Encelin M 50/850 Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Rapid breathing or shortness of breath
- Severe muscle pain or weakness
- Persistent vomiting or severe abdominal pain
- Yellowing of skin or eyes
- Dark urine or decreased urine output
- Severe headache with visual changes
- Swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is zomelis met 850mg/50mg tablet used for?
This medicine is a combination of Metformin and Vildagliptin used to treat type 2 diabetes. It helps control blood sugar by improving insulin sensitivity and increasing insulin release after meals. It is taken twice daily with meals.
- Generic Name: Metformin (850mg) + Vildagliptin (50mg)
- Manufacturer: Eris Lifesciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 zomelis met 850mg/50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेटफॉर्मिन और विल्डाग्लिप्टिन का संयोजन है, जिसका उपयोग टाइप 2 डायबिटीज में ब्लड शुगर को नियंत्रित करने के लिए किया जाता है। यह शरीर में इंसुलिन की कार्यक्षमता को बढ़ाती है और भोजन के बाद इंसुलिन के स्तर को बढ़ाने में मदद करती है। इसे भोजन के साथ दिन में दो बार लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, दस्त, पेट में असहजता, सिरदर्द और चक्कर आना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में लैक्टिक एसिडोसिस, पैन्क्रियाटाइटिस और एलर्जी प्रतिक्रियाएं शामिल हैं, जिनके लिए तुरंत डॉक्टर से संपर्क करना चाहिए।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें ताकि पेट की समस्या कम हो। पर्याप्त पानी पिएं। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस का खतरा बढ़ सकता है। बिना डॉक्टर की सलाह के दवा बंद या डोज न बदलें। नियमित रूप से ब्लड शुगर की जांच कराएं।
💊 zomelis met 850mg/50mg tablet Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Improves glycemic control in adults whose blood sugar is not adequately controlled with metformin alone or other oral agents.","evidence":"Well-established"},{"condition":"Prediabetes (off-label)","description":"Sometimes used off-label to delay progression to diabetes in high-risk individuals, but not approved for this use.","evidence":"Limited"}]
Off-label uses: [{"condition":"Polycystic Ovary Syndrome (PCOS)","description":"Metformin component may improve insulin resistance in PCOS, but vildagliptin is not standard for this indication.","evidence":"Limited"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Prediabetes, Polycystic Ovary Syndrome (off-label)
📋 Drug Information
| Generic Name(s) | Metformin (850mg) + Vildagliptin (50mg) |
| Brand Name | zomelis met 850mg/50mg tablet |
| Manufacturer | Eris Lifesciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Metformin decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Vildagliptin inhibits dipeptidyl peptidase-4 (DPP-4), thereby increasing the levels of active incretin hormones (GLP-1 and GIP). This leads to increased insulin secretion from pancreatic beta cells and decreased glucagon secretion from alpha cells, especially after meals.
Mechanism Steps
💡 How to Take zomelis met 850mg/50mg tablet
Strength: Tablet containing Metformin 850 mg and Vildagliptin 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally twice daily with meals. The dose may be adjusted by your doctor based on your blood sugar levels, kidney function, and overall health. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Renal function should be assessed before and during treatment. Dose adjustments may be necessary based on kidney function. |
| Renal Impairment | Assess renal function before starting and at least annually. If eGFR is 30-45 mL/min/1.73 m², use with caution and consider dose reduction. Contraindicated if eGFR < 30 mL/min/1.73 m². |
| Hepatic Impairment | Use with caution in patients with mild to moderate hepatic impairment. Contraindicated in severe hepatic impairment. Monitor liver function tests. |
| Maximum Daily Dose | The maximum recommended daily dose is metformin 2000 mg and vildagliptin 100 mg, but individual dosing must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of zomelis met 850mg/50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Iodinated contrast media | Major | |
| Alcohol | Major | |
| Diuretics | Moderate | |
| Cationic drugs | Moderate | |
| Insulin | Moderate | |
| Sulfonylureas | Moderate | |
| ACE inhibitors | Minor | |
| Thiazide diuretics | Minor |
🚨 Major Interactions
- Iodinated contrast media
- Alcohol
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Cationic drugs (e.g., amiloride, digoxin, morphine)
- Insulin or sulfonylureas
🍷 Alcohol Interaction
Alcohol should be avoided or limited while taking this medicine because it can increase the risk of lactic acidosis and hypoglycemia. Discuss safe limits with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe renal impairment (eGFR < 30 mL/min/1.73 m²)","Acute or chronic metabolic acidosis, including diabetic ketoacidosis","Hypersensitivity to metformin, vildagliptin, or any component","Severe hepatic impairment","Acute conditions that may alter renal function (e.g., dehydration, severe infection, shock)"]
⚠️ Warnings & Precautions
["Lactic acidosis: Rare but serious. Discontinue and seek immediate medical help if suspected.","Renal function: Assess before initiation and periodically. Dose adjustment may be needed.","Hypoglycemia: Risk increases when used with insulin or sulfonylureas. Monitor blood glucose.","Pancreatitis: Has been reported with vildagliptin. Discontinue if suspected.","Hepatic impairment: Use with caution. Monitor liver function.","Vitamin B12 deficiency: Long-term metformin use may reduce B12 levels. Monitor if symptoms occur.","Surgery: Discontinue temporarily before surgery and contrast procedures.","Alcohol: Avoid excessive intake due to risk of lactic acidosis."]
