good oral hygiene is important.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work. You may experience fatigue or dizziness; avoid driving or operating machinery until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and superinfections. Prolonged therapy requires monitoring of kidney and liver function. It is important to use this medicine only when prescribed and for the recommended duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used after initial improvement with injectable therapy.
Evidence: Well-establishedNecessary for abscesses or infected collections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. However, inform your doctor about your vaccination status, especially for pneumococcal and influenza vaccines, as they can prevent certain infections.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. Inform your doctor if you plan to travel to areas with high risk of infections.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a clinical setting.
A: Report any side effects to your doctor immediately. Do not self-treat.
🤔 Common Patient Concerns
🔄 Substitutes for zopime t 1gm/125mg injection
View AllAlternative brands with exact same active ingredient:
-
quadrocef 1gm/125mg injectionNeiss Labs Pvt Ltd ₹345.00 2.2% COSTLIER
-
nupime-t injectionPinenut Life Care India Pvt Ltd ₹364.69 8.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine must be given by a healthcare professional in a clinical setting. It is not for self-administration.
🔄 Alternative Options
Generic Alternatives
- Cefepime + Tazobactam injection (generic versions may be available)
Brand Alternatives
- Nupime-T Injection