Axobact 1gm/500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Rash with blistering or peeling skin
- Unusual bleeding or bruising
- Decreased urine output or swelling
- Yellowing of skin or eyes
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is axobact 1gm/500mg injection used for?
This medicine is a combination antibiotic given intravenously to treat serious bacterial infections. It contains cefoperazone, a cephalosporin, and sulbactam, which helps overcome bacterial resistance. It is used in hospitals for infections of the lungs, urine, skin, abdomen, and blood.
- Generic Name: Cefoperazone + Sulbactam
- Manufacturer: Mexato Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 axobact 1gm/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयुक्त एंटीबायोटिक है जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। इसमें सेफोपेराजोन और सल्बैक्टम होते हैं। यह फेफड़ों, मूत्र मार्ग, त्वचा, पेट और रक्त के संक्रमण में प्रभावी है। यह केवल अस्पताल में डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है। वायरल संक्रमण जैसे सर्दी-जुकाम में यह काम नहीं करती।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, पेट दर्द, त्वचा पर चकत्ते और इंजेक्शन की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त, रक्त विकार और किडनी की समस्या हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्यकर्मी द्वारा अस्पताल में दी जानी चाहिए। अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से, डॉक्टर को बताएं। किडनी या लीवर की बीमारी हो तो जानकारी दें। उपचार के दौरान शराब न पिएं। दवा का पूरा कोर्स पूरा करें। कोई भी नया लक्षण जैसे सांस लेने में कठिनाई, चकत्ते या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
💊 axobact 1gm/500mg injection Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used for community-acquired and hospital-acquired pneumonia caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated urinary tract infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, and wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in peritonitis, cholecystitis, and other abdominal infections often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Septicemia","description":"Used for bloodstream infections caused by susceptible Gram-negative and Gram-positive bacteria.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Treats pelvic inflammatory disease and endometritis caused by susceptible organisms.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Febrile neutropenia","description":"Sometimes used as empirical therapy in cancer patients with fever and low white blood cell counts.","evidence":"Limited"},{"condition":"Meningitis","description":"May be used off-label for bacterial meningitis when other options are not suitable, but not first-line.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Skin infections, Intra-abdominal infections, Septicemia
📋 Drug Information
| Generic Name(s) | Cefoperazone + Sulbactam |
| Brand Name | Acuzone S 1000mg/500mg Injection |
| Manufacturer | Mexato Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) infusion or injection |
| Storage | Store the dry powder at room temperature (15-30°C) in a dry place, protected from light. After reconstitution, the solution should be used within the time specified by the manufacturer, typically within 24 hours if refrigerated. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise stated on the label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial death. Sulbactam irreversibly inhibits certain beta-lactamase enzymes, protecting cefoperazone from degradation and extending its spectrum against beta-lactamase-producing bacteria.
Mechanism Steps
💡 How to Take axobact 1gm/500mg injection
Strength: 1 gram cefoperazone + 500 milligrams sulbactam per vial for intravenous injection.
Dosage Information
| Adult Dosage | The usual adult dose ranges from 1 to 2 grams of cefoperazone every 12 hours, with sulbactam in a 1:1 or 1:2 ratio depending on the product. For severe infections, up to 4 grams of cefoperazone per day may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and may require lower doses. Dose must be individualized by a qualified clinician based on renal function and clinical response. |
| Renal Impairment | In patients with creatinine clearance less than 30 mL/min, dose adjustment is recommended. Monitor kidney function closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with severe liver disease, dose reduction may be necessary. Monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 4 grams of cefoperazone component, but this may vary based on the product and clinical situation. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of axobact 1gm/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Gentamicin | Major | |
| Furosemide | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- Warfarin
- Aminoglycosides (e.g., gentamicin)
- Alcohol
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Probenecid
🍷 Alcohol Interaction
Avoid alcohol during treatment and for at least 72 hours after the last dose, as it may cause a disulfiram-like reaction with flushing, nausea, vomiting, and headache.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to penicillins, cephalosporins, or sulbactam","Previous anaphylactic reaction to beta-lactam antibiotics","Use in patients with known carnitine deficiency (due to sulbactam component)"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions can occur. Ask about previous beta-lactam allergies before use.","Clostridioides difficile-associated diarrhea may occur; evaluate if diarrhea develops.","Use with caution in patients with kidney or liver impairment; dose adjustment may be needed.","May cause false-positive results in urine glucose tests and direct Coombs test.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Avoid alcohol during treatment due to disulfiram-like reactions."]
🤱 Lactation Safety
Cefoperazone and sulbactam are excreted in breast milk in small amounts. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose may cause nausea, vomiting, diarrhea, and seizures. Treatment is supportive and symptomatic. Hemodialysis may be considered in severe cases, especially with renal impairment. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
Since this medicine is given by a healthcare professional in a hospital or clinic, missed doses are unlikely. If you miss an appointment for your dose, contact your healthcare provider as soon as possible to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional in a setting where emergency care is available. Inform your doctor about all allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems. Do not use this medicine if the vial is damaged or the solution contains particles. Complete the full course as prescribed, even if you feel better, to prevent resistance. Avoid alcohol during treatment. Report any new symptoms such as rash, difficulty breathing, or severe diarrhea without delay.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require lower doses. Monitor kidney function closely and watch for signs of toxicity.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is generally used only if clearly needed during pregnancy.
🏥 Post-Surgery Considerations
This medicine is often used to prevent or treat surgical site infections. It is given intravenously in the hospital setting.
🦷 Dental Procedures
Inform your dentist if you are on this medicine. It may be used prophylactically before certain dental procedures in high-risk patients, but this is determined by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Rest is recommended during acute infection. Gradually resume light activities as you recover. Avoid strenuous exercise until your doctor approves.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may need to stay in the hospital during treatment. Driving and operating machinery are not recommended until you have fully recovered and your doctor approves.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rarely blood or liver abnormalities. It is usually given for a limited duration. Prolonged use requires monitoring of blood counts, liver and kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics like ceftriaxone, piperacillin-tazobactam, or carbapenems may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics do not interact with vaccines. However, if you are scheduled for a vaccine, inform your doctor about your current treatment.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining vials as directed, and declare them at customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours, but you may not feel better for 1-2 days. Complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor immediately. Mild side effects like nausea may resolve, but serious effects need urgent attention.
🤔 Common Patient Concerns
🔄 Substitutes for axobact 1gm/500mg injection
View AllAlternative brands with exact same active ingredient:
-
epojen injectionJenfer Biosciences Pvt Ltd ₹32.81 92.4% CHEAPER
-
cefones s injectionFitwel Pharmaceuticals Private Limited ₹160.00 62.8% CHEAPER
-
zobeta 1gm/500mg injectionStallion Laboratories Pvt Ltd ₹175.00 59.3% CHEAPER
-
magnamax s 1gm/500mg injectionApus Life Pvt Ltd ₹182.81 57.5% CHEAPER
-
sepraz 1.5gm injectionNimbus Health Care Pvt Ltd ₹182.81 57.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is ineffective against viruses. - Myth: You can stop the medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine must be given by a healthcare professional in a medical setting due to the risk of serious allergic reactions and the need for proper administration.
🔄 Alternative Options
Generic Alternatives
- Cefoperazone + Sulbactam injection (generic)
Brand Alternatives
- Not established from the available information.