🤱 Lactation Safety
Metformin is present in breast milk in small amounts. Vildagliptin is also excreted in breast milk in animal studies. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Symptoms may include severe hypoglycemia, lactic acidosis, or pancreatitis. Treatment is supportive and symptomatic. Hemodialysis may be considered for metformin removal in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with meals to reduce gastrointestinal upset. Do not skip meals while on this medicine. Stay well hydrated, especially during hot weather or exercise. Avoid excessive alcohol consumption as it increases the risk of lactic acidosis. Inform your doctor before any surgery or imaging test that uses contrast dye. Do not stop or change the dose without consulting your doctor. Monitor your blood sugar regularly as advised. Report any unusual symptoms like persistent stomach pain, dark urine, or difficulty breathing immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and are at higher risk of lactic acidosis. Renal function should be assessed before and during treatment. Dose adjustments may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. Insulin is generally preferred for managing diabetes during pregnancy. This medicine should be used only if clearly needed under medical supervision.
🏥 Post-Surgery Considerations
Discontinue this medicine temporarily before surgery and inform your surgeon. Resume only after your doctor confirms it is safe, usually after renal function is normal.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. Maintain good oral hygiene as diabetes can increase the risk of gum disease.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial for diabetes management, but monitor your blood sugar before and after exercise. Carry a fast-acting carbohydrate source in case of hypoglycemia. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery if you feel dizzy. Otherwise, it should not significantly impact your daily activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects like lactic acidosis, pancreatitis, or severe allergic reactions, seek immediate medical attention and follow your doctor's advice.
📅 Long-Term Use Effects
Long-term use may require periodic monitoring of kidney function, liver function, and vitamin B12 levels. Metformin can cause vitamin B12 deficiency over time. Vildagliptin may rarely cause pancreatitis or liver injury. Regular follow-up with your doctor is essential to monitor efficacy and safety.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are cornerstone therapies for type 2 diabetes and can complement medication.
Evidence: Well-establishedAlternatives include sulfonylureas, SGLT2 inhibitors, or insulin, depending on individual needs.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, maintain routine vaccinations as recommended for diabetic patients, including influenza and pneumococcal vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times as advised by your doctor. Keep enough supply for the entire trip. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within days, but maximum effect may take 1-2 weeks. Regular monitoring is important.
A: It depends on the severity of kidney impairment. Your doctor will assess your renal function and may adjust the dose or choose an alternative.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. Lifestyle changes and medication are needed for long-term control. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Diabetes is a chronic condition. Stopping medication without medical advice can lead to serious complications. - Myth: This medicine causes weight gain.
Fact: Metformin may cause weight loss or weight neutrality, while vildagliptin is weight-neutral. Weight gain is not a typical side effect.
🔄 Alternative Options
Generic Alternatives
- Metformin 850 mg + Vildagliptin 50 mg tablet
Brand Alternatives
- Zomelis Met 50/850 Tablet
- Jalra M 50/850 Tablet
- Galvus Met 50/850 Tablet